Abstract: Objective To investigate the serum levels of vitamin E in healthy children in China,in order to provide basis for dietary guidance. Methods Serum vitamin E levels were measured by reverse phase high performance liquid chromatography(RP-HPLC) with fluorescence detection method.Clinical data of healthy children in the research group of "Study on the correlation between vitamin A and E levels and the development of children′s recurrent respiratory tract infections" were collected and analyzed. Results A total of 41 964 healthy children were included.The average level of vitamin E was(9.12±2.96)mg/L, and serum vitamin E level decreased with the increasing of age(P<0.001) .Vitamin E deficiency and insufficiency rates accounted for 21.49%, of which, the deficiency rate was only 3.36%(1 409/41 964), and the insufficiency rate was 18.13%(7 609/41 964).The vitamin E deficiency and insufficiency rates of children were different in different age groups, which were 4.1% and 13.0% in children under 3 years old and 2.5% and 24.0% in children older than 3 years old, respectively(P<0.001).There was significant difference on the serum level of vitamin E between different regions of China.Children in eastern and central areas whose serum vitamin E levels were in normal range was more than that in western and northeastern areas(P<0.001). Conclusion In general, serum vitamin E level of healthy children in China is in good condition.Vitamin E deficiency and insufficiency accounted for 1/4 of children aged 3 years and over, and further researches are warranted for exploring reasons.

Key words: vitamin E, deficiency, children

摘要： 目的 了解全国健康儿童血清维生素E水平状况,为合理膳食指导提供依据。 方法 利用反相高效液相色谱荧光检测法测定血清维生素E水平,对《维生素A、E水平与儿童反复呼吸道感染疾病发生、发展的相关性研究》课题组中保健门诊健康体检儿童的临床资料进行分析。 结果 符合入组标准儿童共41 964例,血清维生素E水平(9.12±2.96)mg/L,血清维生素E水平随年龄增加有减低趋势(P<0.001)。维生素E缺乏与不足占21.49%,其中,缺乏者仅为3.36%(1 409/41 964),不足儿童占18.13%(7 609/41 964)。不同年龄段儿童维生素E缺乏及不足比例不同,小于3岁组儿童维生素E缺乏、不足分别为4.1%、13.0%;3岁以上儿童维生素E缺乏、不足分别为2.5%、24.0%(P<0.001)。不同区域儿童血清维生素E水平存在差异,东部、中部儿童血清维生素E水平高于西部和东北部儿童(P<0.001)。 结论 我国婴幼儿维生素E营养状况良好,3岁及以上儿童维生素E缺乏及不足者占1/4,原因尚需进一步研究。

关键词: 维生素E, 缺乏症, 儿童