钒酸盐管饲对STZ糖尿病大鼠OGTT和理糖激素的影响

中国临床药理学与治疗学 ›› 1999, Vol. 4 ›› Issue (2): 93-97.

钒酸盐管饲对STZ糖尿病大鼠OGTT和理糖激素的影响

金文胜, 张忠辉¹, 张平¹

广州军区广州总医院内分泌科 510010,¹第三军大学西南医院内分泌科 400038

收稿日期:1999-01-18 修回日期:1999-04-11 出版日期:1999-06-26 发布日期:2020-12-04
作者简介:金文胜,男,31岁,主治医师,硕士,主要从事内分泌临床及其基础研究工作。

Effect of vanadate given by gavage on OGTT and glucoregulatory hormones in STZ-diabetic rats

JIN Wen-Sheng, ZHANG Zhong-Hui¹, ZHANG Ping¹

Department of Endocrinology, Guangzhou General Hospital of PLA.GuangZhou 510010;
¹Department of Endocrinology, South-Western Hospital of the Third Military Medical University, Chongqing 630038

Received:1999-01-18 Revised:1999-04-11 Online:1999-06-26 Published:2020-12-04

摘要/Abstract

摘要： 目的研究一定剂量的钒酸盐的降糖作用与理糖激素变化的关系。方法采用管饲法喂饲Wistar 大鼠20 mg·kg^-1·d^-1 正钒酸钠(Va) 共2 w ks, 观察口服葡萄糖耐量(OGTT)、胰岛素释放曲线、胰高血糖素(Glc)、皮质酮(Cor)、体重的变化。结果 Va 不影响正常大鼠的OGTT 和血浆Glc 和Cor 水平, 而抑制体重的增长;Va 显著改善STZ 糖尿病大鼠的OGTT, 并使升高的Glc 和Cor 正常化, 而低体重和低水平的胰岛素释放曲线无明显改善。结论提示该剂量的Va 可有效地降血糖, 纠正糖尿病糖代谢和激素紊乱, 但对体重仍有较明显的副作用。

关键词: 钒酸盐, 糖尿病, 胰高血糖素, 皮质酮

Abstract: Aim The antihy perglycemia effect of vandate in a certain do sage and the concurrent change of relevant hormones were observed.Methods Gavage method was employed to introduce sodium or thovanadate (20 mg·kg^-1·d^-1, 2 wks)into Wistar rats with or without diabetes, and oralglucose tolerance test (OGTT), glucose-induced insulin secretion curve (GIISC), body weight and serum levels of glucagon and corticosterone were detected.Results This dosage of vanadate did not exert significantly inf luence on OGTT and serum levels of glucagon and corticosterone, but inhibited maximal insulin secretion and body weight gain in normal rats.In diabetic rats, by contrast, OGTT was improved significantly and the elevated glucagon and corticosterone were reduced markedly or normalized by vanadate, but body weight and GIISC did not change significantly. Conclusion Vandate in such dosage lowers glycemia effectively, ameliorates the disorder of glucose homeostasis and glucotropic hormones, but has obvious side-effect on body weight.

Key words: vanadate, experimental diabetes mellitus, corticosterone, glucagon

中图分类号:

R977.15

金文胜, 张忠辉, 张平. 钒酸盐管饲对STZ糖尿病大鼠OGTT和理糖激素的影响[J]. 中国临床药理学与治疗学, 1999, 4(2): 93-97.

JIN Wen-Sheng, ZHANG Zhong-Hui, ZHANG Ping. Effect of vanadate given by gavage on OGTT and glucoregulatory hormones in STZ-diabetic rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 1999, 4(2): 93-97.

参考文献

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