Abstract: Objective To explore the relationship between serum levels of 25-hydroxyvitamin D,calcium,phosphorus of 813 children aged 0~6 years and their age in Zhoushan archipelago area. Methods A total of 813 children aged 0~6 years in 2011 were selected.Their serum levels of 25-hydroxyvitamin D,calcium and phosphorus were detected by electrochemistry method,lon-selective electrode method and phosphomolybdic acid uv spectrophotometry method respectively. Results The difference of serum levels of 25-hydroxyvitamin D between male(87.37±38.42) nmol/L and female(89.00±50.58) nmol/L was not significant (t=-0.518,P＞0.05);The difference of serum levels of calcium between male (2.39±0.12)mmol/L and female (2.37±0.09)mmol/L was significant (t=-2.68,P＜0.01);The difference of serum levels of phosphorus between male (1.74±0.08)mmol/L and female (1.77±0.13) mmol/L was significant (t=-3.97,P＜0.01).Both in male and female,the serum levels of 25-hydroxyvitamin D,calcium and phosphorus decreased with age. Conclusions The serum levels of 25-hydroxyvitamin D,calcium and phosphorus show downward trends with age.Given monitor of vitamin D supplements and calcium,phosphorus are important for children aged 2~6 years.

Key words: 25-hydroxyvitamin D, calcium, phosphorus, children aged 0~6 years, electrochemistry method

摘要： 目的 调查分析舟山海岛地区儿童血清25-羟维生素D、钙和磷水平与年龄变化的关系。方法 选取2011年舟山市妇幼保健院儿保科体检的0～6岁儿童813例,取清晨空腹血,分别用电化学发光法、离子电极法、磷钼酸紫外法检测其血清25-羟维生素D、血清钙、血清磷水平。结果 男童和女童血清25-羟维生素D水平分别为(87.37±38.42) nmol/L和(89.00±50.58)nmol/L,差异无统计学意义(t=-0.518,P＞0.05);男童和女童血清钙水平分别为(2.39±0.12) mmol/L和(2.37±0.09) mmol/L,差异具有高度统计学意义(t=-2.68,P＜0.01);男童和女童血清磷水平分别为(1.74±0.08)mmol/L和(1.77±0.13) mmol/L,差异具有高度统计学意义(t=-3.97,P＜0.01)。男童和女童中血清25-羟维生素D、钙、磷水平都随着年龄增高而呈下降趋势。结论 血清25-羟维生素D、钙、磷水平随着年龄呈下降趋势,对2～6岁的儿童需重视维生素D的补充,并监测其血清钙磷水平。

关键词: 25-羟维生素D, 钙, 磷, 0～6岁儿童, 电化学发光法