Abstract: Objective To investigate the associations between febrile seizures and frequent nocturnal enuresis, so as to provide evidence for study of risk factors for enuresis and explore the changes of the associations in different ages and genders. Methods A stratified cluster random sampling method was used to select 85 860 children aged 5 to 12 years in 3 urban areas and 4 suburbs in Shanghai from June 2014 to June 2015, and children were asked to fill out questionnaire. Multivariate Logistic regression analysis was used to analyze the association between febrile seizures and frequent nocturnal enuresis. Sensitivity analysis was performed to observe the changes of association in ages and genders. Results Finally 62 290 valid questionnaires were enrolled in this study. Multivariate analysis showed that children with febrile seizures still had a high risk of enuresis after controlling for confounding factors (OR=7.740, 95%CI:5.512 - 10.870, P<0.001). In addition, the association between the two increased with ages (P<0.001), which was more significant in girls (OR=13.798, 95%CI:8.056 - 23.631, P<0.001) than boys (OR=4.422, 95%CI:2.580 - 7.579, P<0.001). Conclusion Febrile seizures is significantly associated with frequent nocturnal enuresis, especially in older age groups and girls, suggesting that FS is one of the risk factors for frequent nocturnal enuresis.

Key words: frequent nocturnal enuresis, febrile seizures, children, risk factors, gender

摘要： 目的 探讨儿童热性惊厥与频繁夜间遗尿症的关系,为遗尿症的危险因素提供研究依据,并分析在儿童不同年龄及性别中二者相关性的变化。方法 用分层整群随机抽样的方法于2014年6月—2015年6月在上海市抽取3个市区和4个郊区,以5~12岁儿童为研究对象并分发问卷85 860份,采用多因素Logistic回归分析热性惊厥与频繁夜间遗尿症的关系,敏感性分析观察二者相关性在年龄和性别中的变化。结果 上海市共有62 290名5~12岁儿童纳入研究。控制混杂因素后,多因素分析显示热性惊厥儿童患频繁夜间遗尿症的风险较高(OR=7.740,95%CI:5.512~10.870,P<0.001)。随着儿童年龄增加二者相关性越强(P<0.001),尤其在女童中(OR=13.798,95%CI:8.056~23.631,P<0.001)比男童(OR=4.422,95%CI:2.580~7.579,P<0.001)更为显著。结论 热性惊厥与频繁夜间遗尿症显著相关,尤其在高年龄组与女童中更为显著,提示热性惊厥为频繁夜间遗尿症的危险因素之一。

关键词: 频繁夜间遗尿症, 热性惊厥, 儿童, 危险因素, 性别