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    10 July 2016, Volume 24 Issue 7
    Relationship of serum secreted frizzled-related protein 5 and childhood metabolic syndrome.
    LI Hong-gang,ZHANG Mei-zhen,TAN Xin-rui,XIAO Yan-feng.
    2016, 24(7):  678-681.  DOI: 10.11852/zgetbjzz2016-24-07-03
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    Objective To evaluate the associations of secreted frizzled-related protein 5(SFRP5),a novel anti-inflammatory adipokine with childhood metabolic syndrome (MS) and the effects of lifestyle interventions on circulating SFRP5 levels in children. Methods A study was conducted among 111 obese children and 49 lean controls,and the height,weight,waist circumference and blood pressure were measured.The blood lipid,blood glucose,and biochemical test were also tested.Venous blood was reserved to detect serum insulin,SFRP5,Wnt5a,hsCRP,leptin and adiponectin.A lifestyle intervention was performed in a subgroup of 31 obese children for 6 months.Indexes were measured at baseline and after lifestyle intervention. Results SFRP5 was significantly lower in obese children with MS compared with other two groups (P<0.05).SFRP5 was negatively correlated with homeostasis model assessment of insulin resistance (HOMA-IR) and leptin/adipo reception (LAR),and was positively correlated with adiponectin after control age and body mass index (BMI) (P<0.05).Furthermore,changes in BMI,blood pressure,HOMA-IR,triglyceride (TG),leptin,LAR were significantly increased,and SFRP5 and adiponectin were decreased after weigh loss intervention among 31children (P<0.05). Conclusions Serum SFRP5 is related with body lipid especially central obesity,lipid disorder,hypertension and hyperinsulinemia.It may be a beneficial adiposity factor which could improve the disorder of body.   
    Biomonitoring for exposure assessment of urinary para-nitrophenol among three-year-old children living in an agricultural county,Jiangsu province.
    GUO Jian-qiu,LV Shen-liang,LU Da-sheng,LIANG Wei-jiu,XU Hao,WU Chun-hua,ZHOU Zhi-jun.
    2016, 24(7):  682-685.  DOI: 10.11852/zgetbjzz2016-24-07-04
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    Objective To estimate exposure levels of urinary para nitrophenol (PNP) concentrations using biomonitoring data on 3-year-old children from an agricultural county,Jiangsu Province. Methods Questionnaires and spot urine samples were collected from 441 3-year-old children whose mothers participated our birth cohort study,which was named as "Effects of prenatal environmental chemicals exposure on the development of infants".The questionnaire survey included children's general demographic and socio-economic information and their lifestyles with potential exposure to PNP.Urinary PNP concentrations were measured using gas chromatography-tandem mass spectrometry (GC-MS/MS).Non-parametric test and multiple linear regression analysis were used to evaluate exposure of PNP. Results The PNP concentrations were detectable in all urinary samples.The geometric mean values of creatinine-adjusted and unadjusted were 12.14 μg/g cre.and 5.08 μg/L,respectively.Urinary concentrations of PNP in summer showed statistically higher than thoses of other seasons (P<0.05).No sex-specific difference was obtained in this study.PNP concentrations in children's urine were higher than other studies. Conclusions The findings suggested that the children are widely exposed to the PNP or precursor compounds at high levels in this county.The exactly biological mechanisms concerning the potential adverse effects on children deserve further investigations.   
    Dynamic analysis of secular trends on the quality of velocity and endurance among Tibetan primary and secondary school students aged 7 to 18 from 1985 to 2010.
    LIU Hui-bin,SONG Yi,MA Jun,ZHANG Bing,HU Pei-jin.
    2016, 24(7):  686-690.  DOI: 10.11852/zgetbjzz2016-24-07-05
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    Objective To analyze the secular trends on the quality of velocity and endurance among Tibetan primary and secondary school students from 1985 to 2010,and to provide scientific basis for taking effective measures to promote Tibetan students' physical fitness. Method The data collected by Chinese national survey on students' physical fitness and health from 1985 to 2010 were used to analyze the quality of velocity and endurance among Tibetan school students aged 7 to 18. Results From 1985 to 2010,50 m dash improved significantly among Tibetan students (P<0.01,0.76 s' faster among boys and 0.72 s' faster among girls),which improved by a big margin from 1985 to 1995,then on the basis of decline from 1995 to 2000,all students' performances got better since 2000.As for the quality of endurance,50 m×8 shuttle run improved significantly among students aged 7 to 12 (P<0.01,2.99 s' faster among boys and 5.03 s' faster among girls).In 1995,all students' performances reached a peak among 25 years,while decreased significantly in 2000,then got better since 2000.1 000 m run remained flat among boys aged 13 to 18,while 800 m run among girls dropped by an average of 5.28 s (P<0.01).All students' performances declined markedly since 1995,in particular with girls. Conclusion The quality of velocity among Tibetan students improved from 1985 to 2010,but we cannot be optimistic about the downward trend of the quality of endurance among students aged 13 to 18.   
    Analysis of the correlation between blood pressure level and lipid components among children and adolescent.
    JIANG Jia-jia,WANG Hong,ZHANG Fan,TIAN Yao,WEN Yu-tian,YANG Ying,WANG Ling-yi,CHENG Xu-ting.
    2016, 24(7):  691-694.  DOI: 10.11852/zgetbjzz2016-24-07-06
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    Objective To examine the correlation between blood pressure level and lipid components among children and adolescent. Methods A total of 2 009 children and adolescent aged 7~17 were included in the present study.Subjects were grouped by gender,correlation between blood pressure level and lipid components. Results Pearson correlation analysis showed:Blood pressure level was positively correlated with TC,TG / HDL-C,TC / HDL-C,non-HDL-C / HDL-C(P<0.05).Besides SBP of female,TC was positively correlated with SBP and DBP of male and DBP of female (P<0.05).TC / HDL-C was positively correlated with SBP and DBP of male and female (P<0.05).Besides DBP of female,HDL-C was negatively correlated with SBP and DBP of male and SBP of female (P<0.05).Stepwise regression analysis showed:SBP level of male was significantly correlated with TG,non-HDL-C,TG / HDL-C,non-HDL-C / HDL-C (P<0.05),while the DBP level was only significantly correlated with HDL-C (P<0.05).DBP level of female was significantly correlated with TG,TG / HDL-C,LDL-C / HDL-C,non-HDL-C (P<0.05),while SBP level was only significantly correlated with HDL-C (P<0.05). Conclusions To a certain extent,blood pressure level is correlated with lipid components among children and adolescent.And based on different gender,the correlation degree shows significant difference.   
    Comparative study on physical fitness of 7~18 years old Uygur children and adolescents between 2000 and 2010 in Xinjiang.
    KUANG Ming-liang,SUN Jian,MA Rong.
    2016, 24(7):  695-699.  DOI: 10.11852/zgetbjzz2016-24-07-07
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    Objective To grasp the changes of 7 to 18 years old Uygur children and adolescents' physical fitness in Xinjiang,and provide a scientific basis for improving the fitness level of Uygur children and adolescents. Method The physical research data of 2000 and 2010 Uygur children and adolescents in Xinjiang were used for statistical analysis for 7~18 year-old Uygur students' fitness index. Results Nearly 10 years,the rate quality of Uygur children and adolescents' physical fitness had increased,the other decreased.Compared with 2000,the urban male,rural male,urban female and rural female speed quality of Xinjiang Uygur students in 2010 increased 0.1,0.4,0.1 & 0.3 s;Endurance quality dropped 16.4,2.9,13.3 s & 2.3s;Explosive quality dropped 1.6,1.2,10.1 & 7.1 cm;In addition to urban male students flexibility quality increased 0.3cm outside flexibility quality,rural male,urban female and rural female dropped 0.5,0.4 cm & 0.7 cm,power quality dropped 11.6,7.7,13.0 b/m & 13.1 b/m;The most of all ages physical differences were statistically significant (P<0.05). Conclusions Nearly 10 years,the speed quality have improved,but endurance,explosive,flexibility and power quality have decreased in 7 to 18 years old of Uygur students in Xinjiang.Hence,complicated measures including school health education and physical training should be taken to improve their physical fitness.   
    Analysis of effectiveness of integrated early child development services combined with parent child paradise on the physical and intelligent developments of premature infants.
    XU Ming-fei,LIU Jie,ZHENG Juan,WENG Wen-wa.
    2016, 24(7):  700-704.  DOI: 10.11852/zgetbjzz2016-24-07-08
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    Objective To analyse the influences of integrated early child development services combined with parent child paradise on the physical and intelligent developments of premature infants,and explore ways to promote the physical and intelligent development of premature infants through community and family. Methods Using the methods of prospective cohort study,232 cases of premature infants with health examinations were checked in the child healthcare department of Kuangquan street community health service center in Yuexiu district of Guangzhou city from October 1,2011 to September 30,2012,were divided into 3 intervention groups[the integrated early child development services group (group Ⅰ),the parent child paradise services group (group Ⅱ),the integrated early child development services combined with parent child paradise services group (group Ⅲ)] and 1 control group[basic health services group (group Ⅳ)] in accordance with their parents' intend,and followed up to the correction of age of 12 months.All the premature infants were measured and compared the physical and the intelligent development levels in the correction of age of 3 months,6 months and 12 months. Results In the correction of age of 12 months,there were statistically significant differences in the physical development between group Ⅰ and group Ⅱ,group Ⅰ and group Ⅳ,group Ⅲ and group Ⅳ,group Ⅲ and group Ⅱ,but no statistically significant difference between group Ⅰ and group Ⅲ,group Ⅱand group Ⅳ.In the correction of age of 6 months or 12 months,there was statistically significant difference in intelligent development (except for the part of social behavior) between group Ⅰ and group Ⅳ(P<0.05),there was statistically significant difference in intelligent developments between group Ⅱ and group Ⅳ (P<0.05),there was obvious statistical significance difference in intelligent development between group Ⅲ and group Ⅳ (P<0.01). Conclusion Integrated early child development services combined with parent child paradise services could significantly improve the physical and intelligent development of premature infants.   
    Secular growth trends of Lisu adolescents from 1985 to 2014 in Yunnan province.
    HUANG Xin,CHANG Li-tao,HUANG Da-feng,AN Wei-wei,CHEN Lu,WEI Xi-jing.
    2016, 24(7):  705-708.  DOI: 10.11852/zgetbjzz2016-24-07-09
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    Objective To analyze the secular changes of Lisu adolescents from 1985 to 2014 in Yunnan province,in order to make effective intervention strategies and measures to improve their physical fitness and health. Methods Lisu students aged 7~18 years old participated in the 1985,1995,2005 and 2014 National Survey on Students Constitution and Health were used as subjects.The changes of height,weight,body mass index(BMI),maximum increment age(MIA),median menarcheal age(MMA) and median spermarcheal age(MSA) were analyzed. Results In recent 30 years,the overall increments of Lisu boys and girls were 4.5 cm and 6.0 cm for height,3.1 kg and 4.3 kg for weight,3.6 cm and -0.4 cm for adult height,0.3 kg/m2 and 0.3 kg/m2 for BMI(from 2005 to 2014),respectively.MIA of boys' and girls' advanced 1.13 years old and 3.17 years old.MSA advanced 0.40 years old from 2005 to 2014,MMA advanced 1.52 years old from 1985 to 2014. Conclusion Lisu adolescents in Yunnan province are experiencing the incomplete secular growth trend,some integrative measurements should be adopted according to the potential in secular changes of physical growth.   
    Influence of gestational diabetes in children physical development.
    JIANG Xin-ye,GUO Bing-bing,WEI Ya-rong,PEI Jing-jing,WANG Li-zhen,WANG Ya-jie.
    2016, 24(7):  709-711.  DOI: 10.11852/zgetbjzz2016-24-07-10
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    Objective To analyze nutritional status of women with gestational diabetes mellitus(GDM) and physical development of the offsprings of GDMs(OGDM),and to provide theoretical support for scientific and early nutrition interventions. Methods Totally 339 women with GDM and their babies were investigated,there after 114 of them were followed up at 6 months of age.The physical examinations of children were completed by trained health staff to collect growth parameters. Results Logistic regression analysis showed that after the adjustment for gender,maternal age and other confounding factors,poor glycemic control during pregnancy (OR=4.44,95%CI:1.69~11.69) was identified to be associated with low birth weight; maternal pre-pregnancy BMI (OR=1.18,95%CI:1.06~1.30) and gestational weight gain (OR=1.11,95%CI:1.04~1.18) were effect factors of macrosomia.Neonatal birth weight and maternal pre-pregnancy BMI,gestational weight gain had significant positive correlation (P<0.05);The weight-for-age Z scores (WAZ) and height-for-age Z scores (HAZ),bmi-for-age Z scores (BAZ) at 6 months were positively associated with neonatal birth weight (P<0.05).Pre-pregnancy BMI,gestational weight gain,neonatal birth weight were influencing factors of cesarean section. Conclusions OGDM had higher numbers of low birth weight and macrosomia.Ideal glycemic control during pregnancy can reduce the occurrence of low birth weight and macrosomia.To prevent long-term complications of OGDM,perinatal care should be strengthened.More importantly,these newborns should be included in the management system of high risk children from birth,their nutritional status and physical development and growth also should be closely monitored.   
    Effect of vitamin D receptor expression in the thymus of filial generation mice after giving pregnant vitamin D.
    WANG Zhi-hui,ZHAO Xia-xia,REN LI-hong.
    2016, 24(7):  712-714.  DOI: 10.11852/zgetbjzz2016-24-07-11
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    Objective To detect the changes of vitamin D receptor (VDR) expression in the thymus of filial generation mice after giving pregnant mice different dosages of vitamin D supplementation. Methods Totally 18 female Wistar mice mates with 9 male Wistar mice at 5 pm everyday (the female/male radio was 2∶1).The vaginal secretions of the female mice were collected and made into smears.Conception was recorded after finding sperm in the smears,noting gestational day 0 (GD0).The pregnant mice were separated into three groups:control group,low level of vitamin D supplementation group and high level of vitamin D supplementation group.Different dosages of vitamin D supplementation were given by intramuscular injection from GD 15,with normal saline 0.25 ml/kg,vitamin D 20 μg/kg and vitamin D 100 μg/kg separately for each group.The injection continued until delivery.After 21 days breast-feeding,the thymus of filial generation mice were isolated.The expression of VDRmRNA was detected by Real-time PCR and the expression of VDR protein was detected by Western blot. Results No statistic difference of VDR gene expression was observed among different groups by Real-time PCR(P>0.05).Western blot showed that the expression of VDR protein in low level of vitamin D supplementation group and high level of vitamin D supplementation group was higher than that of the control group (P<0.05). Conclusion The expression of VDR in filial generation mice increases if mother mice are given vitamin D supplementation during pregnancy and is positively related to the dosage of vitamin D supplementation.   
    Effect on depth of protein hydrolysate formula milk to children's nutritional status of henoch-schonlein purpura.
    WANG Li,XUE Wan-li,MAO Hua,HAO Hui-xiang,WEI Fei,MAO Jin.
    2016, 24(7):  732-734.  DOI: 10.11852/zgetbjzz2016-24-07-17
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    Objective To investigate the effect of depth of protein hydrolysate formula milk to children's nutritional status of henoch-schonlein purpura,looking for a balanced diet treating for children. Methods Totally 60 children with allergic purpura visiting the clinic of the pediatric department were consecutively recruited from January 2014 to June 2015.Patients were randomly divided into restricted diet group(30 patients receive traditional restricted diet)and deep hydrolysis group (30 patients receive depth of protein hydrolysate formula milk).30 cases with upper respiratory tract infection who had normal diet were selected as control group in the same period.All children were investigated the dietary per month after diet treating,blood biochemical test,total of 3 times.The differences of food intake,nutritional status were compared between different groups. Results After diet treating three months,the actual intake/recommend of most nutrient was still less than 60% in restricted diet group,total nutrient intake reached 90%~110% in deep hydrolysis group.Serum triglycerides,cholesterol,prealbumin,total protein and albumin levels were higher in deep hydrolysis group compared with restricted diet group,and there was no statistical difference between deep hydrolysis group and control group. Conclusion Depth of protein hydrolysate formula milk can improve nutrients and protein intake of HSP children,is helpful to the healthy growth of children.   
    Early effect of different feeding ways on the growth and development of infants.
    CUI Yi-fan,ZHANG Bei,XIAO Xu-wu.
    2016, 24(7):  735-738.  DOI: 10.11852/zgetbjzz2016-24-07-18
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    Objective To explore the effects of pure breast-feeding and artificial feeding on the physical,mental,motor,temperament development of term infant and preterm infant at 6 months of age,and prove the importance of breastfeeding for infant growth and development and provide theoretical basis to promote breastfeeding. Methods Totally 97 term infants and 67 preterm infant were chosen for this study.According to their feeding types,they were assigned into 4 groups:pure breastfeeding term infant group (group A,n=54);artificial feeding term infant group(group B,n=43);breastfeeding preterm infant group (group C,n=38);artificial feeding preterm infant group (group D,n=29).Weight,length and head circumference of A,B,C,D four groups in birth,42 days,two months,three months,six months were measured and calculated the net value.CDCC Scales of Infant Development was used to evaluate their neurodevelopment at age 6 months.The result was indicated as mental development index(MDI),psychomotor development index(PDI).Infant Temperament Scale Standardized in China was used to check the temperament type and nine dimensions of the all infants. Results Aspects of growth and development,net weight of breastfeeding babies in 42 days,42 days ~2 months,2~3 months three time periods were greater than the values of artificial feeding,and the difference was statistically significant (P<0.05);For full-term children,corresponding length and head circumference of the breastfeeding babies in 2~3 months,3~6 months to two time periods and born~42 days,2~3 months the two time periods,had more added value than the artificial feeding.For premature children,the breastfeeding were born~42 days,42 days~2 months,2~3 months,3~4 months four time periods and 42 days~2 months,2~3 months the two time periods,corresponding to the length and head circumference had more added value in beastfeeding than those in the artificial feeding.Breastfed babies' the intellectual,physical development index measured six months after birth were higher compared with artificial feeding.Breastfeeding and artificial feeding formed no difference in temperament in children. Conclusions Exclusive breastfeeding benifits both the mental development index and psychomotor development index in 6 months term children when compared with pure artificial feeding,the physical development advantages mainly concentrate in the first 3 months after born.Exclusive breastfeeding in 6 months term and preterm infants have no significant association with temperament.
    Analysis of the detection results of 4 317 cases of breast milk composition in Weinan city.
    CAO Min-hui,AN Qi,LI Yan,CHAO Dong-ling.
    2016, 24(7):  739-741.  DOI: 10.11852/zgetbjzz2016-24-07-19
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    Objective To analyze the mature breast milk composition in Weinan City,and to provide the basis for guiding the work of breastfeeding in this region. Method Healthy lactating women mature breast milk samples were collected using the MIRIS HMA Milk Analyzer ",to detect the macro nutrient content and analyze results and the related factors. Results The subject included 4 317 samples,the composition of fat,proteins,carbohydrates,drymatter,energy were dynamic.The nutritional components of the milk also changed by baby months increasing.The fat and dry matter decreased but the changes were not significantly (P>0.05),proteins and energy were decreased significantly by the month of age (P<0.05).Carbohydrate was increased,but differences were not significant by the month of age (P>0.05). Conclusions The nutrients in breast milk were dynamic changed,relationships of milk composition level and maternal age,infant sex were not obvious,macro nutrient elements in local district mature milk contains,protein,fat,energy content except carbohydrate were higher than results of domestic and foreign areas.
    Analysis of the growth and development Trend of different gestational age preterm infants.
    JIANG Wen,QIU Shuang-yan,JIANG Xue-ming,HE Hui-jing,WAN Guo-bin.
    2016, 24(7):  742-745.  DOI: 10.11852/zgetbjzz2016-24-07-20
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    Objective To investigate the physical,motor and intelligent development trend of premature infants of different ages until 24 months old,and to provide a basic theory for early intervening premature infants. Methods A total of 82 premature infants were divided into two groups (more than or equal to 32 weeks in late preterm infants group and less than 32 weeks in early preterm infants group),and followed up regularly.The premature infants' physical,motor and intelligent developments were assessed at 6,12,18,24 corrected months. Results 1)Physical development had statistically differences between two groups at 6 months of age on weight,length and head circumference.The weight component ratio difference was continued until to corrected age of 12 months.2)Psychomotor developmental index (PDI) of two groups in corrected age of 6 and 12 months were significantly less than 85 points,and the gap to 85 points of early preterm group was bigger,while both of them were up to 85 or more points without correction at 18 months corrected age.3)Mental developmental index (MDI) of two groups in corrected age of 6,12 and 18 months were significantly less than 85 points,and the gap to 85 points of early preterm group was bigger,while both of them were up to 85 or more points without correction at 24 months corrected age. Conclusions Catch-up growth of early preterm infants within a year was not enough and the weight is outstanding.It recommends strengthening early fortified group of preterm infants.Motor and intelligence development level in the two groups within corrected age of 24 months was obviously lower than children of the same age,and they can catch up with children of the same age at the corrected age of 24 months.Motor and intelligence development of premature infants in two groups showed a catch-up development trend within corrected age of 24 months.
    Related factors of physical growth retardation and related factors in preterm infants.
    ZHANG Yong,WAGN Zhao-hui.
    2016, 24(7):  746-748.  DOI: 10.11852/zgetbjzz2016-24-07-21
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    Objective To evaluate the physical growth retardation of premature infants and analyze the possible influencing factors. Methods The results were analyzed on 183 cases of premature infants meeting the selecting conditions,who visited doctors from March 2012 to July 2014 in Xi'an NO.4 Hospital and were followed-up to 1 year old as well. Results 1) By analyzing the weight,length and head circumference,the ratios of growth retardation at birth were respectively 21.3%,15.3%,18.03%,the ratios of the extra uterine growth retardation (EUGR) were 21.9%,11.48%,16.39% for corrected 40 weeks;9.8%,4.92%,3.28% for 3 months;8.7%,4.37%,4.92% for 6 months;8.7%,2.73%,4.92% for 9 months;8.2%,3.83%,3.83% for 12 months.The differences of the ratio of the growth retardation were statistically significant compared with different stages.2) By analyzing the weight,length and head circumference of 6 months,the intrauterine growth retardation (IUGR),birth weight,feeding way and the length of days were risky factors of growth retardation.However,gestational age was not the risky factor. Conclusions The most effective interventive time period should be corrected gestational age within the first 3 months.To strengthen the prenatal care and reduce the incidence of intrauterine growth retardation and extremely low birth weight,shorten the hospitalizate days is the key to prevent the extrauterine growth retardation.
    Monitor and follow-up on physical growth and development of post-discharge preterm infants.
    LI Xiao-yan,WANG Hui-qin,CHAI Zhu-qing,WANG Jia-an,LIANG Xiu-yun,YANG Rong,TONG Ling,GUO Ben-biao,YIN Xiao-guang.
    2016, 24(7):  749-751.  DOI: 10.11852/zgetbjzz2016-24-07-22
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    Objective To explore the features of physique and motor development of preterm infants at the corrected age of 18 months and provide the theoretical basis for the improvement of their health related quality of life. Methods A prospective cohort study was performed from 2012 to 2015 at the following-up center of high-risk children in Maternal and Child Health Care Hospital,with 174 preterm infants and 183 term infant as the control group.Physique and motor development parameters were compared at the corrected age of 6,12 and 18 months,respectively. Results Preterm infants developed statistically significant worse on weight,length and head circumference at the corrected age of 6 months (P<0.01).Although,there was no difference in gross motor scores for the preterm infants at corrected age of 12 and18 months compared with the term infants.However,the preterm infants hadn't caught up with especially those who was small for gestational age (P<0.05) in the term of fine motor development and language and person society and adaptive behavior. Conclusion Preterm infants at the corrected age of 6 months hadn't caught up with the term ones,especially growing potential of who was small for gestational age was less than those appropriate for gestational age.Adequate nutrition and intelligent training for the preterm infants at the early stage might have potential value on the improvement of their life qualify.   
    Drinking patterns and socioeconomic determinants of binge drink among high school students in Guangzhou.
    LIN Rong,CHEN Si-yu,LIU Wei,LIU Wei-jia.
    2016, 24(7):  752-755.  DOI: 10.11852/zgetbjzz2016-24-07-23
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    Objective To examine the drinking patterns and associations between socioeconomic status (SES) and adolescents'alcohol use among Guangzhou senior high school students. Methods Using a self-administered questionnaire,a cross-sectional survey was conducted among 3 282 senior high school students from 20 schools between May and June 2013. Results The prevalence of lifetime drinking was 75.61%,60.22% of the participants were past-year drinkers,while 22.75% of them had consumed alcohol in the past 30 days.During the past 30 days,7.17% of the adolescents reported that they drank at least 6 drinks on one occasion,and 27.67% of the students had drunk until intoxication in the past year.Overall,the prevalence of the five above drinking behaviors of boys were higher than those of girls.Multiple regression analyses were used to investigate the independent effect of SES indicators on binge drink and drunkenness.For the students from more affluent families or with low academic grade,the adjusted odds of binge drink and drink until intoxication were significantly higher,compared with those who from less affluent families or with high academic grade. Conclusion Due to the high prevalence of the alcohol consumption among senior high school students in Guangzhou,it is important to have early education and intervention in order to reduce alcohol availability and drinking among adolescents.   
    Nutrition status and its influence factors in children at age of 6~24 months in Gansu rural areas.
    ZHANG Ya-nan,ZHANG Ben-zhong.
    2016, 24(7):  756-758.  DOI: 10.11852/zgetbjzz2016-24-07-24
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    Objective To examine nutrition status and its influence factors in children at age of 6~24 months among different ethnic populations in rural areas of Gansu province. Methods A total of 12 counties were selected by multi-stage stratified cluster sampling method in Gansu province,and physical measurement surveys of 3 663 children at age of 6~24 months and questionnaires of children caregivers were collected during December 2014 to January 2015. Results The prevalence of malnutrition was 21.3% of children aged 6~24 months in Gansu province,and the prevalence of overweight,wasting,underweight and stunning were 7.0%,4.0%,3.2% and 7.0% respectively.Single factor analysis showed the influence factors of malnutrition including gender,anemia status,preterm birth,birth length and birth weight,caregivers' education and occupation,feeding style within six months,time and type of adding assist food.Multifactor analysis showed that gender,age,preterm birth,scores of caregivers' nutrition and health knowledge,caregivers' occupation,adding time and type of assist food were significant influence factors. Conclusions The overall nutrition status of infants aged 6~24 months in Gansu province shows an improving trend.But stunning remains a major malnutrition concern,special attention would be paid to intervention of a high prevalence of overweight.Integrated measurements should be carried out to improve growth and development of children.   
    Efficacy observation of ultrasound-guided botulinum toxin type A injection combined with routine rehabilitation training on lower limbs dysmyotonia of spastic cerebral palsy children.
    ZHANG Yan-jiao,TONG Guang-lei,ZHOU Tao-cheng,YI Xin,CAO Hong-yao,MA Qi-zhou.
    2016, 24(7):  759-761.  DOI: 10.11852/zgetbjzz2016-24-07-25
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    Objective To observe the clinical effect of ultrasound-guided botulinum toxin type A (BTX-A) injection combined with routine rehabilitation training on lower limbs dysmyotonia of spastic cerebral palsy children,and to provide evidence for clinical recovery treatment. Methods A total of 42 cases of Cerebral palsy in rehabilitation department of Anhui Provincial Children's Hospital from September 2014 to August 2015 were randomly divided into treatment group with 21 cases and control group with 21 cases,the control group received routine rehabilitation training (exercise therapy and physical therapy),treatment group was treated with BTX-A injection with ultrasound positioning and guidance,and began routine rehabilitation training next day.All patients were evaluated respectively before treatment and one month,three months,six months after treatment,the Modified Ashworth Scale(MAS)and the Gross Motor Function Measure(GMFM) were used as the standard to assess the degree of muscle spasm and gross motor function of lower limbs. Results After one month,three months and six months treatment,the MAS and GMFM scores of two groups were all significantly better than before (P<0.05);At the same time point,compared with the control group,the degrees of spasm and motor function in the treatment group were significantly improved (P<0.05);The MAS score improvement of treatment group between three months and six months after treatment was statistically significant (P>0.05),BTX-A effect had a certain time limit. Conclusion The use of BTX-A with ultrasound in the treatment of spastic cerebral palsy children can relieve the muscular tension,and improve the motor function.   
    Effect of mycoplasma pneumonia infection on pulmonary function in children with bronchial asthma.
    ZHOU Cai-li,LIU Zong-wei,ZHOU Qing-xia,DUAN Quan-ji.
    2016, 24(7):  762-764.  DOI: 10.11852/zgetbjzz2016-24-07-26
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    Objective To explore the effect of mycoplasma pneumonia infection on pulmonary function in children with bronchial asthma,and provide objective basis for clinical treatment and prognosis assessment. Methods The clinical data of asthmatic children who were diagnosed and treated in our hospital from October 2013 to October 2015 were retrospectively analyzed.576 cases who have received pulmonary function test in the acute phase of treatment for one week were divided into two groups:positive group (asthma with mycoplasma pneumoniae infection group,144 cases)and negative group (asthma without mycoplasma pneumoniae infection,432 cases).Then the pulmonary ventilation function check indexes were analyzed by statistical software. Results 1)Comparison between negative group and positive group:about the lung ventilation function of two groups,positive group's forced vital capacity (FVC) was higher than that of negative group,the first second forced expiratory volume/forced vital capacity (FEV1 %) was lower than that of the negative group,and there was no statistically significant difference between them;Besides,first second forced expiratory volume (FEV1),peak expiratory flow (PEF) and maximal expiratory flow (MMEF) 25-75,PEF25,PEF50 in positive group were lower than those in negative group,and there were statistically significant differences (P<0.05),giving priority to MMEF 25-75.2)Comparision within positive group:children in the positive group were divide into the high titer group and the low titer group according to mycoplasma pneumoniae antibody titer.And there was no statistically significant difference between the two groups about the lung ventilation function (P>0.05). Conclusion Mycoplasma pneumoniae infection can reduce pulmonary function in children with asthma,giving priority to increasing the small airway obstructive pathological changes,so it is necessary to pay more attention to asthma children with mycoplasma pneumonia infection.   
    Analysis of clinical characteristics in preterm and term infants with sepsis.
    LI Qing-hong,HE A-ling,YANG Jun-lan,GUO Jin-zhen,ZENG Jun-an,LI Zhan-kui.
    2016, 24(7):  765-766.  DOI: 10.11852/zgetbjzz2016-24-07-27
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    Objective To evaluate the clinical characteristics of neonatal sepsis in preterm and term infants. Methods A total of 97 preterm and 43 term neonatal sepsis were retrospectively analyzed. Results Early-onset sepsis was higher in preterm neonatal sepsis than that in term neonatal sepsis (P<0.01).Conversely,late-onset sepsis was higher in term neonatal sepsis than that in preterm neonatal sepsis (P<0.01).Comparing with term neonatal sepsis,preterm neonatal sepsis tended more to accompany premature rupture of membranes,caesarean section,PICC catheterization,umbilical vein catheterization and intravenous nutrition (all P<0.01).Possibilities of mother perinatal infection,meconium-stained amniotic fluid and natural labor in term neonatal sepsis were higher than those in preterm neonatal sepsis (all P<0.01).Preterm neonatal sepsis tended to have low response,feeding intolerance,abdominal distension,apnea,dyspnea and ventilation treatment (all P<0.05 or <0.01).Term neonatal sepsis tended to have abnormal temperature,pathologic jaundice and skin infection (all P<0.01).Preterm neonatal sepsis was susceptible to complicate with infectious shock and neonatal necrotizing enterocolitis (P<0.01,<0.05).Their white blood cells and platelet obviously decreased (all P<0.01). Conclusions Sepsis in preterm and term infants is somewhat different in clinical manifestations and laboratory tests.Preterm neonatal sepsis often involves multiple systemic changes.
    Observation on the effect of early exercise intervention on fetal growth restriction.
    HUANG Xiu-juan,SONG Juan,ZHU Jin-yuan,YANG Cui-ping,YANG Yue.
    2016, 24(7):  767-769.  DOI: 10.11852/zgetbjzz2016-24-07-28
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    Objective To investigate the effect of early exercise intervention on fetal growth restriction(FGR) about intelligence and psychomotor development. Methods From July 2012 to July 2013,240 cases of FGR were divided into two groups,intervention group and not-intervention group.120 natural infants in normal control group at the same time .The intervention group was given priority to the implementation of exercise intervention,with drug therapy,physical therapy,music therapy,making periodical medical examination and intelligence evaluation. Results 1)Average scores of mental development index(MDI) and psychomotor development index (PDI) in intervention group were significantly higher than those in not-intervention group (P<0.001).2)The sequelae of intervention group after intervention were significantly less than those of the not- intervention group.3)Intervention group could catch up with normal control group with no significant difference when they were two year old(P>0.05). Conclusion Early exercise intervention can promote the development of FGR,improve the quality of life and reduce the burden on society.   
    Intervention study on anemia among 6~24 months young infants in three counties of Guangxi.
    WEI Ping,QIU Xiao-xia,ZUO Meng-ling,CHEN Yue-hua,MENG Xiao-mei.
    2016, 24(7):  770-772.  DOI: 10.11852/zgetbjzz2016-24-07-29
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    Objective To understand the distribution of anemia among 6~24 months young infants in 3 counties of Guangxi where the incidence of anemia were high,and analyse the influence of different intervention methods on the 6~24 months young infants. Methods The survey was conducted according to stratified cluster sampling method in regions with a high incidence of anemia in Guangxi.Finally,504 aged 6~24 months infants with their parents were extracted from 3 counties and 8 townships and divided into A,B,C,D 4 groups to carry out a questionnaire survey and different intervention trials.Also,comparative analysis anemia and outcomes were carried out before and after the intervention. Results The 4 groups had no statistically significant differences (χ2=0.56,P=0.905) in gender but had statistically significant differences in prevalence of anemia(χ2=13.81,P=0.003);Order of prevalence of anemia showed B>A>D>C.The prevalence of anemia was decreased after intervention trials(P<0.001).Later order changed as C>D>A>B.Before and after intervention,there was also with statistical significance (χ2=26.64,P<0.001)in the outcomes of anemia. Conclusion Supplementary nutrient for 6~24 months young infants is conducive to improving the status of anemia and reduce the prevalence of anemia.   
    Relationship of constant and trace element of 0~13 years old children in Yuexiu district of Guangzhou.
    HONG Bin,ZHANG Jian-jun,LIN Hong-yi,CHEN Xiao-li.
    2016, 24(7):  773-775.  DOI: 10.11852/zgetbjzz2016-24-07-30
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    Objective To analyze the current levels of lack situation of blood constant elelments of 0~13 years old children in Yuexiu district,Guangzhou. Method The constant and trace elements of 3 475 children aged 0~13 years old were measured and compared. Results Zinc and calcium were in the biggest need.Zinc ranked the first(24%)in the four age groups,and calcium ranked second(6.1%).The absent rate of calcium increased by the ages,and the absent rate of zinc decreased by the ages,especially in infants.There was no significant difference of these five constant elements between boys and girls. Conclusions Lack of some constant and trace elements are common and related of diet behavior.The relevant media should be proposed in the diet structure and correcting bad diet behavior.Regular inspection,adjust diet structure or add reasonable drug timely based on ages and genders are needed.
    Influence of breastfeeding on the blood of children with phenylketonuria phenylalanine.
    WU Wan-liang,LI Feng-xia,SHI Yan.
    2016, 24(7):  776-778.  DOI: 10.11852/zgetbjzz2016-24-07-31
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    Objective To research on phenylketonuria children in low-phenylalanine milk treatment,comparison of breast milk and formula milk on blood phenylalanine values. Methods Children patients who had been diagnosed of phenylketonuria by Neonatal Disease Screening Center of Northwest Women and Children Hospital from January to December 2012 were retrospectively analyzed.The patient were divided into breast feeding group(n=68)and formula milk feeding group(n=20)according to the feeding pattern,and the blood phenylalanine values and the condition of growth and development regulary were observed. Results The mean blood phenylalanine values of 60 patients ( 88.24%) in breast feeding groups were in normal range,however only 13 patients (65.00%)in formula milk feeding groups,the rate was statistically different(χ2=4.372,P<0.05).The T value of height,weight and intelligence development of two groups were 0.17,2.42 and 2.7,there was no significantly difference(P>0.05). Conclusion There are different effects between breast feeding group and formula milk feeding group in treatment of patients with phenylketonuria,the breast feeding may contribute to control the blood phenylalanine values of patients with phenylketonuria.   
    Investigation on nutrition knowledge attitude and practice of 4~6 grades pupils in Changzhi.
    DUAN Pei-fen,ZHAI Yan-li,FENG Xiang-xian,YUAN Jian-hui.
    2016, 24(7):  779-781.  DOI: 10.11852/zgetbjzz2016-24-07-32
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    Objective To understand the status of pupils' nutrition knowledge attitude and practice in Changzhi and propose health education and promotion measures. Methods A total of 1 265 students were collected from 4~6 grades by random cluster sampling method to conduct a questionnaire survey for nutrition status. Results It showed that the correct answer rate of some nutrition knowledge questions was over 60%,while the correct answer rate of other ones was lower.It was 6.32% and 7.43% respectively.There were significant differences in eating frequency of fried,pickled,barbecue food between health education students and non health education students.The pupils obtained the nutrition knowledge from internet and television and they were willing to obtain the nutrition knowledge from teacher. Conclusions The rate of nutritional knowledge of primary school students in Changzhi was higher,but there were some deviations.Multiple health education should be used to help them develop good eating habits.