Table of Content

10 August 2015, Volume 23 Issue 8

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Expression of apoptosis-related gene programmed cell death 5 in serum of the neonates with hypoxic ischemic encephalopathy.

AN Hong-xia,ZHENG Xing-hui.

2015, 23(8):  788-790.  DOI: 10.11852/zgetbjzz2015-23-08-02

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Objective To investigate the clinical phenotype and IRF6 gene mutation in two Chinese kindred with Van der Woude syndrome (VWS),and understand the mutations of IRF6 and suspicious mutation hotspots in Chinese people.Methods The peripheral blood of 24 members from two VWS families were collected and directly performed the polymerase chain reaction (PCR) for screening the coding region of IRF6 gene.The soft ware of mutation surveyor was used to analysis the sequence.Results There were six VWS subjects in two families,5 (83.3%) patients had cleft lip and palate;5 (83.3%) patients had lip fistula.The results of IRF6 gene sequencing showed,six patients had mutations of IRF6 gene in 24 family members.The c.1234C>T heterozygous mutation was detected in 3 patients of family 1.In family 2,3 patients were carrying c.1210G> A heterozygous mutations.The other members of the families were wild type (wt/wt) for IRF6.Conclusions Based on these findings,the spectrum of mutations in IRF6 associated with VWS is extended.Genetic testing showed that cosegregated with the disease mutation.The identification of the role of IRF6 in VWS may help us to study any possible genotypephenotype relationship by combining molecular genetics.The mutations will play important role in genetic analysis and prenatal diagnosis of VWS.The ultrasound easily missed cleft palate,genetic testing can compensate for the lack of prenatal ultrasound.

A feasibility study of general movements videoed at home in preterm infants follow-up for neurodevelopment.

JIAO Xiao-yan,YANG Hong,LI Jia-yue,ZANG Fei-fei,SHI Yong-sheng,CAO Jia-yan,HE Li,NAN Nan.

2015, 23(8):  791-793.  DOI: 10.11852/zgetbjzz2015-23-08-03

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Objective To analyze the feasibility and the stability of general movements (GMs) videoed at home in preterm infants follow-up for neurodevelopment. Methods The parents were educated to realize the importance of follow-up for early screening and taught them how to obtain qualified GMs videos at home.The obtained videos were sent to GMs group via Internet.Then the researchers analyzed the videos through three aspects:quality,amount,and inter-rater reliability. Results Through relevant education and training,the quality of GMs videos videoed at home could be close to the standardization of clinical videos,and could be videoed sequentially and had a good inter-rater reliability. Conclusion The GMs videos videoed at home has the feature of feasibility.It can be used as the supplement of standard general movements assessment and be suitable to apply to less developed areas.

Predictive value of fidgety movements assessment for motor development outcomes in premature infant.

HUANG Tian,WANG Zhao-hui,LI Yan-hui,ZHANG Yong,JI Yi-lun,LI Hong-juan,GAO Hong.

2015, 23(8):  794-796.  DOI: 10.11852/zgetbjzz2015-23-08-04

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Objective To compare the validity and concordance in the motor developmental outcomes of General Movements assessment (GMs) with that of Gesell Developmental Test Scale (GDS)among premature infants.Methods 226 premature infants doing physical examination and follow-up in Department of Children's Health Care of our hospital during June 2011 to June 2013 were evaluated with GMs assessment and Gesell Developmental Test Scale.Cerebral palsy was evaluated and the motor development was assessed by Peabody Development Motor Scale 2 (PDMS-2) in correct gestational age 12 month.Compare the predictive validity (sensitivity,specificity,positive predictive value and negative predictive value) and motor development of the two methods.Results There were 28 cerebral palsy patients and 22 infants with motor retardation among the 226 premature infants，meanwhile 176 were normal.For the fidgety movements of GMs,168 infants were assessed as normal,58 were abnormal.GDS assessment results:There were 140 infants were assessed as normal and 86 infants were abnormal.The fidgety movements of GMs assessments and GDS assessment sensitivity for cerebral palsy was 92.9%,71.4%,its specificity was 83.8%,66.7%,its positive predictive value was 44.8%,23.3%，its negative predictive value was 98.8%,94.3%.The fidgety movements of GMs assessments and GDS assessment sensitivity for motor development outcome was 88.0%,68.0%,its specificity was 92.0%,70.4%,its positive predictive value was 75.9%,39.5%，its negative predictive value was 96.4%,88.6%.The Kappa value for consistency checks of GDS and PDMS-2 was 0.306，p<0.05.The p value for consistency checks of GMs and PDMS-2 was 0.757，P<0.05.The results hint that a good consistency of GMs and GDS and PDMS-2.The consistency of prediction and assessment result of fidgety movements was higher than other methods.Conclusions Fidgety movements of GMs can make early prediction of cerebral palsy and other severe neurological deficits.It is better than the traditional method neurological examination in predicting prognosis.

Study on the status of diarrhea among the 607 children under the age of 3 years in rural Lhasa.

KANG Yi-jun,DUOJI Zhuo-ma,WANG Guo-dong,DANG Shao-nong,YAN Hong,WANG Quan-li.

2015, 23(8):  797-800.  DOI: 10.11852/zgetbjzz2015-23-08-05

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Objective To estimate two-week prevalence rate of diarrhea and explore the influencing factors of diarrhea among the children under the age of 3 years in rural Lhasa. Method A Cross-sectional design with multi-stage cluster random sampling method was adopted in this study,and a face-to-face interview was conducted to collect the information of socio-economic household and diarrhea within two weeks.All information was obtained by recalling from the respondents. Results The two-week prevalence rate of diarrhea among the children was 17.3%.The prevalence was higher in boys (17.6%) than girls (16.9%),but the difference was not significant (P＞0.05).The two-week prevalence rates of diarrhea among children with different age groups were 16.5%,28.4%,25.0%,10.9%,9.8%,and 4.9% in 0~5,6~11,12~17,18~23,24~29,and 30~35 months aged group,respectively.The differences of prevalence among the different age groups were significant (P＜0.05),and the prevalence was highest in 6~11 months of age.The Logistic regression model was used to analysis the possible influencing factors of two-week diarrhea among the children under the age of 3 years.Finally,the factors such as the age of children,whether catch a cold in the past two weeks,the poorer sight of mother at night during pregnancy than before,the age of children when added protein complimentary foods and the pan used to cook in family had strong relationships with the two-week prevalence rate of diarrhea among children (P<0.05). Conclusion The two-week prevalence rate of diarrhea among the children under the age of 3 years is high in rural Lhasa.In order to reduce the two-week prevalence rate of diarrhea,the mother should be educated on how to raise their children,strengthening nutrient supplementation during pregnancy,and introducing protein complementary foods timely should be especially promoted by the local government.

Detection of interferon regulatiory factor 6 mutation in two Van der Woude syndrome families.

LI Shou-xia,ZHANG Xiao-fang,CHEN Ding-li.

2015, 23(8):  801-803.  DOI: 10.11852/zgetbjzz2015-23-08-06

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Objective To investigate the clinical phenotype and IRF6 gene mutation in two Chinese kindred with Van der Woude syndrome (VWS),and understand the mutations of IRF6 and suspicious mutation hotspots in Chinese people. Methods The peripheral blood of 24 members from two VWS families were collected and directly performed the polymerase chain reaction (PCR) for screening the coding region of IRF6 gene.The soft ware of mutation surveyor was used to analysis the sequence. Results There were six VWS subjects in two families,5 (83.3%) patients had cleft lip and palate;5 (83.3%) patients had lip fistula.The results of IRF6 gene sequencing showed,six patients had mutations of IRF6 gene in 24 family members.The c.1234C>T heterozygous mutation was detected in 3 patients of family 1.In family 2,3 patients were carrying c.1210G> A heterozygous mutations.The other members of the families were wild type (wt/wt) for IRF6. Conclusions Based on these findings,the spectrum of mutations in IRF6 associated with VWS is extended.Genetic testing showed that cosegregated with the disease mutation.The identification of the role of IRF6 in VWS may help us to study any possible genotypephenotype relationship by combining molecular genetics.The mutations will play important role in genetic analysis and prenatal diagnosis of VWS.The ultrasound easily missed cleft palate,genetic testing can compensate for the lack of prenatal ultrasound.

Prenatal diagnosis of fetal β-thalassemia gene for the couples carried with the β-thalassemia gene in Huizhou city.

ZHU Xiao-jie,LIU Yu-peng,LIU Rui-yu,YU Xiao-yan,LIN Min,CHEN Jiang-tao,LI Xu-yan,HE Li.

2015, 23(8):  804-806.  DOI: 10.11852/zgetbjzz2015-23-08-07

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Objective To investigate gene carrier rates,mutation types and distribution characteristics of β-thalassemia among the fetus of couples who carried with the β-thalassemia gene in Huizhou city. Methods For 116 couples carried with the β-thalassemia gene,fetal villus tissues were collected at the first trimester,cord blood or amniotic fluid were collected at the second trimester,and cord blood were collected at the third trimester.Insitu cultivation was performed for cells in amniotic fluid and villus tissues.Hematology and hemoglobin analysis were performed for cord blood.β-thalassemia gene was detected for tissues before and after cultivation or for cord blood. Results Among 116 fetuses,27 cases were definitely diagnosed with severe β-thalassemia which accounted for 23.28% and 56 cases were carriers which accounted for 48.28%.11 types of β-thalassemia mutation and 21 kinds of genotypes were detected and the top four were as followed:CD41-42 (26.51%),IVS-Ⅱ-654 12 ( 14.46%),CD-28 (10.84%),CD17(6.02%).56 cases were single heterozygous mutation which included 9 kinds of genotypes.24 cases were double mutant heterozygotes which included 10 kinds of genotypes.3 cases were single mutant homozygotes which included 2 kinds of genotypes.Rare mutation were detected which were 1 case of CD14-15 and 1 case of CD41-42/43 respectively. Conclusion This study shows the incidence and mutation rates of β-thalassemia among the fetus of couples carried with the β-thalassemia gene,which provides a scientific basis for prevention of thalassemia in Huizhou city.

Effect evaluation of the first permanent molars sealant program for schoolchildren in Xincheng district of Xi'an,China.

LI Jun,WANG Yan-bo,ZHANG Song-jie,WANG Lei,HUANG Ying,GAO Jian-min.

2015, 23(8):  807-810.  DOI: 10.11852/zgetbjzz2015-23-08-08

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Ojective To evaluate the prevention effects of a school-based pit and fissure sealant program to the dental caries of the first permanent molar of the schoolchildren in Xincheng district of Xi'an,China. Methods By the method of retrospective cohort study,the class took as a whole group to make random cluster sample and 760 children aged 10~12 years old,were divided into sealant group (464 children) and control group (296 children) according to whether or not to participate in pit and fissure sealant program,their general demographic information,oral hygiene habits,knowledge,attitude,etc were surveyed.History oral examination results of them were used to evaluate the risk of dental caries.The FPM caries situation was compared between two groups,and the pit and fissure sealants reserved were checked in the sealant group. Result With the one-time sealant application,follow-up time was (2.63±0.09) years,The complete sealant retention rate of occlusal surfaces was significantly higher than that of buccal/lingual surfaces (62.9% vs 18.8%,χ²=184.64,P=0.000).The caries/restored rate on buccal/lingual surfaces was significantly higher than that of occlucal surfaces (10.4% vs 6.2%,χ²=7.89,P＜0.01).The odds ratio for dental caries was 6.11(95%CI=4.28～8.73)compared between no sealed occlucal surface and sealed ones.Unconditional logistic regression analysis showed that sealant retention was a remarkable protect factor for the FPM(AOR:0.07,95%CI:0.03～0.17).Using direct standardization to control the different caries risk ratio of children in two groups,the caries rate of the first permanent molar in sealant group and in control group was 12.4% and 17.6% respectively,the reduction of attack rate was 29.6%. Conclusion The school-based pit and fissure sealant program had prevent effects on dental caries of schoolchildren in Xincheng district of Xi'an.

Intelligence structure characteristic of attention deficit hyperactivity disorder children with mathematical difficulties in WISC-Ⅳ.

HU Hua-yun,WU Jie-ling,LIN Wen-xuan,HE Yan-si,LI Ying,YAO Xiao-min.

2015, 23(8):  811-813.  DOI: 10.11852/zgetbjzz2015-23-08-09

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Objective To explore the intelligence structure characteristic of attention deficit hyperactivity disorder (ADHD) children with mathematical difficulties in WISC-Ⅳ.Method 30 children who were diagnosed ADHD according to Diagnostic and Statistical Manual (DSM-Ⅳ),both math scores lower than the same grade tenth percentile and language achievements are not lower than the same grade the fiftieth percentile.With gender and age matched,30 children who were diagnosed ADHD,both language and math achievements are not lower than the same grade the twenty-fifth percentile were selected by systematic sampling method.WISC-Ⅳ were used to test and analyze the intelligence distribution and structure of these children.Results The FSIQ and the 4 index scores of MD-ADHD children were lower than that of ADHD children with statistical difference (P<0.05),In the subtests,the LN,DS,CD,MR,BD and CO scores of MDADHD children were lower than those of ADHD children with statistical difference (P<0.05).Conclusion WISC-Ⅳ test the children's general cognitive ability,the children of MD-ADHD showed special cognitive structure characteristics,and we should take some individual guidance and trainings according to the cognitive abilities feature of math learning.

Value of tandem mass spectrometry analysis in diagnosis of high risk children with inherited metabolic diseases.

WANG Xue-ying,JANG Yong-sheng,LI Dan,YANG Lin,HUANG Shao-ping,SONG Ting-ting,LIU Yu.

2015, 23(8):  814-816.  DOI: 10.11852/zgetbjzz2015-23-08-10

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Objective To explore the value of tandem mass spectrometry analysis in diagnosis of high risk children with inborn errors of metabolism(IEM).Methods From January 2010 to December 2013,617 cases who were suspected inborn errors of metabolism were collected to be tested by tandem mass spectrometry (MS/MS).Screening positive cases for the urinary metabolic screening or genetic testing had been confirmed,and the related clinical data were analyzed and summarized in this paper.Results In the 617 cases,a total of 24 cases (3.9%) were diagnosed with 10 kinds of inborn errors of metabolism.4 cases (16.7%) were amino acid metabolic diseases in which citrullinemia was common.14 cases (58.3%) were organic acid metabolism disorder in which methylmalonic acidemia was common.Medium-chainacyl-CoA dehydrogenase deficiency (2 cases) and mitochondrial encephalomyopathy (2 cases) were common in fatty acid dysoxidation (6 cases 25%).Conclusion Pediatricians should attach importance to the utilization of MS/MS in detection of inherited metabolic disorders in order to early diagnosis and early intervention.

Protective effects of ethyl pyruvate on expressions of 12-lipaxygenase and apoptosis on rat's offspring's damaged brain caused by intrauterine infection.

KONG Xiang-ying,LI Xiao-jie,SONG Fu-xiang,Rajesh.

2015, 23(8):  817-820.  DOI: 10.11852/zgetbjzz2015-23-08-11

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Objective To study the effect of ethyl pyruvate(EP) in the expression of 12-lipoxygenase(12-LOX) and apoptosis changes on rat's offspring's damaged brain caused by intrauterine infection. Methods Pregnant wistar rats of lipopolysaccharide(LPS) group were consecutively injected with lipopolysaccharide [380 μg/(kg·day)] intraperitoneally.Pregnant Wistar rats of EP group were consecutively injected with LPS intraperitoneally,and EP was administrated intraperitoneally at a dose of 40 mg/kg immediately.12 pregnant rats were injected with normal saline intraperitoneally as control group.After the delivery of pups,thirty-six pups were selected in every group randomly.placenta from rats of LPS group was taken for hematoxylline-eosin (HE) staining to confirm its intrauterine infection.12-LOX expression in brain tissue was studied through immunohistochemical and western-blot analysis.TUNEL was used to observe the pathological changes of the brain tissue. Results Obvious pathological changes were observed in the placenta in the infection groups.The expression of apoptosis was lower in EP group and NS group than in the LPS group (P<0.05),and lower in NS group than that in the EP group (P<0.05).The expression of 12-lipoxygenase was lower in EP group and NS group than that in the LPS group (P<0.05),and lower in NS group than that in the EP group (P<0.05). Conclusion EP confers potent protection against LPS-induced brain injury via significantly reduced the expression of 12-LOX and anti-apoptotic properties.

Influence of early nutritional status on neurologic development in very low birth weight infants.

ZHAO Xiao-peng,ZHOU Wei,LIANG Hong,SONG Yan-yan,WANG Lan-xiu,ZHANG Ting-yan,SHEN Ting.

2015, 23(8):  837-839.  DOI: 10.11852/zgetbjzz2015-23-08-17

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Objective To investigate the effects of early nutritional status of very low birth weight infants (VLBWI) in neonatal intensive care unit (NICU) on their neurologic development thereafter.Methods The study was conducted in NICU of Guangzhou Women and Children's Medical Center from January 2013 to June 2014.A total of 86 VLBWIs who met the entry criteria had been followed up in highrisk infant outpatient service after leaving hospital regularly,and they were assigned to two groups (normal neural development group and abnormal neurologic development group) according to their development quotients (DQ) examined through development test at 3 months corrected age,then their nutritional status were analyzed during hospitalization respectively.Results In normal neurologic development group,the gross energy and the proportion of enteral energy were higher compared with abnormal neurologic development group on 4 d,7 d and 14 d after birth,and the supply of amino acids was also higher than that abnormal neurologic development group on 4 d and 7 d after birth,the statistical differences were significant (P＜0.05);Compared with abnormal neurologic development group,the weight reduction of VLBWIs in normal neurologic development group was less and they could revert to birth weight and achieve full gastrointestinal feeding earlier,the difference between two groups had statistical significance (P＜0.05).Conclusion Early better nutritional status of VLBWI can improve the effects of their neurologic development significantly.

Clinical analysis of glucose-6-phosphate dehydrogenase deficiency in 1 792 cases of neonatal hyperbilirubinemia.

XIANG Fei-yan,XIAO Han,LIU Xiu-zhen.

2015, 23(8):  840-842.  DOI: 10.11852/zgetbjzz2015-23-08-18

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Objective To review the glucose-6-phosphate dehydrogenase (G6PD) deficiency in cases of neonatal hyperbilirubinemia(NHB) to prevent hyperbilirubinemia in early neonatal stage and hemolysis in lifelong. Methods The activity of G6PD was detected by the method of quantitative G6PD/6-phosphaogluconate dehydrogenase (6PGD) ratio and the clinical features of total bilirubin(TB),unconjugated bilirubin(UCB),red blood cell count (RBC),hemoglobin(Hb) level were reviewed. Results A total of 24 cases(23 male infants and 1 female infants) of G6PD deficiency were detected among the 1 792 newborns with hyperbilirubinemia.The serum TB was (34.3±177.6)μmol/L,mean RBC and Hb levels were (3.51±0.88)×10¹² /L and (121±27)g/L respectively.There was no significant correlation between TB and G6PD/6PGD ration,RBC,or Hb. Conclusions For the causes to NHB,G6PD deficiency is characterized by early onset,rapid progression levels of G6PD,RBC,Hb can not reflect the severity of jaundice.G6PD screening for neonatal hyperbilirubinemia is necessary to execute as soon as possible.

Evaluation of serum procalcitonin as a early diagnostic marker of premature ventilator-associated pneumonia.

CHENG Gui-hui,CUI Qi-liang,QIU Qi-zhou,WANG Ying-hong,XIONG Wei,XIAO Yi.

2015, 23(8):  843-846.  DOI: 10.11852/zgetbjzz2015-23-08-19

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Objective To evaluate the diagnostic value of procalcitonin (PCT) in premature ventilator-associated pneumonia (VAP). Methods 126 cases of preterm infants were divided into mechanical ventilation group and non mechanical ventilation group(the control group).81 preterm infants on ventilators were divided into VAP group and non-VAP group depending on whether the patients developed VAP.The levels of blood PCT,C-reactive protein (CRP) and the white blood cell (WBC) of preterm infants with mechanical ventilation group before the mechanical ventilation and after 48 hours were retrospectively analyzed,and compared with the control group. Results There were no significant differences of PCT,WBC,CRP in the VAP group,non-VAP group and the control group before mechanical ventilation (P>0.05).At 48 hours after mechanical ventilation,there were no significant differences of WBC in three group (P>0.05).But there was not all equal of PCT or CRP between the three groups,and the PCT and CRP showed obvious difference in VAP group compared with non-VAP group and the control group( all P<0.000 ),and there were no significant differences of PCT and CRP in non-VAP group and the control group (P>0.05).The area under the curve (AUC) of receiver-operation characteristics (ROC) was 0.936 for PCT and 0.702 for CRP to diagnose premature ventilator-associated pneumonia,there was significant differences (P=0.000). Conclusion The PCT for early diagnosis of neonatal VAP has higher accuracy than CRP and WBC.

Comparison of predictive validity of two assessment methods for gross motor outcome and cerebral palsy in high risk infants.

ZHONG Chen,YANG Hong,WANG Wen-xiang,ZHOU Li-feng,ZHANG Xiao-li.

2015, 23(8):  856-858.  DOI: 10.11852/zgetbjzz2015-23-08-23

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Objective To compare qualitative general movements assessment (GMs assessment) and 20 items neurological assessment from birth to 1 year (20 items assessment) for gross motor outcome and cerebral palsy in high risk infants.Methods According to the inclusion criteria,30 infants were confirmed as the participants.GMs and 20 items were assessed one times during fidgety movements period (correct age from 9 weeks to 5 months).Gross motor outcome and cerebral palsy were determined by clinic performs and Peabody Developmental Motor Scale at least after one year old.Sensitivity,specificity,positive predictive value,negative predictive value and Kappa index were calculated.Results 3（10%） infants were cerebral palsy,5 (16.7%) infants were gross motor retardation,25(83.3%) infants were normal gross motor development.Predictive validity of GMs for gross motor retardation was as follows：sensitivity 80.0%,specificity 96.0%,positive predictive value 80.0%,negative predictive value 96.0%；Predictive validity of 20 Items for gross motor retardation was as follows：sensitivity 100.0%,specificity 92.6%,positive predictive value 60.0%,negative predictive value 100.0%；Predictive validity of GMs for cerebral palsy was as follows：sensitivity 100.0%,specificity 92.6%,positive predictive value 60.0%,negative predictive value 100.0%；Predictive validity of 20 Items for cerebral palsy was as follows：sensitivity 100.0%,specificity 85.2%,positive predictive value 42.9%,negative predictive value 100.0%；Kappa=0.59.Conclusions During fidgety movements period，predictive validity for gross motor retardation of two methods have advantages,GMs is better at predicting cerebral palsy.Two methods with moderate consistency,have comprehensive application in high risk infants follow-up work.

Investigation of perinatal birth defects from 2001 to 2013 in Pingyin,Shandong province.

XU Xin,LI Shi-xue,ZHAO Si-qi,YU Zhi-xia.

2015, 23(8):  859-861.  DOI: 10.11852/zgetbjzz2015-23-08-24

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Objective To analyze the data of birth defects from 2001 to 2013 in Pingyin,and to provide a basis for making effective interventions to reduce birth defect ratio. Methods The datas of perinatal in Pingyin nearly 14 years were investigated and collected,the birth ratio,categories and relevant factors were analyzed in descriptive statistical methods. Results The perinatal birth defects ratio was 10.8‰,the prenatal diagnosis ratio was 20.7%.The top five birth defects categories were hydrocephalus,hypospadias,deformity of external ears,cleft lip and palate,kidney malformation.The male birth defect ratio was higher than that of female,the multiple births was higher than single birth,the maternal age <20 and >35 were higher than other age groups (P all<0.05),there was no significant difference between urban and rural areas. Conclusions The birth defects is related to gender,maternal age as well as the embryo number.The birth defects ratio in Pingyin is lower than the average of China.The prenatal diagnosis rate should be raised for reducing the birth defects.There is great potential for the development of prenatal diagnosis technologies.

Investigation of the life quality of cerebral palsy children with spasm pain.

LIU Zhen-huan,DONG Shang-sheng.

2015, 23(8):  862-864.  DOI: 10.11852/zgetbjzz2015-23-08-25

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Objective To assess the life quality of the cerebral palsy (CP) children with spasm pain.Methods The method of cross-sectional case-control was used to investigate the life quality of 54 cerebral palsy children with spasm pain and 100 normal children by Pediatric Quality of Life Inventory TM Version 4.0 (PedsQLTM4.0).Results The scores (physical functioning,psychological functioning,emotional functioning,school functioning and total score)of study group were lower than those of the normal group (P<0.05);the scores had no statistical significances between the female and male;the scores of the five part had no statistical significances between 2~4 years old age group,5~7 years old age group and 8~13 years old age group(P>0.05);The scores of physical functioning and psychological functioning of 1~2 level of GMFCS (Gross Motor Function Classification System) were higher than those of the 3~5 level (P<0.05),the scores of other three part had no statistical significances (P>0.05);the score of physical functioning and school functioning had positive correlations with the total score of GMFM-88 (r=0.478,0.413,P<0.05).Conclusion The life quality of the cerebral palsy children with spasm pain is worse than the normal children,and the severity of their life quality has significant correlation with gross motor function.

Comparative study on early motor development of late preterm and term infants.

ZHANG Xue-mei,ZHANG Li-juan.

2015, 23(8):  865-866.  DOI: 10.11852/zgetbjzz2015-23-08-26

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Ojective To investigate the differences of early motor development between late preterm and term infants.Methods 46 cases of late preterm infants who were born and followed-up in our hospital were selected as observation group.50 term infants who were born during same period of time in our hospital were randomly selected as control group.Through use of Alberta Infant Motor Scale (AISM),infants of two groups aged (14.0±1.0) weeks were assessed on motor development.Original scores,rate of percentile≥50% and abnormal rate of motor development of two group were compared.Results AISM original scores of late preterm group was lower than that of term infants group,but the difference was not statistically significant.The corresponding rate of percentile≥50% of late preterm group was lower than that of term infants.Difference was statistically significant (P<0.01).The difference on abnormal rate of motor development between late preterm and term infants was statistically significant (P<0.05).Conclusions Late preterm infants are high risk of neurodevelopmental outcomes.Their early motor development trend with corrected gestational age is usually later than term counterparts.Early intervention should be implemented as soon as possible to promote good development for premature infants.

Analysis on monitoring 41 cases of adsorbed acellular DPT combined vaccine adverse events following immunization.

CHEN Yu-rong,ZHANG Jie,YANG Xiao,LIU Chun-fan,WU Dong-hong.

2015, 23(8):  867-869.  DOI: 10.11852/zgetbjzz2015-23-08-27

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Objective To analyze influencing factors of adsorbed acellular DPT combined vaccine (DTaP) adverse events following immunization (AEFI) and improve the AEFI management.Methods From January 2011 to December 2014 in Navigation Road community health service center of our hospital,41 cases with DTaP AEFI reaction were retrospectively monitoring analyzed.Results During the period of DTaP inoculation,28 494 children aged from three months to 2 years were vaccinated,41 children appeared AEFI reaction,the incidence rate was 0.144%.Compared through 4 years,the AEFI reaction rate showed a downward trend in overall (χ2=8.614,P=0.035).Conclusions Data showed,AEFI appeared in each month throughout the year.AEFI reaction rates were higher in the month of August and July,with a high trend in summer,and often occurred in the third or fourth pin.The AEFI of DTaP vaccine was related with inherent characteristics,children's age,inoculation time,inoculation time,seasonal vaccination and other related technology.Strictly standardized safety operation,close attention to the vaccination contraindication and the high incidence time of AEFI,completing the vaccination information warning,could reduce the AEFI.

Analysis on risk factors of parenteral nutrition-associated cholestasis in extremely low birth weight infants.

YUAN Ying-ying.

2015, 23(8):  870-872.  DOI: 10.11852/zgetbjzz2015-23-08-28

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objective To explore the risk factors of parenteral nutrition-associated cholestasis (PNAC) in extremely low birth weight infants(ELBWI). Methods The clinical data of 229 ELBWI receiving parenteral nutrition (PN) for more than two weeks in neonatal intensive care unit (NICU) were retrospectively analyzed.The differences between PNAC group and non-PNAC group about gestational age,birth weight,sex,et al were compared. Results The incidence of PNAC was 11.79%(27/229).Compared with non-PNAC group,the average gestational age and birth weight in PNAC group were lower; Average PN duration,average energy intake,the large fat milk dosage and accumulative dosage were higher;The incidence of infection and anemia in PNAC group were higher too(P<0.05). Conclusion The incidence of PNAC is associated with lower gestational age,lower birth weight,longer PN duration,higher energy intake,larger fat milk dosage and accumulative dosage,infection and anemia.

Prevalence of dental caries in junior kindergarten of Jiangsu province:an epidemiological study.

WANG Ya-lin,QIN Rui,CHEN Ya-ming,ZHANG Yan-fang,YAN Sen.

2015, 23(8):  873-874.  DOI: 10.11852/zgetbjzz2015-23-08-29

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Objective To determine the prevalence of deciduous tooth caries and its influencing factors among junior kindergarten children of Jiangsu province,and to make recommendation for prevention of dental caries. Methods A closed ended questionnaire according to WHO 1997 methodology was used to collect the data.An epidemiological stratified cluster sampling method was carried out among 25 862 children in junior kindergarten in 13 area of Jiangsu,and the children were examined for the presence of dental caries(at the same time tooth fluoride). Results The overall prevalence of deciduous tooth caries was 41.89% for junior kindergarten of Jiangsu province.Dental caries prevalence of maxillary dentition from high to low was:deciduous teeth,primary lateral incisor,second deciduous molar,first deciduous molar and canine.However,the prevalence of mandibular dentition from high to low was:second deciduous molar,first deciduous molar and mandibular anterior teeth.The prevalence of dental caries in rural was considerably higher than that in urban(P＜0.01),and the prevalence in 4 years old children was extremely high compared with 3 years old children(P＜0.001).However,the prevalence of dental caries had no gender difference (P＞0.05). Conclusions The study concludes that the prevalence of dental caries in junior kindergarten children of Jiangsu province is high.It is necessary to introduce oral health knowledge and increase fluoride application for reducing the caries prevalence of primary dentition and maintaining children of those caries.

Investigate on routine immunization coverage rate of children and analysis on management quality of vaccination clinics in Jiaxing.

DU Zhe-qun,HE Ben,XIANG Ze-lin,ZHU Hong-liang,SHEN Guo-chu.

2015, 23(8):  875-877.  DOI: 10.11852/zgetbjzz2015-23-08-30

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Objective To learn the current status,immunization coverage rate and the related factors affecting the quality of management with planed immunization. Method The data were analyzed through China Immunization Information System and field surveys of children. Results In Jiaxing,the routine immunization coverage rate of 5 kinds of vaccines over 2 years old were 98.98%.The strengthen immunization coverage rates over 7 years old were all above 97%.In addition to there were 95.28% and 74.25% in local and migrant children respectively of A+C meningitis second needle.The building permit rates of site investigation were 99.84%,and the rates of the book cards were 97.58% with children.The city had 79 vaccination clinics for credible information and 7 units of untrusted by telephone verification.The management of children with temporary vaccination in vaccination clinics,61 units was fine(accounting for 70.93%),15 units(accounting for 17.44%) was medium and 10 units was poor(accounting for 11.63%). Conclusion By optimized the immunization services,created a new model of health promotion and explored appropriate measures for local migrant children integrated management mechanism,the city's vaccination rates with children and management level of vaccination clinics were improved,the construction of modern vaccination clinics for sustainable development was promoted.

Analysis of hospitalized children death cases in Wuhan Children's Hospital from 2003 to 2014.

SONG Xin-wen,YANG Han-jun.

2015, 23(8):  878-880.  DOI: 10.11852/zgetbjzz2015-23-08-31

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Object To analyze the age distribution,death time,cause of death,hospital mortality of hospitalized children death cases in Wuhan Children's Hospital during nearly twelve years,and try to point out the variation trend. Methods A retrospective statistical analysis was used on 1 179 hospitalized children death cases from 2003 to 2014 in Wuhan Children's Hospital. Results The total mortality among hospitalized children was 0.19% from 2003 to 2014.In previous 10 years,the alteration of mortality rate in each year had no significance.From the beginning of 2013,the trend of mortality rate was decreased.The majority death age of hospitalized children death case was neonatal,accounted for 39.02%.The second was 1 year old infants,accounted for 31.98%.And most of the time of death was within 9 days after admission.In accordance with the system to classification,the top five causes of death were neonatal disease,respiratory diseases,congenital malformations,nervous system diseases and digestive diseases,respectively.The top five diseases of death were pneumonia,congenital heart disease,central nervous system infections,sepsis and neonatal pneumonia,respectively. Conclusions The focal point of reducing hospitalized children death is improving the level of diagnosis and treatment of dangerous diseases,such as neonatal disease,infectious diseases and congenital malformation.

Study on premature infants' immune response and adverse reaction to hepatitis B,polio and measles vaccination.

LIU Qiong-fang.

2015, 23(8):  883-884.  DOI: 10.11852/zgetbjzz2015-23-08-33

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Objective To discuss the immune effect and the adverse reaction incidence of the premature infants after hepatitis B,Polio and Measles vaccination. Method 105 premature infants vaccinated in the vaccination clinic of Xianning Center for Disease Control and Prevention between 2010 and 2013 were selected as observation group,while another 105 full-term infants were chosen as control group.The incidence of adverse reactions and abnormal responses were compared 72 hours after the two groups of newborn babies were inoculated with hepatitis B,polio and measles vaccines,and the immune success rates with ELISA one or two months after the three types vaccination were tested. Result The adverse reactions to the vaccination after 72 hours: hepatitis B and measles vaccination may cause fever and local swelling,polio vaccination may cause fever and diarrhea.The immune success rates of hepatitis B,polio and measles vaccines were 85.71%,89.52%,88.10% respectively. Conclusion Same as the full-term infants,the premature babies have good immune responses to hepatitis B,polio and measles vaccines.There is no significant difference in the incidences of adverse reactions to the three vaccines between full-term infants and premature babies.

Diagnosis of two cases with 7p11.22 microdeletion by applying array-based comparative genomic hybridization.

WU Bin-bin,XU Ke-qian

2015, 23(8):  885-887.  DOI: 10.11852/zgetbjzz2015-23-08-34

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Objective To investigate the diagnosis of 2 cases with 7q11.22 microdeletion by applying array based comparative genomic hybridization (aCGH) and to analyze the relationship between the clinical manifestations and 7q11.22 microdeletion. Method The aCGH technique was used to detect genomic copy number variations (CNVs) in 2 cases with normal karyotype after conventional chromosomal karyotyping. Result The aCGH detected 7q11.22 deletion (chr7:69479621-69539140 and chr7:69945652-70019838),which was confirmed as pathogenic CNV after comparative analysis with database. Conclusion The array-CGH could serve as a useful complement for G-banding and to be used in the clinical cytogenetic diagnosis.

Establishment and application of neonatal health care platform based on WeChat Public Platform.

ZHAO Qing,ZHU Li-wei,GUO Wen-tao.

2015, 23(8):  888-890.  DOI: 10.11852/zgetbjzz2015-23-08-35

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Objective Through Neonatal Health Care Platform based on WeChat Public Platform to evaluate the effort of this platform in neonatal health care. Methods To choose early pregnant women who were need pregnancy test,they were divided into subscription group and non-subscription group according to whether subscribe the neonatal health care platform based on WeChat public platform.Using the platform to disseminating neonatal health care knowledge for subscription group to observe and assess the newborns of the two groups. Results In comparison of subscription and non- subscription group,there were significant differences in acceptances of phenylketonuria screening,thyroid hypofunction screening,hearing screening and neonatal behavior neurological assessment;The subscription group was better than non-subscription group in the conditions of weight growth of newborns after birth 28 days and pure maternal breast-feeding;In mastering situation on neonatal care knowledge,the subscription group was better than non-subscription group;The subscription group had lower morbidity rates than non-subscription group in some diseases. Conclusion To spread on neonatal health care knowledge by establishment of neonatal health care platform based on WeChat public Platform can achieve the promotion the healthy growth of newborns and prevention of disease.

Discussion on evaluation and training model of middle school student first aid skills training in Yinchuan area.

HAN Zi-hua,TIAN Ji-an,QIAO Yi,ZHU Jin,LI Hai-yan,HU Li.

2015, 23(8):  891-894.  DOI: 10.11852/zgetbjzz2015-23-08-36

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Objective To explore first aid knowledge skills training model that suitable for middle school students through the baseline investigation and analysis of Yinchuan area middle school students to master degree of first aid knowledge skills. Methods By designed questionnaire,2 112 middle school students' first aid knowledge were tested before training,and then the training effect with the same questionnaire were tested after training.With "participatory teaching method",the middle school students learned first aid knowledge and skills in emergency scenario design,skills operation,and interactions between schoolmates.The first aid skills operation training effect was tested before and after training.Among 2 112 students,300 students of 12 years old,13 years old,14 years old were randomly selected,related data were collected for statistics and analysis,the training effect was evaluated . Results Qualified rate of different gender,age,area before and after training had statistically significant difference (P<0.05);In trauma,dog bites,cardiopulmonary resuscitation (CPR),burns,drowning,airway foreign bodies blocked,the six knowledge awareness of training in gender,age,region had significant difference (P<0.05) before and after training.76.84% of the students liked "game" training form,70.52% liked "work in practice operation" training form ,and 63.19% liked "role play" training form. Conclusion The participatory teaching method to the first aid knowledge and skills training in the middle school students have obvious effects,the method is effective and worth popularizing in the whole country.