Abstract: Objective To describe the status of food hypersensitivity in children with tourette syndrome(TS) by food intolerance test, and to analyze the relationship between food intolerance and TS. Methods Retrospective analysis was used to enroll 61 TS patients from January 2016 to October 2017, including 39 boys and 22 girls. And 50 healthy children over four years old were enrolled in control group, including 28 boys and 22 girls. The enzyme linked immunosorbent assay(ELISA) method was applied to detect the serum specific antibodies IgG levels of 14 kinds of food allergens in the two group of children, and the differences were compared. Results The food intolerance rate was 98.4%(60/61) in TS children, while 78.0%(39/50) in healthy children. And the difference on food intolerance rate between the two groups was significant(P＜0.01). The rates of multiple kinds of food intolerance in TS children were significantly higher than those in healthy children (one type of food intolerance:23.0% vs. 34.0%;two types of food intolerance:24.6% vs. 38.0%;three types of food intolerance:34.4% vs. 6.0%;four types of food intolerance:16.4% vs. 0%,all P＜0.01). Eggs and milk were the main types of food intolerances in two groups, but the intolerance in TS children was more serious than that in the healthy children (IgG+++:36.7% vs.19.7%, P＜0.001). Conclusion Food intolerance test is a useful method for TS children to find food allergens, thereby providing guidance for children′s diet in order to promote children′s healthy development.

Key words: food intolerance, tourette syndrome, children

摘要： 目的 对抽动症患儿进行食物不耐受检测,了解患儿食物过敏情况,并分析食物不耐受与抽动症的相关性。方法 采用回顾性分析的方法,收集 2016年1月-2017年10月于武汉大学人民医院小儿神经科门诊及病房就诊的符合条件的抽动症患儿61例,其中男39例,女22例,对照组为在武汉大学人民医院体检的4岁以上的无抽动障碍的儿童50例,其中男28例,女22例。采用ELISA半定量间接法检测两组儿童血清中14种食物过敏原的特异性抗体IgG,并做对比分析。结果 对两组儿童进行食物不耐受检测,61例抽动症患儿中60例结果阳性,阳性率达98.4％;50例健康儿童中39例结果阳性,阳性率78.0 %,差异有统计学意义(P＜0.01)。抽动症患儿对多种食物不耐受的程度较健康儿童高(1种食物不耐受:23.0%vs.34.0%;2种:24.6%vs.38.0%;3种:34.4%vs.6.0%;4种:16.4%vs.0%,P＜0.01)。两组儿童不耐受的食物主要是鸡蛋和牛奶,但抽动症患儿不耐受的程度较健康儿童组严重(即IgG为+++: 36.7% vs. 19.7%,P＜0.001)。 结论 食物不耐受检测可作为抽动症患儿寻找食物过敏原的一个有效途径,并可指导抽动症患儿的饮食,促进儿童健康成长。

关键词: 儿童, 食物不耐受, 抽动症