Abstract: Objective To study the effect of vitamin D supplementation in early preterm infants on the immune function. Methords The 158 preterm infants from Cangzhou People's Hospital were selected in the study,and were divided into the large for gestational age group and small for gestational age group.Each group was randomly divided into control group and experimental group.The control group was given formula feeding.The experimental group on the basis of the control group,was fed vitamin D intake 400 U/d from 3rd to 10th day after birth.Serum 25-(OH) D,IL-2 and IgG,IgA,IgM were tested before and after the experiment,and vitamin D toxicity was observed. Results It was high prevalence of moderately severe vitamin D deficiency in preterm infants.Serum 25-(OH) D level of experimental group was significantly higher than that of the control group(P＜0.05).In the small and large for gestational age group,vitamin D supplementation of 400 U/d respectively increased mean 25-(OH)D levels from 23.556 nmol/L,27.771 nmol/L at birth to 27.423 nmol/L,32.198 nmol/L at discharge.With the development of 25-(OH) D level,IL-2 level increased significantly,experimental group had significant difference compared with the control (P<0.05),while IgG,IgA,IgM had no significant change (P>0.05). Conclusions Early vitamin D supplementation can improve immunity of premature infants.Further research is required on the effect on humoral immunity.

Key words: preterm infants, vitamin D, supplement, early neonatal, immunologic function

摘要： 目的 了解早产儿早期补充维生素D对其免疫功能的影响。方法 选取沧州市人民医院新生儿科早产儿158例,分为大胎龄组和小胎龄组,每组又随机分为对照组和实验组,对照组给予配方奶喂养,实验组给予配方奶+维生素D,于生后第3天开始补充维生素D 400 U/d,服用7 d,实验前后测定血清25-(OH)D、IL-2和IgG、IgA、IgM水平,观察临床有无并发症。结果 早产儿普遍存在维生素D缺乏。给予维生素D治疗后,小胎龄组和大胎龄组血清25-(OH)D均值分别从23.556、27.771 nmol/L提高到27.423、32.198 nmol/L,差异有统计学意义(P<0.05)。 随着25-(OH)D水平的提高,IL-2水平明显提高,实验组与对照组比较差异有统计学意义(P<0.05),而IgG、IgA、IgM水平无明显变化(P>0.05)。结论 提早补充维生素D可以提高早产儿免疫力,对体液免疫的影响需进一步研究。

关键词: 早产儿, 维生素D, 补充, 新生儿早期, 免疫功能