Recent progress in the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases

Abstract

Abstract: Small RNA (known as microRNA, miRNA) is single-stranded non-coding RNA (18-25 nucleotides length), it regulates various proteins by targeting the 3'-untranslated region (3-UTR) of various transcripts, thus dysregulation of miRNA affects a wide range of processes such as cell proliferation and differentiation involved in organ remodeling processes. Current studies demonstrated that post-transcriptional effect of miRNA is involved in the development of chronic liver diseases, while hepatic stellate cells (HSCs) play a vital role in the primary formation of ECM and undergo progressive activation to become myofibroblasts (MFB)-like cells. The aim of this paper is to discuss the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases.

Key words: miRNA, chronic liver diseases, hepatic stellate cells

CLC Number:

R966

SONG Li-ying, PENG Xiang-dong, WANG Chun-jiang, GUO Ren, LIU Shi-kun. Recent progress in the role of miRNA in hepatic stellate cells activation and the chronic hepatic diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1422-1428.

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