Abstract: Objective To investigate the association of serum levels of vitamin A, D and E with recurrent respiratory tract infections(RRTIs). Methods Children aged 6 months-15 years in People′s Hospital of Guangxi Zhuang Autonomous Region were enrolled to finish a face-to-face survey from January to December 2017. Totally 171 children with RRTIs were selected as the RRTI group, whereas 156 health children were used as control group. Blood samples were collected, and high performance liquid chromatography (HPLC) was used to measure serum levels of vitamin A and E. The serum level of 25(OH)D₃ was tested by chemiluminescence. The differences on serum levels of vitamin A, D, E were analyzed between RRTI group and control group. Results The average levels of vitamin A[(0.30±0.06) mg/L vs.(0.39±0.07) mg/L], vitamin D₃ [(72.41±25.59) nmol/L vs.(84.84±29.96) nmol/L] and vitamin E [(8.90±2.32) mg/L vs. (9.72±2.61)mg/L] in RRTI group were significantly lower than those in control group(P＜0.01).The deficiency and insufficiency rate of vitamin A、D₃, and vitamin E insufficiency rate in RRTI group were significantly higher than those in normal control group (P<0.05). Logistic regression analysis showed that vitamin A level lower than 0.3 mg/L (OR=19.225,95%CI: 9.136-40.453) and vitamin D₃ level lower than 50 nmol/L(OR=2.891,95%CI:1.186-7.044) increased the risk of RRTIs in children. Conclusion The insufficiency of vitamin A and D₃ may be critically associated with RRTIs of children.

Key words: respiratory infection, vitamin A, vitamin D, vitamin E, children

摘要： 目的 分析儿童反复呼吸道感染(RRTI)与患儿血清维生素A、D、E水平的相关性,为临床防治提供理论依据。方法 2017年1-12月采集在广西壮族自治区人民医院儿科就诊的6个月~15岁儿童资料,选取171例RRTI儿童为RRTI组,156例为正常对照组。采用高效液相色谱法测定两组儿童血清维生素A和E水平,采用化学发光法检测血清维生素D₃水平。比较RRTI组和正常对照组维生素A、D₃、E水平的差异。结果 RRTI组平均血清维生素A水平为(0.30±0.06)mg/L,维生素D₃水平为(72.41±25.59)nmol/L,维生素E水平为(8.90±2.32)mg/L,均低于正常组的(0.39±0.07)mg/L、(84.84±29.96)nmol/L和(9.72±2.61)mg/L,差异均有统计学意义(P<0.01)。维生素A、D₃缺乏率和不足率、维生素E的不足率在RRTI组均高于正常对照组,差异有统计学意义(P<0.05)。Logistic回归分析提示维生素A水平低(<0.3 mg/L)(OR=19.225,95%CI:9.136~40.453)和维生素D₃缺乏(<50 nmol/L)(OR=2.891,95%CI:1.186~7.044)使得儿童患RRTI的风险增高。结论 维生素A和维生素D₃的亚临床水平缺乏可能与儿童RRTI相关,及时给予补充有助于儿童RRTI的防治。

关键词: 呼吸道感染, 维生素A, 维生素D, 维生素E, 儿童