Research progress on the association of phthalates with children attention deficit  hyperactivity disorder

doi:10.11852/zgetbjzz2018-26-05-15

Abstract

Abstract: With the increasing deterioration of environment problems, the impact of environmental toxicants on the development of children′s neuropsychological behavior has become a hot social issue. Attention deficit hyperactivity disorder (ADHD) is one of the most common mental and behavioral disorders in childhood, and environmental toxicants may contribute to child ADHD symptoms and disease. Increasing toxicological and epidemiological evidence suggests that there may be associations between phthalates (PAEs) and children′s ADHD symptoms and disease. The potential mechanisms may involve dopamine neuronal, thyroid system, oxidative stress and testosterone modification abnormalities. It is essential to understand the correlation and potential mechanisms between PAEs and ADHD in children for further etiology and pathogenesis study.

Key words: attention deficit hyperactivity disorder, Phthalates, children

摘要： 随着环境问题日益严重,环境污染物对儿童神经心理行为发育的影响成为社会关注的热点问题。注意缺陷多动障碍(ADHD)是儿童期最普遍、最常见的心理与行为障碍之一,环境毒物对于儿童ADHD症状、疾病存在一定的贡献。越来越多的毒理学和流行病学证据表明,邻苯二甲酸酯(PAEs)与儿童ADHD症状、疾病可能存在关联,二者间的关联可能涉及到多巴胺神经元系统、甲状腺系统、氧化应激及睾酮修饰的异常。明确PAEs与儿童ADHD的关联及内在机制,对于深入探索ADHD病因学和病理机制至关重要。

关键词: 注意缺陷多动障碍, 邻苯二甲酸酯, 儿童

CLC Number:

R179

HU Dan, HE Hui-min, SUN Jin, XIAO Xu-wu. Research progress on the association of phthalates with children attention deficit hyperactivity disorder[J]. journal1, 2018, 26(5): 518-520.

胡丹, 何绘敏, 孙瑾, 肖绪武. 邻苯二甲酸酯与儿童注意缺陷多动障碍关联的研究进展[J]. 中国儿童保健杂志, 2018, 26(5): 518-520.

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Research progress on the association of phthalates with children attention deficit hyperactivity disorder

邻苯二甲酸酯与儿童注意缺陷多动障碍关联的研究进展

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