Research progress on the genetics of developmental dyslexia susceptibility gene KIAA0319 and DCDC2

doi:10.11852/zgetbjzz2019-0437

Abstract

Abstract: Developmental dyslexia (DD) in children is a polygenic genetic disease with complex etiologies,controlled by multiple genes interacting with each other.In recent years,multiple susceptible genes have been gradually identified since the researches on genetic behavior of dyslexia.This paper mainly focuses on chromosome 6 to review the common candidate genes for dyslexia,including DCDC2,KIAA0319 and their interactions,so as to provide reference for exploring the mechanism of dyslexia from the perspective of "gene-brain-behavior".

Key words: developmental dyslexia, DCDC2, KIAA0319, interaction

摘要： 儿童发展性阅读障碍(DD)是一种病因复杂的多基因遗传病,受多个遗传基因的控制,而且基因间也存在交互作用,近年来随着发展性阅读障碍的遗传行为学研究,多个易感基因逐步被识别。本文主要围绕6号染色体,对发展性阅读障碍常见的候选基因DCDC2、KIAA0319及两者间的交互作用进行综述,为从“基因-大脑-行为”方面探究发展性阅读障碍的机制提供依据。

关键词: 发展性阅读障碍, DCDC2, KIAA0319, 交互作用

CLC Number:

R749.94

ZHAO Hua, LIU Rui-fang, SHI Hong-juan, ZUO Peng-xiang. Research progress on the genetics of developmental dyslexia susceptibility gene KIAA0319 and DCDC2[J]. journal1, 2020, 28(3): 284-287.

赵华, 刘瑞芳, 史红娟, 左彭湘. 阅读障碍易感基因KIAA0319和DCDC2遗传学研究进展[J]. 中国儿童保健杂志, 2020, 28(3): 284-287.

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