Abstract: Objective To detect serum levels of 25-(OH)D,calcium (Ca),phosphorus (P) and parathyroid hormone (PTH) in children with mild rotavirus enteritis and benign convulsions,in order to provide reference for clinical vitamin D supplementation. Methods A total of 58 cases of children aged 6 months to 2 years,who were with mild rotavirus enteritis and benign convulsions in Jiangmen Central Hospital from October to March in the following year from 2015 to 2018,were selected into case group.And 62 healthy children at the same time were selected as control group.Serum 25-(OH) D,calcium,phosphorus,PTH level and fecal rotavirus were tested in the two groups. Results 1)In all subjects,most serum 25-(OH)D concentrations were insufficient or deficient,only few were sufficient.2) Serum calcium and 25-(OH)D concentration in case group was significantly lower than those in control group (P<0.05),while the differences on serum P and PTH concentrations between the two groups were not significant (P>0.05).3) Serum 25-(OH)D concentration was negatively correlated with PTH concentration in case group and control group (r=-0.324,-0.264,P<0.05). Conclusion The serum level of 25-(OH) D in children in Jiangmen city is generally insufficient or deficient.And the low levels of serum Ca and 25-(OH)D may be the potentially risk factors for mild rotavirus enteritis and benign convulsions.The level of serum 25-(OH)D in the case group was lower than that in the control group.

Key words: mild rotavirus enteritis, benign convulsions, children, vitamin D, calcium, phosphorus, parathyroid hormone

摘要： 目的 检测轻度轮状病毒肠炎伴良性惊厥患儿血清25-(OH)D、钙(Ca)、磷(P)、甲状旁腺激素(PTH)水平,为临床补充维生素D提供参考。方法 选取2015-2018年每年10月-次年3月在江门市中心医院就诊的6月~2岁轻度轮状病毒肠炎伴良性惊厥患儿58例为病例组,同期该年龄段健康儿童62例为对照组,检测血清25-(OH)D、Ca、P、PTH水平及大便轮状病毒。结果 1)所有纳入对象中,多数血清25-(OH)D浓度处于不足或缺乏状态,极少数充足。2)病例组血清Ca、25-(OH)D浓度均低于对照组,差异有统计学意义(P<0.05);两组血清P及PTH浓度比较差异无统计学意义(P>0.05)。3)病例组和对照组血清25-(OH)D浓度和PTH浓度均呈负相关(r=-0.324、-0.264,P<0.05)。结论 江门市儿童血清25-(OH)D水平普遍不足或缺乏,儿童血钙、25-(OH)D含量低可能是轮状病毒肠炎伴惊厥发作的潜在危险因素。

关键词: 轻度轮状病毒肠炎, 良性惊厥, 儿童, 维生素D, 钙, 磷, 甲状旁腺激素