细胞代谢组学及其应用

摘要/Abstract

摘要： 细胞代谢组学通常被定义为胞内和细胞膜小分子代谢物的集合,而代谢物参与胞内进程的多种变化,其浓度可近似地反映一个器官、组织或细胞的表型。细胞代谢组学是一个新兴发展的领域,它可解决基本的生物学问题,并允许观察细胞内的代谢现象。在后基因时代,与当前其他常用的方法相比,细胞代谢组学具有许多潜在的优势,已成为一个有前途的分析工具。现简要综述细胞代谢组学的主要研究流程及其应用、与其他组学联用等方面的研究进展。

关键词: 细胞代谢组学, 研究流程, 组学联用

Abstract: Cell metabonomics is often defined as the set of small molecule metabolites in intracellular and membrane. Metabolites are involved in a diverse range of intracellular processes, and their concentrations closely reflect the phenotype of an organism, tissue, or cell. Cell metabonomics is an emerging filed, and it can solve fundamental biological questions and is used to observe metabolic phenomena in cells. In the postgenomics era, cell metabonomics has many potential advantages compared with currently used methods, and it has become a promising analytical tools. This paper briefly reviewed the major research process of cell metabonomics and the progress in application and the integration with other omics.

Key words: cell metabonomics, research process, integration with other omics

中图分类号:

R966

姚卫峰, 周莉娜, 张丽, 丁安伟, 李伟. 细胞代谢组学及其应用[J]. 中国临床药理学与治疗学, 2014, 19(3): 334-340.

YAO Wei-feng, ZHOU Li-na, ZHANG Li, DING An-wei, LI Wei. Cell Metabonomics and its Applications[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(3): 334-340.

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