Clinical research on the treatment of autism spectrum disorder children by nasal spray oxytocin

doi:10.11852/zgetbjzz2018-0779

Abstract

Abstract: Objective To explore the role of nasal spray oxytocin therapy for the social interaction of children with autism spectrum disorder (ASD),in order to find new approaches for the treatment of ASD children. Methods A prospective case-control study was conducted. Totally 25 ASD children were enrolled in this study and were randomly divided into treatment group (n=12) and control group (n=13).The treatment group was treated with nasal spray oxytocin therapy,while the control group only received basic treatment. Results 1) There was no significant difference on serum oxytocin level between treatment group and control group before treatment(t=0.09,P>0.05). The serum oxytocin levels in the treatment group were significantly higher than those in control group in the fourth week during treatment and one month after treatment (t=7.41,6.23,P<0.05). 2) There was no significant difference on Social Responsive Scale (SRS) between treatment group and control group before treatment,while the difference was significant in the fourth week during treatment(t=3.87,P<0.05). However,no significant differences on the score of Chinese Version of Pycho-Educational Profile-3rd edition (CPEP-3) were found before treatment,in the fourth week during treatment and after treatment(P>0.05). Conclusions ASD children in nasal spray oxytocin therapy can improve the oxytocin levels in the blood of ASD children and reduce the scores of social intercourse ability scale. So it is promising in the rehabilitation of children with ASD.

Key words: autistic spectrum disorder, nasal spray oxytocin therapy, social interaction, children

摘要： 目的探讨鼻喷催产素疗法对孤独症谱系障碍(ASD)儿童社会交往能力的促进作用,以寻求儿童ASD的治疗新方法。方法采用前瞻性病例对照研究方法,选取2017年7-12月之间,来就诊的ASD儿童25名,随机分为治疗组(n=12)和对照组(n=13)。对治疗组儿童鼻喷催产素的方法进行治疗;对照组儿童不接受鼻喷催产素治疗。结果 1)催产素水平:治疗前,治疗组与对照组儿童血清催产素水平差异无统计学意义(t=0.09,P>0.05);治疗第4周两组血清催产素水平差异有统计学意义(t=7.41,P＜0.05)。治疗结束后1个月,两组血清催产素水平差异有统计学意义(t=6.23, P＜0.05)。2)行为数据:入组时,治疗组与对照组在社交回应量表(SRS)上的得分差异无统计学意义(t=0.19,P＞0.05);治疗第4周,两组儿童SRS量表得分差异有统计学意义(t=3.87,P＜0.05)。入组时、治疗4周及治疗结束后1个月,两组儿童在《心理教育概况中文版(第三版)》(CPEP3)和儿童孤独症评定量表(CARS)得分上的差异均无统计学意义(P>0.05)。结论对ASD儿童进行鼻喷催产素治疗,能提高其血液中催产素水平,而且能降低其在社交回应量表上的分数。鼻喷催产素疗法在ASD儿童的康复治疗中有较大的应用潜质。

关键词: 社会交往能力, 儿童, 孤独症谱系障碍, 鼻喷催产素治疗

CLC Number:

R749.94

TANG Lin, ZHANG Ya-ru, SHAO Zhi. Clinical research on the treatment of autism spectrum disorder children by nasal spray oxytocin[J]. journal1, 2019, 27(1): 73-76.

唐林 , 张雅如, 邵智. 鼻喷催产素治疗儿童孤独症谱系障碍的临床实证研究[J]. 中国儿童保健杂志, 2019, 27(1): 73-76.

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