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中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (2): 180-183.doi: 10.12092/j.issn.1009-2501.2018.02.012

• 药物治疗学 • 上一篇    下一篇

米非司酮对行腹腔镜子宫内膜异位手术患者性激素及细胞因子的影响

吕红青,邵明君,胡美旭,胡 旻   

  1. 金华市中心医院妇科,金华 321000,浙江
  • 收稿日期:2017-08-06 修回日期:2017-09-06 出版日期:2018-02-26 发布日期:2018-03-02
  • 作者简介:吕红青,女,本科,主治医师,研究方向:妇科疾病临床诊治。 Tel:13958408579 E-mail:cgd0421@163.com
  • 基金资助:

    浙江省自然基金一般项目(Y13H040019)

Effects of mifepristone on sex hormones and cytokines in patients undergoing laparoscopic endometriosis

LV Hongqing, SHAO Mingjun, HU Meixu, HU Min   

  1. Department of Gynaecology, Jinhua Central Hospital, Jinhua 321000, Zhejiang, China
  • Received:2017-08-06 Revised:2017-09-06 Online:2018-02-26 Published:2018-03-02

摘要:

目的: 探讨米非司酮对行腹腔镜子宫内膜异位手术患者性激素和细胞因子的影响。方法: 选择2015年2月至2017年4月在我院行腹腔镜子宫内膜异位手术的患者90例,按照随机数字表法将其分为观察组45例和对照组45例,对照组采用单纯手术治疗,观察组在对照组的基础上口服米非司酮片,观察两组患者在治疗前和治疗6个月后性激素和细胞因子水平的变化情况。结果: 治疗6个月后,观察组显效29例,有效12例,无效4例,总有效率91.1%,对照组显效18例,有效15例,无效12例,总有效率73.3%,观察组总有效率明显高于对照组(P<0.05);治疗6个月后,两组患者雌二醇(E2)、黄体生成激素(LH)和卵泡生成激素(FSH)水平与治疗前相比均有明显降低(P<0.05),且观察组降低程度更加明显(P<0.05);治疗6个月后,两组患者肝细胞生长因子(HGF)水平均有明显降低(P<0.05),且观察组降低程度更加明显(P<0.05),两组患者血清脂联素水平均有明显升高(P<0.05),且观察组升高程度更加明显(P<0.05)。结论:米非司酮联合腹腔镜手术治疗子宫内膜异位患者的效果优于单纯应用腹腔镜手术,能够有效改善患者性激素、HGF和脂联素水平,提高临床疗效,对于临床治疗具有积极的指导意义。

关键词: 米非司酮, 腹腔镜, 子宫内膜异位, 肝细胞生长因子

Abstract:

AIM: To investigate the effects of mifepristone on sex hormones and cytokines in patients undergoing laparoscopic endometriosis. METHODS: Ninety patients who underwent laparoscopic endometriosis in our hospital from Feb. 2015 to Apr. 2017 were divided into observation group (45 cases) and control group (45 cases) according to the random number table method.The control group was treated with simple surgery, while the observation group was treated with surgery and oral mifepristone tablets. The changes of sex hormones and cytokines in the two groups before treatment and 6 months after treatment were observed. RESULTS: Six months after treatment, the curative effects were markedly effective in 29 cases, effective in 12 cases, ineffective in 4 cases in the observation group; the total effective rate was 91.1%. While the curative effects were markedly effective in 18 cases, effective in 15 cases, ineffective in 12 cases; the total effective rate was 73.3%. The total effective rate of the observation group was significantly higher than the control group (P<0.05). Six months after treatment, the levels of estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the two groups were significantly lower than those before treatment (P<0.05), and the decrease degree of the observation group was more obvious (P<0.05). Six months after treatment, the levels of hepatocyte growth factor (HGF) in two groups were significantly decreased, and the reduction of the observation group was more obvious (P<0.05). The serum adiponectin levels of two groups were significantly increased (P<0.05), and the elevation of the observation group was more obvious (P<0.05). CONCLUSION: Mifepristone combined with laparoscopic surgery in the treatment of endometriosis patients is better than the simple application of laparoscopic surgery, it can effectively improve the levels of patients' sex hormone, HGF,serum adiponectin, and clinical efficacy, and it has a positive guiding significance for clinical treatment.

Key words: mifepristone, laparoscopic, endometriosis, hepatocyte growth factor

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