Advances in research of filament middle cerebral artery occlusion model and neuroprotective agents

Abstract

Abstract: Ischemic stroke is the pathological process caused by reduced cerebral blood flow due to cerebrovascular thrombosis or embolism. Middle cerebral artery occlusion model serves as an indispensable tool to investigate mechanisms of ischemic cerebral injury and develop novel anti-ischemic regimens. This paper reviews the strengths and weaknesses of filament middle cerebral artery occlusion model and promising neuroprotective agents.

Key words: middle cerebral artery occlusion, neuroprotective, mechanism

CLC Number:

R654

LIANG Zheng-yu, TANG Song-shan, ZHOU Dong. Advances in research of filament middle cerebral artery occlusion model and neuroprotective agents[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(9): 1069-1074.

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