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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (9): 1253-1259.doi: 10.12092/j.issn.1009-2501.2025.09.012

• 综述与讲座 • 上一篇    下一篇

上皮细胞和巨噬细胞相互作用在肺部疾病中的研究进展

李蒙雨1,2，江伟2，张亚飞2，潘欣2，王媛媛2,1   

  1. 1安徽医科大学药学院，合肥  230032，安徽；2安徽医科大学第二附属医院药学部，合肥  230601，安徽
  • 收稿日期:2024-01-29 修回日期:2024-03-13 出版日期:2025-09-26 发布日期:2025-09-09
  • 通讯作者: 王媛媛，女，博士，主任药师，副教授，硕士生导师，研究方向：肺脏药理学。 E-mail： wangyuanyuan@ahmu.edu.cn
  • 作者简介:李蒙雨，男，硕士研究生，研究方向：肺脏药理学。 E-mail： mengyulilmy@163.com
  • 基金资助:
    安徽省卫生健康科研项目（AHWJ2023BAc10009）；2022年度安徽省高校自然科学基金重点项目（2022AH050773） 

Research progress on the interaction between epithelial cells and macrophages in lung diseases

LI Mengyu1,2, JIANG Wei2, ZHANG Yafei2, PAN Xin2, WANG Yuanyuan2,1   

  1. 1School of Pharmacy, Anhui Medical University, Hefei 230032, Anhui, China; 2Department of Pharmacy, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China
  • Received:2024-01-29 Revised:2024-03-13 Online:2025-09-26 Published:2025-09-09

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摘要：

在肺部疾病发展过程中，肺部的上皮细胞与巨噬细胞的相互作用可发挥免疫防御、调节炎症、促进组织修复与再生等功能。当二者之间的相互作用失衡时，可导致多种肺病的发生。在特发性肺纤维化、慢性阻塞性肺病及肺癌中，受激活的上皮细胞可释放细胞因子招募并激活巨噬细胞聚集于病灶，巨噬细胞则可通过分泌细胞因子作用于上皮细胞，促进病程进展，形成正反馈循环。因此，深入探究上皮细胞与巨噬细胞在不同肺病中的相互作用，可为疾病治疗提供潜在靶点和新思路。本文拟对上皮细胞和巨噬细胞在特发性肺纤维化、慢性阻塞性肺病及肺癌中相互作用的机制与功能进行综述，以期为肺部疾病的治疗提供新的研究思路。

关键词: 上皮细胞, 巨噬细胞, 相互作用, 特发性肺纤维化, 慢性阻塞性肺病, 肺癌

Abstract:

The interaction between epithelial cells and macrophages plays a crucial role in the progression of lung diseases, including immune defense, inflammation regulation, tissue repair, and regeneration. However, an imbalance in this interaction can contribute to the development of various lung diseases. In idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and lung cancer, macrophages can promote disease progression by secreting cytokines that act on epithelial cells. Simultaneously, activated epithelial cells release cytokines to recruit and activate more macrophages in a positive feedback loop. Thus, comprehensive studies of the interactions between epithelial cells and macrophages in various lung diseases have the potential to identify new therapeutic targets and develop innovative strategies for disease management. This review aims to summarize the current knowledge regarding the interaction between epithelial cells and macrophages in idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, and lung cancer, with the goal of inspiring new research directions for the treatment of lung diseases.

Key words: epithelial cell, macrophage, interaction, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, lung cancer

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