Abstract: Objective To evaluate effect of sublingual dermatophagoides farinae drops combined with standardized treatment in children with asthma. Methods A total of 110 children aged 6~14 years old with out acute exacerbation of mild - moderate allergic asthma from department of allergy of Fuzhou Children's Hospital from October to December in 2009 were selected and divided randomly into experimental group and control group of 55 cases each.The experimental group was given sublingual dermatophagoides farinae drops combined with inhaled corticosteroids standardized treatment,control group was given only inhalation therapy of hormone regulation.2 years of follow-up,the number of respiratory tract infections and asthma attacks,the children missed school days,the results of lung function FEV1%,FEF25%,FEF50% and inhaled corticosteroid dose were compared before and after treatment. Results 1) No significant difference was found in the pulmonary function (FEV1%,FEF25%,FEF50%) between the two groups before the treatment (P＞0.05);The pulmonary function indexes of the experimental group were significantly higher than the control group after treatment(P＜0.05);The pulmonary function indexes of the experimental group after treatment were significantly higher than those of before treatment (P＜0.05);2) The number of respiratory tract infections and asthma attacks,the children missed school days in experimental group significantly reduced than the control group after treatment (P＜0.05);3) The inhaled corticosteroid dose in experimental group significantly reduced than the control group after treatment (χ²=9.072,P=0.028). Conclusion The effector of sublingual dermatophagoides farinae drops standardized treatment combined inhaled hormone is better than single treatment with inhaled corticosteroid.

Key words: asthma, children, immunotherapy;dust mite, pulmonary function, corticosteroids

摘要： 目的 评价舌下含服粉尘螨滴剂在儿童哮喘中的作用,为临床治疗提供有效途径。方法 2009年10-12月福州儿童医院变态反应科门诊110例6~14岁非急性发作期轻-中度过敏性哮喘儿童,随机分成实验组和对照组各55例。实验组采用舌下含服粉尘螨滴剂联合吸入激素规范化治疗,对照组仅采用吸入激素规范化治疗方案。随访两年,比较两组治疗前后呼吸道感染次数、哮喘发作次数、儿童误学天数、肺功能FEV1%、FEF25%、FEF50%结果和吸入激素剂量。结果 1)治疗前实验组和对照组肺功能(FEV1%、FEF25%、FEF50%)差异无统计学意义(P＞0.05);治疗后实验组肺功能各指标较对照组明显升高(P＜0.05);实验组治疗后肺功能各指标较治疗前明显升高(P＜0.05);2)治疗后实验组呼吸道感染次数、哮喘发作次数、儿童误学天数较对照组明显减少(P＜0.05);3)治疗后实验组吸入激素剂量较对照组明显减少(χ²=9.072,P=0.028)。结论 舌下含服粉尘螨滴剂联合吸入激素规范化治疗效果优于单用吸入激素。

关键词: 粉尘螨, 肺功能, 糖皮质激素, 哮喘, 儿童, 免疫治疗