Abstract: Objective To study on the relationships between serum vitamin A and E levels and thymus (T) cellular immunity in children with recurrent respiratory infection,in order to provide basis for clinical treatment. Methods A total of 60 children with recurrent respiratory infection admitted in Lu'an People's Hospital from March 2016 to August 2019 were enrolled in study group,and 53 healthy children were selected as control group.Serum vitamin A,vitamin E and T cellular immunological indicators of the two groups were detected and compared.Pearson correlation analysis was used to explore the relationship between serum vitamin A,E levels and T cellular immunity of children in the study group. Results The levels of vitamin A,cluster of differentiation (CD) CD3⁺,CD4⁺ and CD4⁺/CD8⁺ in the study group were significantly lower than those in control group,while the CD8⁺ in study group was significantly higher than that in control group (P<0.05).The vitamin E levels in the two groups were similar (P＞0.05).In the study group,the level of vitamin A was positively correlated with CD3⁺,CD4⁺ and CD4⁺/CD8⁺levels(r=0.769,0.814,0.795, P<0.05),and negatively correlated with the CD8⁺levels(r=-0.752,P<0.05).However,vitamin E level was not significantly related to the indexes of T cellular immunology(P＞0.05). Conclusion s There is a close correlation between serum vitamin A and T cell immunity in children with recurrent respiratory tract infection.The higher the serum vitamin A level,the stronger the T cell immunity,but there is no significant correlation between serum vitamin E and T cell immunity.

Key words: recurrent respiratory infection, vitamin A, vitamin E, T cellular immunity

摘要： 目的 研究反复呼吸道感染患儿血清维生素A、E水平与胸腺(T)细胞免疫的关系,以期为此类患儿的临床治疗提供方向。方法 选取2016年3月-2019年8月六安市人民医院收治的60例反复呼吸道感染患儿及53例健康儿童,分别记为研究组和正常组。检测并对比两组儿童血清维生素A、维生素E及细胞免疫学指标,采用Pearson相关性分析法分析研究组儿童维生素A、E与T细胞免疫的关系。结果 研究组维生素A水平分化群(CD) CD3⁺、CD4⁺、CD4⁺/CD8⁺均低于正常组,研究组CD8⁺高于正常组,差异均有统计学意义(P＜0.05);两组维生素E水平相近,差异无统计学意义(P＞0.05);研究组中维生素A水平与CD3⁺、CD4⁺、CD4⁺/CD8⁺指标均呈正相关(r=0.769、0.814、0.796,P<0.05),与CD8⁺指标呈负相关(r=-0.752,P=0.016);维生素E水平与T细胞免疫指标均无相关性(P>0.05)。结论 反复呼吸道感染患儿血清维生素A水平与T细胞免疫呈密切相关性,在一定范围内其水平越高,T细胞免疫能力越强,而血清维生素E与T细胞免疫无显著相关性。

关键词: 反复呼吸道感染, 维生素A, 维生素E, T细胞免疫