Amiodarone and losartan on recurrence and atrial structure for chronic atrial fibrillation after RFCA

Abstract

Abstract: AIM: To investigate influence of amiodarone and losartan on atrial structure and fibrillation recurrence of chronic atrial fibrillation after radiofrequency cathater ablation (RFCA).METHODS: A total of 240 chronic atrial fibrillation patients underwent RFCA were recruited from January 2010 to December 2012, these patients were randomly divided into two groups: amiodarone group (A group, 120 cases) and amiodarone combined with losartan group (B group, 120 cases), according to persistent atrial fibrillation or not, A and B group respectively divided into two subgroups:A₁,A₂ and B₂,B₂, then compared the differences of LAD, LAV and recurrence between A and B group, A₁,A₂ and B₁,B₂ subgroup.RESULTS: There were not significant differences of LAD,LAV before RFCA (P>0.05), and LAD, LAV appeared a decreasing trend after RFCA, A and B group,A₁ and B₁ subgroup at each timepoint and A₂ and B₂ subgroup at 6 months existed significant differences (P<0.05). The maintenance rates of sinus rhythm of A group, A₁ and A₂ subgroup were 50.83%, 53.85% and 48.53% respectively, which were significantly lower than 77.50%, 80.00% and 75.71% of B group, B₁ and B₂ subgroup at 18 months (P<0.05), but the maintenance rates of retreatment patients without significant differences (P>0.05).CONCLUSION: The clinical efficacy of amiodarone combined losartan for chronic AF would be better than amiodarone after RFCA, the recurrence rate is lower, this may be related to atrial remodeling and atrial electrical regulation of losartan, but the clinical value in recurrent patients after RFCA needs further study.

Key words: atrial fibrillation, radiofrequency catheter ablation, amiodarone, losartan

CLC Number:

WU Ji-chu, LUO Can-xiang, OU YANG Ze-wei. Amiodarone and losartan on recurrence and atrial structure for chronic atrial fibrillation after RFCA[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 318-322.

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