Abstract: Objective To collect information on nutrition of vitamin D in Xuzhou children aged 0~5 in winter,and to instruct parents how to properly use vitamin D. Method The serum samples were collected from 242 cases at the age of 0~5 who received conventional healthcare in the outpatient of children healthcare at the Xuzhou Maternial and Child Health Care Hospital,and the serum levels of 25-hydroxy vitaminD [25(OH)D]were determined using immunochromatography. Results The mean level of 25(OH)D was (51.34±19.38) nmol/L in these 242 cases aged 0~5.108 cases,accounting for 44.63% of them,exhibited adequate levels of 25(OH)D,while 55.37% of them showed low levels of 25(OH)D (deficient in 26.45%,scarce in 28.93%).There was no significant difference in the level of 25(OH)D between girls and boys at the age of 0~5 (P>0.05).Children at the age of 3~5 had significantly lower level of 25(OH)D compared to those less than 1 year old (P<0.05). Conclusions In Xuzhou City,children at the age of 0~5 years old generally exhibited low levels of 25(OH)D.Therefore,attention should be paid to the 25(OH)D test and supplementation.

Key words: 25-hydroxyvitamin D, serum concentration, immunochromatography, children, winter

摘要： 目的 了解徐州市区冬季0～5岁儿童的维生素D营养状况,指导临床及家长合理使用维生素D。方法 收集2015年12月-2016年2月在徐州市妇幼保健院儿保科门诊进行常规保健的242例0～5岁儿童血清,采用免疫层析法检测血清25-羟基维生素D[25-(OH)VD]。结果 242 例0～5岁儿童血清25-(OH)VD的平均水平为(51.34±19.38)nmol/L,其中充足组108例,占44.63%,有55.37%的儿童25-(OH)VD处于较低水平(26.45%不足、28.93%缺乏)。0～5岁儿童血清25-(OH)VD水平在不同性别间差异无统计学意义(P＞0.05);3～5岁组儿童血清25-(OH)VD水平明显低于＜1岁组,差异有统计学意义(P＜0.05)。结论 徐州市区0～5岁儿童血清25－(OH)VD水平普遍偏低,应重视儿童血清25-(OH)VD的检测及补充。

关键词: 25羟基维生素D, 血清浓度, 免疫层析, 儿童, 冬季