Research advances on the relation between vitamin A deficiency and infectious diseases in children

doi:10.11852/zgetbjzz2020-1142

Abstract

Abstract: Vitamin A is one of the important nutrients for human growth and development. It not only participates in body's metabolism, maintains the body's normal visual response, but also maintains the integrity of the mucosal epithelium. Additionally, vitamin A plays an auxiliary anti-infection role in intestinal infections and respiratory infections. This review will briefly summarize the correlation between vitamin A deficiency and infectious diseases in children.

Key words: vitamin A, infectious disease, children

摘要： 维生素A是人体生长发育重要的营养素之一,不仅参与机体新陈代谢,维持人体正常视觉反应,也维持黏膜上皮完整性,在肠道感染和呼吸道感染中发挥辅助抗感染作用。本文将对维生素A缺乏与儿童感染性疾病的相关性进行简要概述。

关键词: 维生素A, 感染性疾病, 儿童

CLC Number:

ZHANG Li-li, LI Yuan-xia. Research advances on the relation between vitamin A deficiency and infectious diseases in children[J]. Chinese Journal of Child Health Care, 2021, 29(7): 746-750.

张莉莉, 李元霞. 维生素A缺乏与儿童感染性疾病[J]. 中国儿童保健杂志, 2021, 29(7): 746-750.

References

[1] Song P, Wang J, Wei W, et al. The prevalence of vitamin A deficiency in chinese children: a systematic review and bayesian meta-analysis. Nutrients, 2017,9(12):1285.
[2] Bailey RL,West KP,Black RE,et al.The epidemiology of global micronutrient deficiencies[J].Ann Nutr Metab,2015,66(Supple 2):22-33.
[3] Huda MN, Ahmad SM, Kalanetra KM, et al.Neonatal vitamin A supplementation and vitamin A status are associated with gut microbiome composition in bangladeshi infants in early infancy and at 2 years of age[J]. J Nutr, 2019, 149(6):1075-1088.
[4] 程雨嘉,李园,唐瑾.维生素A缺乏与新生儿感染性肺炎发病相关性研究[J].中国儿童保健杂志,2019,27(9):1027-1030.
[5] World Health Organization. Indicators for assessing vitamin A deficiency and their application in monitoring and evaluating intervention programs[R]. Geneva: World Health Organization,1996;
[6] Stevens GA, Bennett JE, Hennocq Q, et al. Trends and mortality effects of vitamin A deficiency in children in 138 low-income and middle-income countries between 1991 and 2013: a pooled analysis of population-based surveys[J].Lancet Glob Health,2015,3(9):e528-e536.
[7] 林晓燕,李云芳,朱云霞.伴有呼吸道感染症状或健康婴幼儿维生素A营养状况与其贫血的关系[J].中国妇幼保健,2020,35(6):1051-1053.
[8] Lee YH, Seo H, Cha SI,et al. A case of pseudomembranous tracheitis caused by Mycoplasma pneumoniae in an immunocompetent patient[J]. Ann Transl Med,2019,7(9):205.
[9] 王迪,胡小琪,徐培培,等.2016年“学生营养改善计划”试点地区学生维生素A营养状况分析[J]. 中国健康教育,2019,35(4):295-299.
[10] Chen G,Du YT,Liu JH,et al.Modulation of anti-malaria immunity by vitamin A in C57BL/6J mice infected with heterogenic plasmodium[J].Int Immunopharmacol,2019,76:105882.
[11] 张云波, 李明伟.维生素A的免疫研究进展[J].中国畜牧兽医, 2014, 41 (3):137-141.
[12] Patel A.Biochemistry, Immunoglobulin A (IgA)[M].Treasure Island (FL): StatPearls Publishing, 2020.
[13] Chen C, Perry TL, Chitko-McKown CG, et al. The regulatory actions of retinoic acid on M2 polarization of porcine macrophages[J]. Dev Comp Immunol, 2019, 98:20-33.
[14] Schwartz E, Zelig R, Parker A,et al. Vitamin A supplementation for the prevention of bronchopulmonary dysplasia in preterm infants: An Update[J]. Nutr Clin Pract, 2017, 32(3):346-353.
[15] Marquez HA, Chen F. Retinoicacid signaling and development of the respiratory system[J]. Subcell Biochem, 2020, 95:151-174.
[16] Albertine KH.Utility of large-animal models of BPD:chronically ventilated preterm lamb[J].Am J Physiol Lung Cell Mol Physiol, 2015, 308(10):983-1001.
[17] 刘奕君.维生素A与肺发育基础及临床研究进展[D]. 重庆:重庆医科大学, 2013.
[18] 陈彦平,陈冬凯,张冬梅,等.维生素A、D、E与儿童反复呼吸道感染相关性的病例对照研究[J].现代预防医学, 2020, 47(9):1598-1602.
[19] Zhang X, Yang K, Chen L, et al. Vitamin A deficiency in critically ill children with sepsis[J]. Crit Care, 2019, 23(1):267.
[20] 陈洪,韩允,罗勇.维生素A缺乏与小儿反复呼吸道感染的相关性[J].中华医院感染学杂志, 2019, 29(22):3415-3418.
[21] Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data[J]. BMJ, 2017, 356:i6583.
[22] Zhang J, Sun RR, Yan ZX,et al. Correlation of serum vitamin A, D, and E with recurrent respiratory infection in children[J]. Eur Rev Med Pharmacol Sci, 2019, 23(18):8133-8138.
[23] 胡楠,李渠北,邹善叶.维生素A辅助治疗儿童肺炎的Meta分析[J].中国当代儿科杂志, 2018, 20(2):146-153.
[24] 李贺晓, 甄庆丰.维生素A对毛细支气管炎患儿免疫状态及预后的影响[J].儿科药学杂志, 2018, 24 (10):22-24.
[25] Xing Y, Sheng K, Xiao X, et al. Vitamin A deficiency is associated with severemycoplasma pneumoniae pneumonia in children[J]. Ann Transl Med, 2020, 8(4):120.
[26] Shen T, Bimali M, Faramawi M,et al. Consumption of vitamin K and vitamin A are associated with reduced risk of developing emphysema: nhanes 2007-2016[J]. Front Nutr, 2020, 7:47.
[27] Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis[J]. Crit Rev Biochem Mol Biol, 2019, 54(2):184-192.
[28] La Frano MR, Brito A, Johnson CM, et al.Metabolomics reveals altered hepatic bile acids, gut microbiome metabolites, and mell membrane mipids mssociated with marginal mitamin A meficiency in a mongolian gerbil model[J]. Mol Nutr Food Res, 2020, 64(13):e1901319.
[29] He C, Hu X, Xiao D, et al. Vitamin A preventslipopolysaccharide-induced injury on tight junctions in mice[J].
Food Sci Nutr, 2020, 8(4):1942-1948.
[30] Iyer N, Grizotte-Lake M, Duncan K, et al. Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18[J]. PLoS Pathog, 2020, 16(4):e1008360.
[31] Li Y, Gao Y, Cui T, et al.Retinoic acid facilitates Toll-like receptor 4 expression to improve intestinal barrier function through retinoic acid receptor beta[J]. Cell Physiol Biochem, 2017, 42(4):1390-1406.
[32] Gattu S, Bang YJ, Pendse M, et al. Epithelial retinoic acid receptor β regulates serum amyloid A expression and vitamin A-dependent intestinal immunity[J]. Proc Natl Acad Sci U S A, 2019, 116(22):10911-10916.
[33] Zhang L, Feng L, Jiang WD, et al. Vitamin A deficiency suppresses fish immune function with differences in different intestinal segments: the role of transcriptional factor NF-κB and p38 mitogen-activated protein kinase signalling pathways[J]. Br J Nutr, 2017, 117(1):67-82.
[34] Abolurin OO, Adegbola AJ, Oyelami OA,et al. Vitamin A deficiency among under-five Nigerian children with diarrhoea[J]. Afr Health Sci, 2018, 18(3):737-742.
[35] Lv Z, Wang Y, Yang T, et al. Vitamin A deficiency impacts the structural segregation of gut microbiota in children with persistent diarrhea[J]. J Clin Biochem Nutr, 2016, 59(2):113-121.
[36] 李春玉, 郑玉瑶, 邹艳红,等.维生素A与婴幼儿迁延性腹泻的调查研究[J].黑龙江医药科学, 2019, 42(1):4-5.
[37] 缪伶伶, 赵慧梅.维生素A用于治疗儿童轮状病毒肠炎的疗效[J].中国医药指南, 2018, 16(21):92-93.
[38] Imdad A, Mayo-Wilson E, Herzer K, et al. Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age[J]. Cochrane Database Syst Rev, 2017,3(3):CD008524.
[39] Masanja H, Mongi P, Baraka J, et al. Factors associated with the decline in under five diarrhea mortality in Tanzania from 1980-2015[J]. J Glob Health, 2019, 9(2):020806.
[40] Kamatsuchi M, Gheorghe A, Balabanova D. The global scale and implications of delivering multiple interventions through integrated child health events[J]. BMJ Glob Health, 2019, 4(4):e001333.
[41] 李春玉,拱国微,邹艳红,等.维生素A与小儿麻疹的相关性研究[J].微量元素与健康研究, 2020, 37(1):58-60.
[42] Chen S,Yang Y,Yan X,et al.Influence of vitamin A status on the antiviral immunity of children with hand,foot and mouth disease[J].Clin Nurt,2012,31(4):543-548.
[43] Vijayaraghavan K. National control programme against nutritional blindness due to vitamin A deficiency:current status & future strategy[J]. Indian J Med Res, 2018, 148(5):496-502.