Abstract: Objective To study the difference of serum 25-hydroxyvitamin D(25-(OH)D) level between children with severe pneumonia and healthy children,and to provide a theoretical basis for vitamin D supplementation to reduce the incidence of severe pneumonia.Methods Using case-control study,sixty-four children with severe pneumonia treated in Department of Pediatrics of the Affiliated Hospital of Yan'an University from January 2014 to December 2016 were selected as severe pneumonia group,and sixty healthy children with the same age in the same period of physical examination were selected as healthy control group.The levels of serum 25-(OH)D in the two groups detected by chemiluminescence method were analyzed.Results Serum 25-(OH)D levels in children with severe pneumonia were significantly lower than those in healthy controls (P<0.01);The constituent ratios of normal (9%) and deficiency (19%) of vitamin D in severe pneumonia group were significantly lower than those in healthy control group (33%,42%,all P<0.05).While the ratios of deficiency (38%) and sever deficiency (30%) in severe pneumoria group were significantly higher than those of the healthy control group (15%,10%,all P<0.01).Conclusions Vitamin D deficiency is prevalent in children.Serum 25 (OH) D level in children with severe pneumonia is significantly lower than that in healthy children.Vitamin D supplementation in reducing the morbidity of severe pneumonia in infants and young children is still to be further studied.

Key words: vitamin D, severe pneumonia, children, serum 25 (OH) D levels

摘要： 目的 观察重症肺炎患儿与健康儿童血清25-羟基维生素D[25-(OH)D]水平的差别,为补充维生素D减少重症肺炎发生率提供理论基础。方法 采用病例对照研究方法,选取2014年1月-2016年12月期间在延安大学附属医院儿科住院治疗的64例重症肺炎患儿为重症肺炎组,另外选取60例同年龄段同时期进行健康体检的儿童为健康对照组。应用化学发光法检测两组儿童血清25-(OH)D水平并进行比较。结果 重症肺炎组患儿血清25-(OH)D水平明显低于健康对照组(P＜0.01);重症肺炎组维生素D正常(9%)、不足(19%)的构成比均显著低于健康对照组(分别为33%、42%,P均＜0.05),而缺乏(38%)、严重缺乏(30%)的构成比均显著高于健康对照组(分别为15%、10%,P均＜0.01)。结论 维生素D不足在儿童中普遍存在,重症肺炎患儿血清25-(OH)D水平显著低于健康儿童,补充维生素D对降低婴幼儿重症肺炎发病率的意义有待进一步研究。

关键词: 维生素D, 重症肺炎, 儿童, 血清25-(OH)D水平