Abstract: Objective To explore status quo of Shanghai school-age children exposed to bisphenol A (BPA) and the relationship between BPA exposure with children obesity. Method A total of 500 primary school students aged between 6 and 11 were collected,used high performance liquid chromatography (HPLC) method to detect the concentration of total BPA,measured and evaluated their physique level. Results Urine BPA detection rate of children detected was 77.2%,the concentration range was ND ~ 79.52 ng/mL,the median was 1.32 ng/mL,the interquartile range was 0.35~4.01 ng/mL.The urine BPA concentration was significantly higher in girls than boys (Z=-3.687,P<0.01);The urine BPA concentration was significantly higher in 8~11 age group than 6~7 age group (Z=-1.986,P<0.05).The obesity and overweight rate was as high as 32.9%,including the obesity rate-12.9%,the overweight rate-20.1%;and the angular rate was 2.6%.The obesity rate was significantly higher in boys than in girls(χ²=24.935,P<0.01).There was no significant difference between urine BPA concentrations of obese,overweight,angular and normal weight groups (P>0.05). Conclusion Shanghai school-age children are exposed to BPA generally.Severe obesity problem exists among school-age children.

Key words: bisphenol A, obesity, children

摘要： 目的 初步探讨上海市学龄儿童双酚A的暴露现状及其与肥胖的关系。方法 收集500名6~11岁的在校小学生的尿样,采用高效液相色谱法检测其尿液总双酚A浓度,并进行体格测量和评估。结果 被检儿童的尿液双酚A检出率为77.2%,浓度范围ND～79.52 ng/mL,中位数1.32 ng/mL,四分位数间距为0.35~4.01 ng/mL。其中女生尿液双酚A浓度高于男生,差异有统计学意义(Z=-3.687,P<0.01);8~11岁组尿液双酚A浓度高于6~7岁组(Z=-1.986,P<0.05)。肥胖及超重率高达32.9%,其中肥胖率为12.9%,超重率为20.1%,消瘦率为2.6%,男童肥胖率高于女童,差异有统计学意义(χ²=24.935,P<0.01)。肥胖组、超重组、消瘦组与正常体重组之间尿液双酚A浓度差异均无统计学意义(P>0.05)。结论 上海市学龄儿童普遍存在双酚A暴露;学龄儿童存在严重的肥胖问题。

关键词: 双酚A, 肥胖, 儿童