中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (4): 411-413.DOI: 10.11852/zgetbjzz2018-1020

• 荟萃分析 • 上一篇    下一篇

居住环境因素对出生缺陷影响的Meta分析

提鑫婧, 林梦梦, 刘扬, 付岭岭, 王志萍   

  1. 山东大学公共卫生学院,山东 济南 250000
  • 收稿日期:2018-07-30 修回日期:2018-09-06 发布日期:2019-04-20 出版日期:2019-04-20
  • 通讯作者: 王志萍 E-mail:zhipingw@sdu.edu.cn
  • 作者简介:提鑫婧(1995-),女,河北人,硕士研究生在读,主要研究方向为生殖健康、出生缺陷。

Meta analysis of the influence of living environment factors on birth defects

TI Xin-jing, LIN Meng-meng, LIU Yang, FU Ling-ling, WANG Zhi-ping   

  1. School of Public Health,Shandong University,Jinan,Shandong 250000,China
  • Received:2018-07-30 Revised:2018-09-06 Online:2019-04-20 Published:2019-04-20
  • Contact: WANG Zhi-ping,E-mail:zhipingw@sdu.edu.cn

摘要: 目的 探讨居住地附近存在污染源、孕期居室装修、室内饲养宠物这三种居住环境因素与出生缺陷的关系。方法 在线检索知网、万方和维普数据库,系统收集1977年1月1日—2018年7月30日间公开发表的关于中国出生缺陷影响因素的流行病学相关研究,根据严格的纳入排除标准筛选,对纳入的文献进行异质性检验和效应值合并,并对结果进行敏感性分析、发表偏倚检验及校正。结果 最终纳入21篇文献,采用随机效应模型计算居住地附近存在污染源、孕期居室装修、室内饲养宠物因素危险性的合并OR值分别为2.474(1.659~3.688)、2.149(1.807~555)、2.721(2.006~3.693)(校正后)。结论 居住地附近存在污染源、孕期居室装修、室内饲养宠物这三种居住环境因素会增加出生缺陷发生的风险。

关键词: 出生缺陷, 居住环境, Meta分析

Abstract: Objective To explore the relationship between three living environment factors(living near pollution source, prenatal bedroom decoration and indoor pet raising)and birth defects through Meta?analysis. Methods Published researches on birth defects were retrieved by searching CNKI, Wanfang database and VIP online between January 1st,1977 and July 30th, 2018.Studies were screened according to strict inclusion criteria.Heterogeneity test and effect value combination were performed on the included literature.Sensitivity analysis, publication bias test and correction were performed on the results. Results Finally 21 articles were included in this Meta?analysis.The adjusted merger OR values of living near pollution source, bedroom decoration during pregnancy, pets raising indoors were 2.474(1.659-3.688), 2.149(1.807-2.555) and 2.721(2.006-3.693) through random effects model. Conclusion Living near pollution source, prenatal bedroom decoration and pets raising indoors will increase the risk of birth defects.

Key words: birth defects, living condition, Meta-analysis

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