Abstract: Objective To evaluate the associations of secreted frizzled-related protein 5(SFRP5),a novel anti-inflammatory adipokine with childhood metabolic syndrome (MS) and the effects of lifestyle interventions on circulating SFRP5 levels in children. Methods A study was conducted among 111 obese children and 49 lean controls,and the height,weight,waist circumference and blood pressure were measured.The blood lipid,blood glucose,and biochemical test were also tested.Venous blood was reserved to detect serum insulin,SFRP5,Wnt5a,hsCRP,leptin and adiponectin.A lifestyle intervention was performed in a subgroup of 31 obese children for 6 months.Indexes were measured at baseline and after lifestyle intervention. Results SFRP5 was significantly lower in obese children with MS compared with other two groups (P<0.05).SFRP5 was negatively correlated with homeostasis model assessment of insulin resistance (HOMA-IR) and leptin/adipo reception (LAR),and was positively correlated with adiponectin after control age and body mass index (BMI) (P<0.05).Furthermore,changes in BMI,blood pressure,HOMA-IR,triglyceride (TG),leptin,LAR were significantly increased,and SFRP5 and adiponectin were decreased after weigh loss intervention among 31children (P<0.05). Conclusions Serum SFRP5 is related with body lipid especially central obesity,lipid disorder,hypertension and hyperinsulinemia.It may be a beneficial adiposity factor which could improve the disorder of body.   

Key words: obesity, secreted frizzled-related protein 5, metabolic syndrome, adipokine, children

摘要： 目的 血清分泌型卷曲相关蛋白5(SFRP5)是新发现的抗炎型脂肪因子,本研究旨在探索SFRP5与儿童代谢综合征(MS)的相关性,并研究经过综合减重干预后SFRP5的变化。方法 将111名肥胖儿童随机分为肥胖伴MS组(n=50)、不伴MS组(n=61),正常体重儿童49名作为对照组,对每位儿童进行身高、体重、腰围、血压等测量,并行血脂、血糖、肝肾功等化验,留取静脉血清标本测血清胰岛素、SFRP5、Wnt5a、hsCRP(超敏C反应蛋白)、瘦素、脂联素水平等。对31名MS儿童进行综合减重方案干预6个月,并分析其减重前后各指标变化。结果 SFRP5在肥胖伴MS患儿中水平较另两组水平低(P<0.05)。矫正年龄及BMI-SDS后,SFRP5与瘦素/脂联素(LAR)、胰岛素抵抗指数(Ln HOMA-IR)仍为负相关(r'=-0.250,r'=-0.284,P均<0.05),与脂联素呈正相关(r'=0.339,P<0.05)。31名经综合减重干预后患儿的BMI、血压、HOMA-IR、甘油三酯、瘦素、LAR较前均降低,脂联素、SFRP5较前升高(P<0.05)。结论 血清SFRP5水平与中心性肥胖、脂质代谢紊乱、高血压、高胰岛素血症密切相关,在儿童MS的发病中有保护作用。

关键词: 肥胖, 血清分泌型卷曲相关蛋白5, 代谢综合征, 脂肪因子, 儿童