Research progress on the roles of vitamin A and vitamin D in the adjuvant treatment of children with pneumonia

doi:10.11852/zgetbjzz2018-1035

journal1 ›› 2019, Vol. 27 ›› Issue (2): 164-167.DOI: 10.11852/zgetbjzz2018-1035

Previous Articles Next Articles

Research progress on the roles of vitamin A and vitamin D in the adjuvant treatment of children with pneumonia

WANG Shan-shan¹, GU Lian-jie^1,2, LIU Hong², ZHENG Min³,SONG Jia-le^1,4,5

1 Departemnt of Pediatrics, the Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541100, China;
2 Department of Neonate,Guangdong Maternal and Child Health Care Hospital, Guangzhou,Guangdong 510010, China;
3 Department of Laboratory Medicine,Obstetrics and Gynecology Hospital,Children′s Hospital Affiliated to Guangxi University of Science and Technology, Liuzhou,Guangxi 545001, China;
4 School of Public Health, Guilin Medical University, Guilin, Guangxi 541100, China;
5 Guangxi Colleges and University Key Laboratory of Preventive Medicine, Guilin,Guangxi 541100, China

Online:2019-02-20 Published:2019-02-20
Contact: SONG Jia-le, E-mail:songjiale@glmc.edu.cn

维生素A与维生素D辅助治疗儿童肺炎的研究进展

王珊珊¹,顾廉洁^1,2,刘鸿²,郑敏³,宋家乐^1,4,5

1 桂林医学院附属医院儿科,广西桂林 541100;
2 广东省妇幼保健院儿科,广东广州 510000;
3 广西科技大学附属柳州市儿童医院暨柳州市妇幼保健院儿童保健部,广西柳州 545001;
4 桂林医学院公共卫生学院,广西桂林 541100;
5 广西高校预防医学重点实验室,广西桂林 541100

作者简介:王珊珊(1990-),女,在读硕士研究生,主要研究方向为少儿卫生保健与新生儿呼吸系统疾病
基金资助:
广西省自然科学基金(2017GXNSFAA198312); 广西教育厅广西高等学校千名中青年骨干教师培育计划资助(2018-18)

Abstract

Abstract: Pneumonia is a common infectious disease in children.Its main pathogens are viruses, bacteria, chlamydia and mycoplasma, which seriously affect children′s health.Antibiotics are mainly used in clinical treatment, but a variety of drug-resistant strains have appeared in the application of broad-spectrum antibiotics in recent years, resulting in poor treatment efficacy.With the deepening of clinical and basic medical research, vitamin A(Vit A) and vitamin D(Vit D) play an important role in improving the body′s immunity.Therefore, this paper reviews the roles of Vit A and Vit D in the adjuvant treatment of children′s pneumonia and related research progress.

Key words: pneumonia, vitamin A, vitamin D, children

摘要： 肺炎是儿童常见的感染性疾病,其主要病原为病毒、细菌、衣原体和支原体,严重影响儿童的健康。临床以抗生素治疗为主,但近年广谱抗生素的应用出现多种耐药菌株,导致治疗效果欠佳。随着临床及基础医学研究的深入,维生素A(Vit A)和维生素D(Vit D)在提高机体免疫方面起着较为重要的作用。因此,本文就Vit A和Vit D在辅助治疗儿童肺炎中所起到的作用及相关研究进展作一综述。

关键词: 肺炎, 维生素A, 维生素D, 儿童

CLC Number:

R725.6

WANG Shan-shan, GU Lian-jie, LIU Hong, ZHENG Min,SONG Jia-le. Research progress on the roles of vitamin A and vitamin D in the adjuvant treatment of children with pneumonia[J]. journal1, 2019, 27(2): 164-167.

王珊珊,顾廉洁,刘鸿,郑敏,宋家乐. 维生素A与维生素D辅助治疗儿童肺炎的研究进展[J]. 中国儿童保健杂志, 2019, 27(2): 164-167.

References

[1] Rudan I, O′Brien KL, Nair H, et al.Epidemiology and etiology of childhood pneumonia in 2010:estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries[J]. J Glob Health,2013,3(1):010401.
[2] 李丽梅, 李伟英.5岁以下儿童维生素A亚临床缺乏与贫血和呼吸道感染的关系及预防措施[J]. 临床和实验医学杂志,2014,13(22):1889-1891.
[3] Inamo Y, Hasegawa M, Saito K, et al.Serum vitamin D concentrations and associated severity of acute lower respiratory tract infections in Japanese hospitalized children[J]. Pediatr Int,2011,53(2):199-201.
[4] Bowden SA, Robinson RF, Carr R, et al.Prevalence of vitamin D deficiency and insufficiency in children withosteopenia or osteoporosis referred to a pediatric metabolic bone clinic[J]. Pediatrics,2008,121(6):1585-90.
[5] 张宇, 刘小兵, 杨丽琛,等.2010—2012年中国6~17岁城市儿童维生素A营养状况[J]. 中华预防医学杂志,2017,51(2):117-120.
[6] 丁媛慧, 孙中厚, 张海美,等.儿童边缘型维生素A缺乏与呼吸道感染相关性及危险因素分析[J]. 中国儿童保健杂志,2016,24(4):393-395.
[7] 王军陵, 叶静萍.维生素A在小儿肺炎治疗中的作用机制和疗效[J]. 临床合理用药杂志,2018,11(3):172-173.
[8] Xiang XS, Zhao YZ, Li N, et al.Accumulation of DC in laminapropria induced by FMS-like tyrosine kinase 3 ligand aggravates the intestinal inflammatory response during endotoxemia[J]. Inflammation,2010,33(1):34-45.
[9] Sirisinha S.The pleiotropic role of vitamin A in regulating mucosal immunity.[J]. Asian Pac J Allergy Immunol,2015,33(2):71-89.
[10] 吴立成.小剂量维生素A佐治新生儿感染性肺炎疗效观察[J].中国社区医师,2014,9(34):55.
[11] 李莉, 薛继红, 任华.肺炎患儿治疗前后血清维生素A营养状况及铁含量的变化[J]. 中国儿童保健杂志,2015,23(10):1111-1113.
[12] Amaral CT, Ms NNP, Maciel BLL, et al.Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection[J]. Pediatric Pulmonology,2013,48(5):481-489.
[13] Kartasurya MI, Ahmed F, Subagio HW, et al.Zinc combined with vitamin A reduces upper respiratory tract infection morbidity in a randomised trial in preschool children in Indonesia[J]. Br J Nutr,2012,108(12):2251-2260.
[14] Humphrey JH,Ichord RN.Safety of vitamin A supplementation of postpartum women and young children[J]. Food & Nutrition Bulletin,2011,22(22):311-319.
[15] Hathcock JN.Vitamin and mineral safety [M].2nd ed.Washington DC:Council for Responsible Nutrition Press.2004:85-91.
[16] Binkley N, Ramamurthy R, Krueger D.Low vitamin D status:definition, prevalence, consequences, and correction[J]. Endocrinol Metab Clin Nortb Am,2010,38(1):287-301.
[17] Zhao Y, Yu B, Mao X, et al.Dietary vitamin D supplementation attenuates immune responses of pigs challenged with rotavirus potentially through the retinoic acid-inducible gene I signalling pathway[J]. Br J Nutr,2014,112(3):381.
[18] 喻文, 罗红敏.维生素D₃对脓毒症患者维生素D和抗菌肽水平的影响:一项随机安慰剂对照试验[J]. 中华危重病急救医学,2016,28(2):98.
[19] 李欣, 岳冬辉, 毕岩.呼吸道黏膜固有免疫抗流感病毒研究[J]. 中医药临床杂志,2017,29(6):759-761.
[20] Liu K,Nussenzweig MC.Origin and development of dendritic cells[J]. Immunol Rev,2010,234(1):45-54.
[21] Jin CJ, Hong CY, Takei M, et al.All-trans retinoic acid inhibits the differentiation, maturation, and function of human monocyte-derived dendritic cells[J]. Leukemia Research,2010,34(4):513.
[22] 中华医学会儿科学分会呼吸学组.儿童社区获得性肺炎管理指南(2013修订)(上)[J]. 中华儿科杂志,2013,51(10):745-752.
[23] 李敏, 彭雁忠, 熊晓佳.维生素D与免疫[J]. 国际免疫学杂志,2014,37(5):403-407.
[24] Chen S, Sims GP, Chen XX, et al.Modulatory effects of 1,25-Dihydroxyvitamin D₃ on human B cell differentiation[J]. J Immunol,2007,179(3):1634-1647.
[25] 丁玲, 李温慈, 张宇.维生素D辅治婴幼儿肺炎疗效观察[J]. 浙江中西医结合杂志,2016,26(12):1107-1109.
[26] Leis KS, Mcnally JD, Montgomery MR.急性下呼吸道感染儿童的维生素D摄入[J]. 中国当代儿科杂志,2012,14(1):1-6.
[27] 钱婧, 袁艺.血清25-(OH)D₃水平与儿童社区获得性肺炎严重程度及免疫功能相关性研究[J]. 中国儿童保健杂志,2018,26(8):827-830.
[28] 朱庆龄, 盛晓阳.维生素D过量及中毒的研究进展[J]. 中华儿科杂志,2015,53(3):235-237.
[29] Casey CF,Slawson DC.Vitamin D supplementation in infants, children, and adolescents[J].Am Fam Physician,2010,81(81):745-748.

Research progress on the roles of vitamin A and vitamin D in the adjuvant treatment of children with pneumonia

维生素A与维生素D辅助治疗儿童肺炎的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	XIANG Wei. Early prevention of dyslipidemia in children and adolescents as well as cardiovascular health in adulthood [J]. Chinese Journal of Child Health Care, 2023, 31(7): 697-702.
[2]	WU Ting, LI Fei. Adverse factors in early life and the development and prevention of chronic diseases [J]. Chinese Journal of Child Health Care, 2023, 31(7): 703-706.
[3]	LIU Haodong, LI Cheng, ZHAO Min, XI Bo. Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children [J]. Chinese Journal of Child Health Care, 2023, 31(7): 707-712.
[4]	LIU Min, ZHANG Qian, YANG Ting, CHEN Jie, CHEN Li, DAI Ying, JIA Feiyong, WU Lijie, HAO Yan, LI Ling, ZHANG Jie, KE Xiaoyan, YI Mingji, HONG Qi, CHEN Jinjin, FANG Shuanfeng, WANG Yichao, WANG Qi, JIN Chunhua, LI Tingyu. Multi-center survey on serum folic acid in preschool children in China [J]. Chinese Journal of Child Health Care, 2023, 31(7): 713-717.
[5]	HUO Yanyan, LIU Zhongling, MA Ling, WU Dan, WANG Xiulian, QIU Xiaoyan, DOU Jiaying, REN Yuqian, LI Yicheng, HONG Xia, CHEN Jinjin. Status quo and risk factors for different body proportions of children under 2 years old in the real world [J]. Chinese Journal of Child Health Care, 2023, 31(7): 718-723.
[6]	LIU Huijuan, SONG Zhixiao, GAO Nannan, ZHANG Li, SUN Jin, QIAO Xiuyun, KE Jiamei, LI Yan. Status quo and related factors of Chinese vocabulary and grammar development in children aged 2 to 6 years [J]. Chinese Journal of Child Health Care, 2023, 31(7): 724-730.
[7]	LI Rong, LI Nian, WU Dandan, HUANG Rong, CHEN Yinhua. Effect of methylphenidate hydrochloride prolonged-release tablets on the growth of children with attention deficit hyperactivity disorder [J]. Chinese Journal of Child Health Care, 2023, 31(7): 731-735.
[8]	ZHANG Chao. Application of early start Denver model in the rehabilitation of children with autism spectrum disorder of different conditions [J]. Chinese Journal of Child Health Care, 2023, 31(7): 736-740.
[9]	YANG Yuru, WANG Hong, XU Shuhong, CAO Yanmei, MENG Xian, GE Dongmei. Association between bone development and vitamin K in children aged 0 to 14 years [J]. Chinese Journal of Child Health Care, 2023, 31(7): 746-750.
[10]	YE Zhixu, YU Fuxun. Research progress of gut microbiota and respiratory virus infection in children [J]. Chinese Journal of Child Health Care, 2023, 31(7): 766-769.
[11]	LI Weiwei, ZHANG Dandan, LIU Xiaoming, CHEN Jiao, XIA Lu. Application of long-term management mode based on Internet technology in children with intractable epilepsy [J]. Chinese Journal of Child Health Care, 2023, 31(7): 781-784.
[12]	ZHU Lijun, LI Biaozhang, ZHOU Jiawen, WU Baixin, LI Weidong. Disease burden of low body weight in children under 5 years old in China from 1990 to 2019 [J]. Chinese Journal of Child Health Care, 2023, 31(7): 790-793.
[13]	CAO Yachuan, DOU Jijuan, MA Yaping, REN Jindong, CHEN Xinyan. Correlation of lipid metabolism with left ventricular hypertrophy and left ventricular remodeling in obese children [J]. Chinese Journal of Child Health Care, 2023, 31(7): 809-812.
[14]	LI Xiuhong. Early identification of Chinese developmental dyslexia should be valued [J]. Chinese Journal of Child Health Care, 2023, 31(6): 586-589.
[15]	WANG Hongan, YU Dongchuan, LIU Fulin, CHI Xia. Feasibility study on rapid screening of learning disabilities by number cancellation test in combination with machine learning algorithm [J]. Chinese Journal of Child Health Care, 2023, 31(6): 595-600.