Exploration of the N400 event-related potential in normal preschool children

doi:10.11852/zgetbjzz2021-1008

Abstract

Abstract: Objective To study the latency, waveform characteristics and development of the N400 component of event-related potential in normal preschool children, so as to provide Objective indicators for early detection of language cognitive impairment in preschool children. Methods A total of 220 normal preschool children aged 3 to 5 years who took physical examination from August 2015 to January 2020 performed sound and shadow matching tasks, and event-related potentials were tested, then the latency and amplitude of N400 in scalp electrodes F_Z, C_Z, and P_Z were recorded.The latency and amplitude of N400 in F3 and F4 were recorded in 127 cases. Results The latency of N400 in 3- to 5-year-old children showed a decreasing trend gradually with increasing age, but the difference was not statistically significant (P>0.05).The amplitude of N400 showed a tendency to decrease gradually with age, and the differences was significant in F_Z and C_Z between 3-year-old children and 4-year-old children [Fz: (-10.95±9.78)μV vs.(-6.40±6.53)μV,Cz: (-12.48±9.45)μV vs.(-7.71±7.80)μV], between 3-year-old children and 5-year-old children [Fz:(-10.95±9.78)μV vs.(-7.01±7.47)μV, Cz: (-12.48±9.45)μV vs.(-7.62±7.90)μV] (P<0.05).Effects of gender and lateralization on N400 latency and amplitude in preschool children were not significant (P>0.05). Conclusion The waveform of N400 is clear and stable in preschool children, with latency and amplitude changing with age.

Key words: event-related potential, N400, preschool children

摘要： 目的了解学龄前正常儿童事件相关电位N400潜伏期、波幅特点和发展规律,为早期发现学龄前儿童语言认知功能障碍提供客观依据。方法对2015年8月-2020年1月健康体检的220例3～5岁学龄前正常儿童进行事件相关电位检测,采用声影匹配任务刺激,记录头皮电极Fz、Cz和Pz点N400的潜伏期和波幅。其中对127例记录了F3、F4点N400的潜伏期和波幅。结果学龄前正常儿童3～5岁组N400的潜伏期随年龄增加有逐渐缩短的趋势,但其差异无统计学意义(P >0.05);N400的波幅存在随着年龄增长逐渐降低的趋势,在Fz点和Cz点3岁～组和4岁～组 [ Fz点(-10.95±9.78) vs.(-6.40±6.53)μV, Cz点(-12.48±9.45) vs.(-7.71±7.80)μV] 、3岁～组和5岁～组[Fz点(-10.95±9.78) vs.(-7.01±7.47)μV,Cz点(-12.48±9.45) vs.(-7.62±7.90)μV]的差异有统计学意义(P < 0.05)。性别和左右侧对学龄前儿童N400潜伏期和波幅的影响不显著(P >0.05)。结论学龄前儿童的N400波形清晰稳定,潜伏期和波幅随着年龄增长而变化。

关键词: 事件相关电位, N400, 学龄前儿童

CLC Number:

R748

ZHU Yi-ke, YIN Yue, LIU Si-qi, ZHANG Fan, WANG Xiao-yue, REN Yong-ying, SUN Jing, WANG Xin, WANG Lin, YANG Jian. Exploration of the N400 event-related potential in normal preschool children[J]. Chinese Journal of Child Health Care, 2022, 30(3): 268-271.

朱一可, 尹悦, 刘思奇, 张樊, 王小月, 任永颖, 孙静, 王昕, 王琳, 杨健. 学龄前正常儿童应用事件相关电位N400的探索性研究[J]. 中国儿童保健杂志, 2022, 30(3): 268-271.

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