Role of vitamin AD in the rehabilitation of children with exercise retardation

doi:10.11852/zgetbjzz2019-1110

Abstract

Abstract: Objective To analyze the role of vitamin AD in rehabilitation treatment of children with motor retardation,to guide the clinicl diagnesis. Methods Totally 90 children with motor retardation were randomly divided into control group(n=30), VD group(n=30) and VAD group(n=30).Vitamin A,25 hydroxyvitamin D and IgA levels were detected before and 3 months after treatment,Infection status during hospitalization was investigated. Peabody Motor Development Rating Scale was used to evaluate gross and fine motor ability, and Gessel(Gesell) Development Scale was used to evaluate single development quotient. Results Before treatment, vitamin A and 25-(OH)D levels were lower in the three groups.After 3 months of treatment, the levels of vitamin A and 25-(OH)D in the control group were lower than those before treatment, while those in the VD group were lower and 25-(OH)D levels were higher than those before treatment.Vitamin A and 25-(OH)D levels were increased in VAD group.During hospitalization, the total infection rate was 50% in control group,33.3% in VD group and 13.3% in VAD group.The scores of gross and fine motor function and the evaluation of Gesell Development Scale were improved in the three groups after treatment.The score of gross and fine motor function and the evaluation of VAD group were significantly better than those of VD group and control group.Conclusion Vitamin AD can enhance the resistance, reduce nosocomial infection and improve the curative effect of rehabilitation in children with motor retardation.

Key words: vitamin AD, exercise retardation, rehabilitation therapy, children

摘要： 目的探讨维生素AD(VAD)在运动发育迟缓患儿康复治疗中的作用,指导临床治疗。方法选取2018年10月-2019年5月在本院康复中心住院的运动发育迟缓患儿90例,随机分为对照组、维生素D(VD)组和VAD组各30例,治疗前、治疗3 个月后完善维生素A、25-(OH)D、IgA检测,调查住院期间感染情况;采用Peabody运动发育评定量表评定粗大、精细运动能力;采用盖塞尔(Gesell)发育量表评估单项发育商。结果治疗前,三组患儿维生素A、25-(OH)D均偏低;治疗3个月后,对照组较前降低,VD组维生素A较前降低、25-(OH)D较前提高,VAD组维生素A、25-(OH)D较前均提高;住院期间对照组总感染率为50%,VD组总感染率为33.3%,VAD总感染率为13.3%;三组患儿治疗后粗大、精细运动功能评分、Gesell发育量表评估较前均有所提高,VAD组明显优于VD组和对照组,差异有统计学意义(P<0.05)。结论对于住院康复治疗的运动发育迟缓患儿,VAD能增强抵抗力,减少康复期间院内感染,提高康复治疗疗效。

关键词: 维生素AD, 运动发育迟缓, 康复治疗, 儿童

CLC Number:

R749

LYU Nan, MA Cai-yun, LI Jing-jie, SHANG Qing. Role of vitamin AD in the rehabilitation of children with exercise retardation[J]. journal1, 2020, 28(6): 676-679.

吕楠, 马彩云, 李靖婕, 尚清. 维生素AD在运动发育迟缓患儿康复治疗中的作用[J]. 中国儿童保健杂志, 2020, 28(6): 676-679.

References

[1] 刘振寰,戴淑凤.儿童运动发育迟缓康复训练图谱[M].北京:北京大学出版社,2017:1-26.
[2] 李明, 武元.运动发育迟缓的早期识别与诊断[J].中国实用儿科杂志,2016,31(10):743-747.
[3] 李微娜,贺媛媛,郝恒瑞,等.血清维生素A、D与不同年龄段儿童反复呼吸道感染的相关性及危险因素分析[J].中国妇幼保健,2018,33(24):5856-5859.
[4] 周崇臣,尚清.婴幼儿运动障碍评估与康复[M].北京:北京大学医学出版社,2017:51-66.
[5] 杨芳,龚建华,万瑞平,等.Peabody粗大运动发育量表与粗大运动功能测试量表在中枢性协调障碍康复评估中的应用[J].中国妇幼保健,2014,29(19):3097-3099.
[6] de CastroMagalhães L, Cardoso AA, Guimarães MAP, et al.How can we make our assessment of motor ability relevant cross-culturally?[J].Curr Dev Disord Rep,2015,2(2):157-164.
[7] Hauser-CramP,Shonkoff JP.Rethinking the assessment of child-focused outcomes:Current issues in theory and policy[M]//Evaluating family programs.London; New York:Routledge,2017:73-94.
[8] Hou N, Ren L, Gong M, et al.Vitamin A deficiency impairs spatial learning and memory:the mechanism of abnormal CBP-dependent histone acetylation regulated by retinoic acid receptor alpha[J].Mol Neurobiol,2015,51(2):633-647.
[9] 杨春.中国人群维生素 A 的影响因素[J].医学综述,2016,22(7):1249-1252.
[10] Deminice TMM, Ferraz IS, Monteiro JP, et al.Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood, human milk, and the umbilical cord[J].J Int Med Res,2018,46(4):1555-1569.
[11] 金春华,王晓燕,张丽丽,等.健康儿童脂溶性维生素 A、D、E现状分析[J].中华临床营养杂志,2016,24(6):349-353.
[12] 李廷玉.维生素A缺乏的诊断、治疗及预防[J].中华实用儿科临床杂志,2013,28(19):1519-1520.
[13] 郑双双,詹建英,朱冰泉,等.中国儿童维生素D营养状况流行病学研究进展[J].中华儿科杂志,2019,57(3):232-234.
[14] Patrick RP, Ames BN.Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2:relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior[J].Faseb J,2015,29(6):2207-2222.
[15] Hu Y, Chen J, Wang R, et al.Vitamin D nutritional status and its related factors for Chinese children and adolescents in 2010-2012[J].Nutrients,2017,9(9):1024.
[16] 全国佝偻病防治科研协作组,中国优生科学协会小儿营养专业委员会.维生素D缺乏及维生素D缺乏性佝偻病防治建议[J].中国儿童保健杂志,2015,23(7):781-782.
[17] 毛春婷, 施圣云, 张阳, 等.2266 例 0~ 16 岁儿童维生素 D 营养状况调查与分析[J].中国儿童保健杂志,2014,22(11):1188-1190.
[18]Bailey RL, WestJr KP, Black RE.The epidemiology of global micronutrient deficiencies[J].Ann Nutr Metab,2015,66(Suppl 2):22-33.
[19] Liu X, Liu J,Xiong X, et al.Correlation between nutrition and symptoms:nutritional survey of children with autism spectrum disorder in Chongqing, China[J].Nutrients,2016,8(5):294.