journal1 ›› 2018, Vol. 26 ›› Issue (3): 325-328.DOI: 10.11852/zgetbjzz2018-26-03-27

Previous Articles     Next Articles

Analysis of related factors for multiple drug resistant bacteria infection in children with severe bacterial pneumonia

XIE Zhao-yun1,2, XIONG Yun1, QIN Jia-lu1, YANG Zhong-ling3, HU Yang3   

  1. 1 Management of Hospital Infection 2 Microbiology Laboratory 3 Clinical Lab,the Third Affiliated Hospital of Guizhou Medical University,Duyun,Guizhou 558000,China
  • Received:2017-07-01 Online:2018-03-10 Published:2018-03-10


谢朝云1,2, 熊芸1, 覃家露1, 杨忠玲3, 胡阳3   

  1. 贵州医科大学第三附属医院1 感染管理科
    2 微生物学实验室
    3 检验科,贵州 都匀 558000
  • 基金资助:

Abstract: Objective To analyze the related factors of multiple drug resistant bacteria infection in children with severe bacterial pneumonia. Methods A retrospective analysis was conducted from January 2011 to November 2015 to collect clinical data of 457 cases of children with bacterial severe pneumonia including 96 cases of multi drug resistant bacteria infection patients and 361 cases of non multi drug resistant bacteria infection of difference.Related factors analyzed by multivariate Logistic regression analysis. Results A total of 96 patients were with multi drug resistant strains of bacteria,including 68 males,28 females,aged 0~14 years old,and the average age was(6.09±4.51) years old.And 361 patients were without multi-drug resistant strains of bacteria,including 228 males,133 females,the average age was (5.34±4.63) years old.Multifactors analysis showed that the previous use of antimicrobial agents[OR=1.093,95%CI(1.014~1.179)],in PICU days [OR=3.613,95%CI(1.874~6.969)],and traumatic treatment after infection [OR=2.296,95%CI(1.141~4.619)],combined application of antibiotics [OR=6.861,95%CI(3.510~13.409)],antibiotic use days after infection [OR=1.295,95%CI(1.125~1.409)] were the main factors of multi drug resistant bacteria infection in children with severe bacterial pneumonia (P<0.05). Conclusion Effective measures should be taken to prevent and reduce the multiple drug resistant bacteria infection in children with bacterial pneumonia.

Key words: bacteria, severe pneumonia, multi-drug resistant bacteria, risk factors, children

摘要: 目的 分析儿童细菌性重症肺炎患者多重耐药菌感染的相关因素。方法 回顾性分析2011年1月-2015年11月457例儿童细菌性重症肺炎患者的临床资料,比较其中96例多重耐药菌感染患者与361例非多重耐药菌感染患者的差异,并进行多因素Logistic回归分析。结果 检出多重耐药菌菌株的患者96例,男68例,女28例,年龄0~14岁,平均(6.09±4.51)岁;未检出多重耐药菌菌株的患者361例,男228例,女133例,年龄0~14岁,平均(5.34±4.63)岁。多因素分析显示,既往使用抗菌药物天数[OR=1.093,95%CI(1.014~1.179)]、入住PICU[OR=3.613,95%CI(1.874~6.969)]、创伤性治疗[OR=2.296,95%CI(1.141~4.619)]、感染后联合应用抗菌药物[OR=6.861,95%CI(3.510~13.409)]、感染后使用抗菌药物天数[OR=1.295,95%CI(1.125~1.409)]是儿童细菌性重症肺炎多重耐药菌感染的主要因素(P<0.05)。结论 应针对相关危险因素采取有效防治措施,减少儿童细菌性肺炎患者多重耐药菌感染。

关键词: 细菌, 重症肺炎, 多重耐药菌, 危险因素, 儿童

CLC Number: