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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (6): 820-827.doi: 10.12092/j.issn.1009-2501.2025.06.012

• 综述与讲座 • 上一篇    下一篇

中药有效成分调控PI3K/Akt信号通路治疗脑缺血再灌注损伤的研究进展

张译丹1，2，孙兴华3，4，曲阳4，胡晓阳1，3，张淼3，4   

  1. 1黑龙江中医药大学基础医学院，哈尔滨  150040，黑龙江；2黑龙江中医药大学附属第三医院，哈尔滨  150001，黑龙江；3黑龙江省针药结合防治重大脑病重点实验室，哈尔滨  150040，黑龙江；4黑龙江中医药大学附属第二医院，哈尔滨  150001，黑龙江

  • 收稿日期:2024-07-04 修回日期:2024-12-26 出版日期:2025-06-26 发布日期:2025-06-09
  • 通讯作者: 胡晓阳，男，博士，教授，研究方向：方剂配伍规律及药效物质基础研究。 E-mail： 3429600871@qq.com
  • 作者简介:张译丹，女，硕士，研究方向：方剂配伍规律及药效物质基础研究。 E-mail： 2630054725@qq.com
  • 基金资助:
    黑龙江省中医药管理局科研项目（ZHY2020-026）；黑龙江省教育厅“双一流”学科协同创新成果建设项目（15041230008）；科技部重大新药创制“科技重大专项”-示范性新药临床评价技术平台建设（2018ZX09734-002-004）

Research progress on the regulation of PI3K/Akt signaling pathway by active ingredients of traditional Chinese medicine in the treatment of cerebral ischemia-reperfusion injury

ZHANG Yidan1,2, SUN Xinghua3,4, QU Yang4, HU Xiaoyang1,3, ZHANG Miao3,4   

  1. 1Basic Medical College of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang, China; 2The Third Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001, Heilongjiang, China; 3Key Laboratory of Acupuncture combined with Medicine for the Prevention and Treatment of Major Brain Diseases in Heilongjiang Province, Harbin 150040, Heilongjiang, China; 4The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001, Heilongjiang, China
  • Received:2024-07-04 Revised:2024-12-26 Online:2025-06-26 Published:2025-06-09

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摘要：

脑缺血再灌注损伤（cerebral ischemia reperfusion injury，CIRI）可通过离子失衡、炎症、线粒体功能障碍、氧化应激和血管通透性增强等复杂的病理过程导致继发性脑损伤，严重影响缺血性脑卒中（cerebral ischemic stroke，CIS）患者预后和生活质量，如何有效减少和防治CIRI所致的神经损伤成为对CIS研究的重点和热点。近年来，许多研究已经证实了中药有效成分可以通过磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶（phosphatei-dylinositol 3 kinase/serine-threonine kinase，PI3K/Akt）信号通路减轻氧化应激，抑制自噬，调节细胞凋亡，控制神经炎症，降低细胞焦亡指数，缓解神经元组织病理形态学损伤，促进神经元存活，增强突触可塑性，发挥治疗CIRI的作用。基于此，本文就PI3K/Akt信号通路及其对CIRI的作用以及中药有效成分调控PI3K/Akt信号治疗CIRI的研究进行综述，以期为中药有效成分用于临床减轻CIRI损伤提供理论依据。

关键词: 脑缺血再灌注损伤, 中药, 有效成分, 磷脂酰肌醇-3-激酶/丝苏氨酸蛋白激酶, 研究进展

Abstract:

Cerebral ischemia-reperfusion injury can lead to secondary brain damage through complex pathological processes such as ion imbalance, inflammation, mitochondrial dysfunction, oxidative stress, and increased vascular permeability, seriously affecting the prognosis and quality of life of ischemic stroke patients. How to effectively reduce and prevent neurological damage caused by CIRI has become a key and hot topic in CIS research. In recent years, many studies have confirmed that the active ingredients of traditional Chinese medicine can alleviate oxidative stress, inhibit autophagy, regulate cell apoptosis, control neuroinflammation, reduce cell apoptosis index, alleviate neuronal histopathological damage, promote neuronal survival, enhance synaptic plasticity, and play a therapeutic role in CIRI through the PI3K/Akt signaling pathway. In summary, this article provides a review of the PI3K/Akt signaling pathway and its role in CIRI, as well as the research on the regulation of PI3K/Akt signaling by active ingredients in traditional Chinese medicine for the treatment of CIRI. The aim is to provide a theoretical basis for the clinical use of active ingredients in traditional Chinese medicine to alleviate CIRI damage.

Key words: cerebral Ischemia-reperfusion injury, traditional Chinese medicine, active ingredient, PI3K/Akt, research progress

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