Sleep problems and recent advances in children with epilepsy

doi:10.11852/zgetbjzz2019-0341

Abstract

Abstract: Sleep problems are common behavioral problems in child health care,especially in children with epilepsy. Sleep problems or sleep disorders,such as difficulty in falling asleep,waking up at night,obstructive sleep apnea,sleepwalking and nightmares,often lead to impaired daytime function in children and families. However,children with epilepsy are more likely to have sleep problems because abnormal brain electrical activity during sleep disturbs the normal sleep structure.Sleep and epilepsy interact with each other and have complex interactions. Sleep can activate epileptiform discharge,and seizures will interfere with sleep structure. In addition,sleep problems also affect the cognition,behavior and quality of life in children with epilepsy. This article mainly discusses sleep and sleep related problems in children with epilepsy,and summarizes the epidemiology of sleep problems in children with epilepsy,the relationship between sleep problems and epilepsy,the influence of sleep on cognitive function of children with epilepsy,and sleep intervention.

Key words: sleep, epilepsy, children

摘要： 睡眠问题是儿童保健中常见的行为问题,在癫痫儿童中更为常见。睡眠问题或睡眠障碍表现为入睡困难、夜醒、阻塞性睡眠呼吸暂停、梦游及梦魇等,常导致儿童及家庭的日间功能受损;而癫痫儿童由于睡眠中异常脑电活动扰乱了正常睡眠结构,更容易萌生睡眠问题。睡眠与癫痫之间互相影响,有复杂的相互作用,睡眠能激活癫痫样放电,癫痫发作会干扰睡眠结构;另外,睡眠问题也对癫痫儿童的认知、行为与生活质量等多方面造成影响。本文主要讨论癫痫儿童的睡眠及睡眠相关问题,对癫痫儿童中睡眠问题的流行病学、睡眠问题与癫痫之间的关系、睡眠对癫痫儿童认知功能的影响以及睡眠干预进行综述。

关键词: 睡眠, 癫痫, 儿童

CLC Number:

R742.1

ZHANG Gui-rong, SHAO Jie. Sleep problems and recent advances in children with epilepsy[J]. journal1, 2020, 28(3): 295-298.

张桂榕, 邵洁. 癫痫儿童的睡眠问题及研究进展[J]. 中国儿童保健杂志, 2020, 28(3): 295-298.

References

[1] Carter KA,Hathaway NE,Lettieri CF.Common sleep disorders in children[J].Am Fam Physician,2014,89(5):368-377.
[2] Liu X,Liu L,Owens JA,et al.Sleep patterns and sleep problems among school children in the United States and China[J].Pediatrics,2005,115(Suppl 1):241-249.
[3] Takahashi M,Adachi M,Yasuda S,et al.Prevalence of sleep problems in Japanese preschoolers in a medium-sized city:community-based survey using the Children′s Sleep Habits Questionnaire[J].Pediatr Int,2017,59(6):747-750.
[4] Wang G,Xu G,Lu N,et al.Sleep disutbances and emotional/behavioral problems among Chinese school-aged children:prevalence and association[J].Sleep Med,2013,14:e301.
[5] Owens JA,Spirito A,McGuinn M,et al.Sleep habits and sleep disturbance in elementary school-aged children[J].J Dev Behav Pediatr,2000,21(1):27-36.
[6] Surani S,Hesselbacher S,Surani S,et al.Sleep habits of elementary and middle school children in South Texas[J].Sleep Disord,2015.doi:10.1155/2015/179103.
[7] Larson AM,Ryther RCC,Jennesson M,et al.Impact of pediatric epilepsy on sleep patterns and behaviors in children and parents[J].Epilepsia,2012,53(7):1162-1169.
[8] Joaquim P,Menezes O,Sudbrack P,et al.Insomnia in people with epilepsy:a review of insomnia prevalence,risk factors and associations with epilepsy-related factors[J].Epilepsy Res,2017,135(5):158-167.
[9] Giorelli AS,Passos P,Carnaval T,et al.Excessive daytime sleepiness and epilepsy:a systematic review[J].Epilepsy Res Treat,2013.doi:10.1155/2013/629469.
[10] Cohen R,Halevy A,Shuper A.Children′s sleep disturbance scale in differentiating neurological disorders[J].Pediatr Neurol,2013,49(6):465-468.
[11] Reilly C,Atkinson P,Memon A,et al.Child and parental sleep in young children with epilepsy:a population-based case-control study[J].Epilepsia Open,2018,3(3):383-391.
[12] 中华医学会.临床诊疗指南-癫痫病分册[M].2版.北京:人民卫生出版社,2015.
[13] Chokroverty S.Sleep disorders medicine[M].NY:Springer New York,2017.
[14] Klobucnikova K,Carnicka Z,Wagnerova H,et al.Is nocturnal epilepsy cause of disturbed quality of sleep and elevated daytime sleepiness?[J].Neuro Endocrinol Lett,2014,35(5):405-410.
[15] Samaitiené R,Norkūniené J,Tumienē B,et al.Sleep and behavioral problems in rolandic epilepsy[J].Pediatr Neurol,2013,48(2):115-122.
[16] Batista BHB,Nunes ML.Evaluation of sleep habits in children with epilepsy[J].Epilepsy Behav,2007,11(1):60-64.
[17] Beattie JF,Koch SA,BoldenL B,et al.Neuropsychological consequences of sleep disturbance in children with epilepsy[J].Epilepsy Behav,2016,57(Pt A):118-123.
[18] Beghi M,Beghi E,Cornaggia CM,et al.Idiopathic generalized epilepsies of adolescence[J].Epilepsia,2006,47 (Suppl 2):107-110.
[19] Miano S,Tabarrini A,Vitelli O,et al.The cooccurrence of interictal discharges and seizures in pediatric sleep-disordered breathing[J].Epilepsy Behav,2013,29(3):508-512.
[20] Segal E,Vendrame M,Gregas M,et al.Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy[J].Pediatr Neurol,2012,46(6):359-362.
[21] Nayak C,Sinha S,Ramachandraiah CT,et al.Differential im provement of the sleep quality among patients with juvenile myoclonic epilepsy with valproic acid:a longitudinal sleep questionnaire-based study[J].Ann Indian Acad Neurol,2015,18(4):403-407.
[22] Klobucnikova K,Kollar B,Martiniskova Z.Daytime sleepiness and changes of sleep architecture in patients with epilepsy[J].Neuro Endocrinol Lett,2009,30(5):599-603.
[23] Elkhayat HA,Hassanein SM,Tomoum HY,et al.Melatonin and sleep-related problems in children with intractable epilepsy[J].Pediatr Neurol,2010,42(4):249-254.
[24] Jain SV,Horn PS,Simakajornboon N,et al.Melatonin improves sleep in children with epilepsy:a randomized,double-blind,crossover study[J].Sleep Med,2015,16(5):637-644.
[25] Brigo F,Igwe SC,DelFelice A.Melatonin as add-on treatment for epilepsy[J].Cochrane Database Syst Rev,2016(8):CD006967.
[26] Reilly C,Atkinson P,Das KB,et al.Cognition in school-aged children with “active” epilepsy:a population-based study[J].J Clin Exp Neuropsychol,2015,37(4):429-438.
[27] Chin RFM,Cumberland PM,Pujar SS,et al.Outcomes of childhood epilepsy at age 33 years:a population-based birth-cohort study[J].Epilepsia,2011,52(8):1513-1521.
[28] Galer S,Urbain C,DeTiège X,et al.Impaired sleep-related consolidation of declarative memories in idiopathic focal epilepsies of childhood[J].Epilepsy Behav,2015,43:16-23.
[29] Parisi P,Moavero R,Verrotti A,et al.Attention deficit hyperactivity disorder in children with epilepsy[J].Brain Dev,2010,32(1):10-16.
[30] Holley S,Whitney A,Kirkham FJ,et al.Executive function and sleep problems in childhood epilepsy[J].Epilepsy Behav,2014,37:20-25.
[31] Becker DA,Fennell EB,Carney PR.Daytime behavior and sleep disturbance in childhood epilepsy[J].Epilepsy Behav,2004,5(5):708-715.
[32] Malow BA.Sleep disorders,epilepsy,and autism[J].Ment Retard Dev Disabil Res Rev,2004,10(2):122-125.