Effects of triprolidine tydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis

Abstract

Abstract:

AIM: To study the effects of triprolidine hydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis and its influence on the levels of inflammatory factors. METHODS: 106 patients with allergic rhinitis were collected and were randomly divided into control group and observation group (53 cases each). The control group was given compound ephedrine hydrochloride and cromolyn sodium pellicles, while the observation group was administered with extra triprolidine hydrochloride capsules. The curative effect of allergic rhinitis, disappearance time of related symptoms (nasal itching, nasal congestion, sneezing, runny nose and headache), the levels of inflammatory factors (TNF-α, IL-17, IL-4, IL-8 and IL-13) and the adverse actions were observed and compared. RESULTS:The total effective rate of observation group was 92.5%, which was significantly better than that of control group (79.2%). The nasal itching, nasal congestion, sneezing, runny nose and headache disappeared time in observation group were (1.61±0.22) d, (1.83±0.26) d, (4.34±0.54) d, (2.37±0.24) d and (1.51±0.19) d, respectively, which were significantly shorter than those of the control group (P<0.05). Levels of TNF-α, IL-17, IL-4, IL-8 and IL-13 were (0.83±0.22) ng/mL, (43.15±5.21) ng/mL, (35.42±10.65) ng/mL, (113.12±18.53) ng/mL and (5.44±1.05) ng/mL, which were significantly lower than those of the control group (P<0.05). No significant difference was observed in adverse actions between the two groups. CONCLUSION:Triprolidine hydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis can improve the therapeutic effect, which is worthy of further study.

Key words: allergic rhinitis, triprolidine hydrochloride capsules, compound ephedrine hydrochloride and cromolyn sodium pellicles, inflammatory factors

CLC Number:

R765.21

HONG Chaoqun，WU Yaqing，LV Zhenggang，CHENG Kejia. Effects of triprolidine tydrochloride capsules combined with compound ephedrine hydrochloride and cromolyn sodium pellicles on treating allergic rhinitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 160-164.

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