骨科手术患者术后睡眠障碍的研究进展

doi:10.12092/j.issn.1009-2501.2026.02.016

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (2): 281-288.doi: 10.12092/j.issn.1009-2501.2026.02.016

• 综述与讲座 • 上一篇

骨科手术患者术后睡眠障碍的研究进展

赵雯昕¹^,²(), 熊兴宇¹^,², 谭雯¹^,², 汪媛媛¹^,², 孙正秀¹^,², 林永傲¹^,², 刘鹤³^,⁴^,⁵^,*(), 曹君利¹^,²^,*()

1. 徐州医科大学附属医院麻醉科，徐州 221002，江苏
2. 徐州医科大学国家药品监督管理局麻醉精神药物研究与评价重点实验室 & 江苏省麻醉学重点实验室 & 江苏省麻醉与镇痛应用技术重点实验室，徐州 221002，江苏
3. 浙江中医药大学第五临床医学院 & 湖州师范学院附属中心医院麻醉科，湖州 313003，浙江
4. 浙江中医药大学第五临床医学院 & 湖州师范学院附属中心医院麻醉与围术期临床医学研究中心，湖州 313003，浙江
5. 浙江中医药大学第五临床医学院 & 湖州师范学院附属中心医院麻醉与镇痛应用技术重点实验室，湖州 313003，浙江

收稿日期:2025-01-15 修回日期:2025-06-09 出版日期:2026-02-26 发布日期:2026-03-17
通讯作者: 刘鹤,曹君利 E-mail:1926252911@qq.com;lh121061@163.com;caojl0310@aliyun.com
作者简介:赵雯昕，女，硕士研究生，研究方向：临床麻醉技能培训与研究。E-mail：1926252911@qq.com
基金资助:
国家重点研发计划科技创新2030（2021ZD0203100）；国家自然科学基金项目（82171227）；浙江省自然科学基金探索项目/探索一般（LY22H090019）

Research progress on postoperative sleep disorders in orthopedic surgery patients

Wenxin ZHAO¹^,²(), Xingyu XIONG¹^,², Wen TAN¹^,², Yuanyuan WANG¹^,², Zhengxiu SUN¹^,², Yongao LIN¹^,², He LIU³^,⁴^,⁵^,*(), Junli CAO¹^,²^,*()

1. Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China
2. NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs & Jiangsu Province Key Laboratory of Anesthesiology & Jiangsu Key Laboratory of Applied Technology of Anesthesia and Analgesia, Xuzhou MedicalUniversity, Xuzhou 221002, Jiangsu, China
3. Department of Anesthesiology, Huzhou Central Hospital & The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University & Affiliated Central Hospital Huzhou University, Huzhou 313003, Zhejiang, China
4. Anaesthesia and Perioperative Clinical Medical Research Center, Huzhou Central Hospital & The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University & Affiliated Central Hospital Huzhou University, Huzhou 313003, Zhejiang, China
5. Key Laboratory of Applied Technology of Anesthesia and Analgesia, Huzhou Central Hospital & The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University & Affiliated Central Hospital Huzhou University, Huzhou 313003, Zhejiang, China

Received:2025-01-15 Revised:2025-06-09 Online:2026-02-26 Published:2026-03-17
Contact: He LIU,Junli CAO E-mail:1926252911@qq.com;lh121061@163.com;caojl0310@aliyun.com

摘要/Abstract

摘要：

睡眠是一种自然的周期性生理现象，对人体具有极其深远的意义。术后良好的睡眠质量不仅能促进机体修复和维持生理平衡，还能在改善认知功能、调节情绪以及加速术后恢复等多个方面起到无可替代的作用。然而，手术患者普遍存在术后睡眠质量下降的问题，这种情况在骨科手术患者中尤为突出。本文以促进骨科手术患者术后康复为目的，以术后睡眠质量问题为切入点，从术后睡眠障碍的流行病学、发生机制、危险因素、对骨科手术患者预后的影响及防治措施等方面进行综述，为临床术后睡眠障碍的预防提供新思路和临床实践参考。

关键词: 骨科手术, 术后管理, 睡眠, 术后睡眠障碍, 术后康复

Abstract:

Sleep is a natural cyclical physiological phenomenon with profound implications for the human body. Adequate postoperative sleep quality not only promotes bodily repair and maintains physiological balance but also plays an irreplaceable role in improving cognitive function, regulating emotions, and expediting postoperative recovery. However, postoperative patients commonly experience a decline in sleep quality, particularly prevalent among orthopedic surgery patients. This article aims to facilitate the postoperative recovery of orthopedic surgery patients by addressing postoperative sleep quality issues. It provides a comprehensive review of the epidemiology, mechanisms, risk factors, impact on prognosis, and prevention and treatment measures of postoperative sleep disorders in orthopedic surgery patients, offering new insights and clinical practice references for preventing postoperative sleep disorders.

Key words: orthopedic surgery, postoperative management, sleep, postoperative sleep disorders, postoperative rehabilitation

中图分类号:

赵雯昕, 熊兴宇, 谭雯, 汪媛媛, 孙正秀, 林永傲, 刘鹤, 曹君利. 骨科手术患者术后睡眠障碍的研究进展[J]. 中国临床药理学与治疗学, 2026, 31(2): 281-288.

Wenxin ZHAO, Xingyu XIONG, Wen TAN, Yuanyuan WANG, Zhengxiu SUN, Yongao LIN, He LIU, Junli CAO. Research progress on postoperative sleep disorders in orthopedic surgery patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(2): 281-288.

图/表 2

参考文献 47

1	王恒, 万小健. 全身麻醉后睡眠障碍的研究进展[J]. 国际麻醉学与复苏杂志, 2022, 43 (12): 1316- 1322. doi: 10.3760/cma.j.cn321761-20211028-00703
2	江艳滨. 120例骨科患者术后失眠的护理[J]. 中国医药指南, 2008, 6 (15): 216- 217. doi: 10.3969/j.issn.1671-8194.2008.15.160
3	中华医学会外科学分会, 中华医学会麻醉学分会. 中国加速康复外科临床实践指南(2021)(一)[J]. 协和医学杂志, 2021, 12 (5): 624- 631.
4	Ellis BW, Dudley HAF. Some aspects of sleep research in surgical stress[J]. J Psychosom Res, 1976, 20 (4): 303- 308. doi: 10.1016/0022-3999(76)90081-7
5	Oros M, Baranga L, Gutu-Robu M, et al. Sleep breathing disorders and orthopedic spinal surgery: the importance of a multidisciplinary approach[J]. Sleep Med, 2022, 100, S275. doi: 10.1016/j.sleep.2022.05.742
6	Purcell KF, Scarcella N, Chun D, et al. Treating sleep disorders after total hip and total knee arthroplasty[J]. Orthop Clin North Am, 2023, 54 (4): 397- 405. doi: 10.1016/j.ocl.2023.05.008
7	Dai Y, Shi K, Liu Q, et al. Intraoperative sleep spindle activity and postoperative sleep disturbance in elderly patients undergoing orthopedic surgery: A prospective cohort study[J]. Nat Sci Sleep, 2024, 16, 2083- 2097. doi: 10.2147/NSS.S486625
8	Putilov AA. Can the brain's thermostatic mechanism generate sleep-wake and NREM-REM sleep cycles? A nested doll model of sleep-regulating processes[J]. Clocks Sleep, 2024, 6 (1): 97- 113. doi: 10.3390/clockssleep6010008
9	Schwartz MD, Kilduff TS. The Neurobiology of sleep and wakefulness[J]. Psychiatr Clin North Am, 2015, 38 (4): 615- 644. doi: 10.1016/j.psc.2015.07.002
10	Peng W, Wu Z, Song K, et al. Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons[J]. Science, 2020, 369 (6508): eabb0556. doi: 10.1126/science.abb0556
11	Jones BE. Arousal and sleep circuits[J]. Neuropsychopharmacology, 2020, 45 (1): 6- 20. doi: 10.1038/s41386-019-0444-2
12	Mullen PE, Linsell CR, Parker D. Influence of sleep disruption and calorie restriction on biological markers for depression[J]. Lancet, 1986, 2 (8515): 1051- 1055. doi: 10.1016/s0140-6736(86)92024-6
13	Varallo G, Giusti EM, Manna C, et al. Sleep disturbances and sleep disorders as risk factors for chronic postsurgical pain: A systematic review and meta-analysis[J]. Sleep Med Rev, 2022, 63, 101630. doi: 10.1016/j.smrv.2022.101630
14	Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease[J]. Physiol Rev, 2019, 99 (3): 1325- 1380. doi: 10.1152/physrev.00010.2018
15	Zielinski MR, Gibbons AJ. Neuroinflammation, sleep, and circadian rhythms[J]. Front Cell Infect Microbiol, 2022, 12, 853096. doi: 10.3389/fcimb.2022.853096
16	Dai Z, Cheng X, Chen F. Effect of comprehensive noise reduction management on the postoperative negative emotion, stress response hormone and sleep status of burn patients: Single-centre retrospective analysis[J]. Noise Health, 2024, 26 (122): 410- 416. doi: 10.4103/nah.nah_80_24
17	Morris G, Stubbs B, Köhler CA, et al. The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis[J]. Sleep Med Rev, 2018, 41, 255- 265. doi: 10.1016/j.smrv.2018.03.007
18	Coulson RL, Mourrain P, Wang GX. Sleep deficiency as a driver of cellular stress and damage in neurological disorders[J]. Sleep Med Rev, 2022, 63, 101616. doi: 10.1016/j.smrv.2022.101616
19	Ye F, Wei C, Wu A. The potential mechanism of mitochondrial homeostasis in postoperative neurocognitive disorders: An in-depth review[J]. Ann Med, 2024, 56 (1): 2411012. doi: 10.1080/07853890.2024.2411012
20	Ohayon MM, Carskadon MA, Guilleminault C, et al. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan[J]. Sleep, 2004, 27 (7): 1255- 1273. doi: 10.1093/sleep/27.7.1255
21	Fan Y, Yang T, Liu Y, et al. Nomogram for predicting the risk of postoperative delirium in elderly patients undergoing orthopedic surgery[J]. Perioper Med (Lond), 2024, 13 (1): 34. doi: 10.1186/s13741-024-00393-9
22	Han SB, Kim SB, Shin KH. Risk factors for postoperative pneumonia in patients undergoing hip fracture surgery: a systematic review and meta-analysis[J]. BMC Musculoskelet Disord, 2022, 23 (1): 553. doi: 10.1186/s12891-022-05497-1
23	Tran D, Tang C, Tabatabai S, et al. The impact of surgery duration and surgery end time on postoperative sleep in older adults[J]. J Sleep Disord Manag, 2021, 7 (2): 34. doi: 10.23937/2572-4053.1510034
24	Rosenberg-Adamsen S, Kehlet H, Dodds C, et al. Postoperative sleep disturbances: mechanisms and clinical implications[J]. Br J Anaesth, 1996, 76 (4): 552- 559. doi: 10.1093/bja/76.4.552
25	Cho A. A randomized trial examining preoperative sedative medication and post-operative sleep in children Christopher[J]. Physiol Behav, 2016, 176 (1): 100- 106. doi: 10.1016/j.jclinane.2015.11.011
26	Bonafide CP, Aucutt-Walter N, Divittore N, et al. Remifentanil inhibits rapid eye movement sleep but not the nocturnal melatonin surge in humans[J]. Anesthesiology, 2008, 108 (4): 627- 633. doi: 10.3410/f.1108369.565109
27	Zhang JF, Williams JP, Zhao QN, et al. Multimodal sleep, an innovation for treating chronic insomnia: case report and literature review[J]. J Clin Sleep Med, 2021, 17 (8): 1737- 1742. doi: 10.5664/jcsm.9310
28	Pu J, Guo C, Xiao Y, et al. Effect of general anesthesia combined with transversus abdominis plane block on postoperative sleep disorders in elderly patients undergoing gastrointestinal tumor surgery: A prospective, randomized controlled trial[J]. Nat Sci Sleep, 2025, 17, 17- 25. doi: 10.2147/NSS.S486711
29	Su X, Wang DX. Improve postoperative sleep: What can we do[J]. Curr Opin Anaesthesiol, 2018, 31 (1): 83- 88. doi: 10.1097/ACO.0000000000000538
30	Mashour GA, Hudetz AG. Bottom-up and top-down mechanisms of general anesthetics modulate different dimensions of consciousness[J]. Front Neural Circuits, 2017, 11, 44. doi: 10.3389/fncir.2017.00044
31	Song B, Zhu J. Cerebellar malfunction and postoperative sleep disturbances after general anesthesia: a narrative review[J]. Sleep Breath, 2022, 26 (1): 31- 36. doi: 10.1007/s11325-021-02361-9
32	Navarro-Ledesma S, Hamed-Hamed D, Gonzalez-Muñoz A, et al. Impact of physical therapy techniques and common interventions on sleep quality in patients with chronic pain: A systematic review[J]. Sleep Med Rev, 2024, 76, 101937. doi: 10.1016/j.smrv.2024.101937
33	王悠华. 老年冠心病住院患者睡眠障碍的原因分析与护理干预对策研究[J]. 世界睡眠医学杂志, 2021, 8 (4): 561- 562. doi: 10.3969/j.issn.2095-7130.2021.04.002
34	乔亚婷, 刘佩华, 于辉. 超前镇痛联合多模式镇痛在髋关节置换术后康复中的应用价值[J]. 临床医学研究与实践, 2022, 7 (32): 169- 171. doi: 10.19347/j.cnki.2096-1413.202232048
35	Chen H, Fang Z, Wu YY, et al. Association between perioperative self-reported sleep disturbances and delirium risk in elderly patients following total joint arthroplasty: a cohort study[J]. J Sleep Res, 2024, 33 (5): e14168. doi: 10.1111/jsr.14168
36	Xu X, Liang W, Tang J, et al. New-onset sleep disorders before cardiac surgery may indicate an increased risk of postoperative atrial fibrillation[J]. Ann Thorac Cardiovasc Surg, 2023, 29 (6): 287- 293. doi: 10.5761/atcs.oa.23-00074
37	王法欣, 王福茹, 宋保华. 睡眠不足对代谢和内分泌功能的影响[J]. 国外医学. 护理学分册, 2000 (4): 168.
38	封艳辉. 睡眠缺乏影响骨质健康及骨髓功能[J]. 山东医药, 2012, 52 (36): 101.
39	Yu S, Xiong Y, Lu G, et al. Effects of preoperative sleep disorders on anesthesia recovery and postoperative pain in patients undergoing laparoscopic gynecological surgery under general anesthesia[J]. Mediators Inflamm, 2022, 2022, 7998104. doi: 10.1155/2022/7998104
40	Yue JL, Chang XW, Zheng JW, et al. Efficacy and tolerability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis[J]. Sleep Med Rev, 2023, 68, 101746. doi: 10.1016/j.smrv.2023.101746
41	Fang J, Yang J, Xie Y. Effects of short-term preoperative intranasal dexmedetomidine plus conventional treatment on delirium following cardiac surgery in patients with sleep disorders[J]. Perioper Med (Lond), 2024, 13 (1): 17. doi: 10.1186/s13741-024-00371-1
42	De Crescenzo F, D'Alò GL, Ostinelli EG, et al. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis[J]. Lancet, 2022, 400 (10347): 170- 184. doi: 10.1016/S0140-6736(22)00878-9
43	Mysliwiec V, Martin JL, Ulmer CS, et al. The Management of chronic insomnia disorder and obstructive sleep apnea: Synopsis of the 2019 U. S. Department of Veterans Affairs and U. S. Department of Defense Clinical Practice Guidelines[J]. Ann Intern Med, 2020, 172 (5): 325- 336. doi: 10.7326/M19-3575
44	杨杰, 曹君利, 刘鹤. 无创神经调控技术对全麻患者术后睡眠功能紊乱影响的研究进展[J]. 中国临床药理学与治疗学, 2022, 27 (12): 1322- 1332. doi: 10.12092/j.issn.1009-2501.2022.12.001
45	龚珏如, 唐玲. 睡眠障碍物理治疗的研究进展[J]. 中国当代医药, 2023, 30 (10): 48- 53. doi: 10.3760/cma.j.cn101070-20221123-01321
46	Song B, Chang Y, Li Y, et al. Effects of transcutaneous electrical acupoint stimulation on the postoperative sleep quality and pain of patients after video-assisted thoracoscopic surgery: a prospective, randomized controlled trial[J]. Nat Sci Sleep, 2020, 12, 809- 819. doi: 10.2147/NSS.S270739
47	Hertenstein E, Trinca E, Wunderlin M, et al. Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis[J]. Sleep Med Rev, 2022, 62, 101597. doi: 10.1016/j.smrv.2022.101597

技术设备	经颅磁刺激（TMS）	经皮耳迷走神经刺激（taVNS）	经颅直流电刺激（tDCS）	经皮穴位电刺激（TEAS）
原理	电磁感应原理：通过外部的电磁场使大脑中能够产生与之感应的电场，改善脑血液循环，对内源性神经递质的代谢产生影响	迷走神经刺激：经孤束核传导，广泛影响大脑的各个部分，包括丘脑、小脑、眼窝前额皮质、边缘系统、下丘脑和髓质	直流电：调节神经元静息膜电位，阳极刺激导致神经元静息膜电位去极化，起兴奋作用；阴极刺激通过超极化抑制皮层兴奋性	通过电流刺激体表特定穴位，广泛激活躯体感觉与运动区
作用方式	电磁系统形成颅内电流	低强度电流	低强度（一般为1～2 mA）直流电	低强度电流
作用位置	左、右侧背外侧前额叶皮质	左、右耳甲艇部	阳极位于左侧背外侧前额叶皮层上方，阴极位于右侧眶上区域上方	涌泉穴、三阴交穴、神门穴、内关穴等
刺激模式	低频刺激（≤1 Hz）	密集波，脉冲频率4～20 Hz，强度0.8～12 mA，低于患者的最大耐受性	强度0.5～2 mA，低于患者的最大耐受性	疏密频率采用 2/100 Hz，强度 6～10 mA，低于患者的最大耐受性
时间频率	每日1次，每次20～30 min，连续2～4周不等	每日1～2次，每次30 min，每周至少5 d，共持续4周	每日1次，每次20～ 30 min	每日1次，每次30 min，持续3～5 d
作用结果	抑制患者脑干上行网状激动系统功能，使诱导慢波睡眠出现，加深睡眠深度	降低内侧前额叶皮层与其他大脑区域的功能连接，缩短入睡时间、延长睡眠时间	改变脑电图节律，增强睡眠时的慢波活动	血浆褪黑素含量增加，睡眠质量明显提升
不良反应	电磁干扰、夜间多梦等	心率减慢、耳鸣等	暂时性头痛、电极下皮肤瘙痒等	皮肤烧灼感、过敏反应等

技术设备	经颅磁刺激（TMS）	经皮耳迷走神经刺激（taVNS）	经颅直流电刺激（tDCS）	经皮穴位电刺激（TEAS）
原理	电磁感应原理：通过外部的电磁场使大脑中能够产生与之感应的电场，改善脑血液循环，对内源性神经递质的代谢产生影响	迷走神经刺激：经孤束核传导，广泛影响大脑的各个部分，包括丘脑、小脑、眼窝前额皮质、边缘系统、下丘脑和髓质	直流电：调节神经元静息膜电位，阳极刺激导致神经元静息膜电位去极化，起兴奋作用；阴极刺激通过超极化抑制皮层兴奋性	通过电流刺激体表特定穴位，广泛激活躯体感觉与运动区
作用方式	电磁系统形成颅内电流	低强度电流	低强度（一般为1～2 mA）直流电	低强度电流
作用位置	左、右侧背外侧前额叶皮质	左、右耳甲艇部	阳极位于左侧背外侧前额叶皮层上方，阴极位于右侧眶上区域上方	涌泉穴、三阴交穴、神门穴、内关穴等
刺激模式	低频刺激（≤1 Hz）	密集波，脉冲频率4～20 Hz，强度0.8～12 mA，低于患者的最大耐受性	强度0.5～2 mA，低于患者的最大耐受性	疏密频率采用 2/100 Hz，强度 6～10 mA，低于患者的最大耐受性
时间频率	每日1次，每次20～30 min，连续2～4周不等	每日1～2次，每次30 min，每周至少5 d，共持续4周	每日1次，每次20～ 30 min	每日1次，每次30 min，持续3～5 d
作用结果	抑制患者脑干上行网状激动系统功能，使诱导慢波睡眠出现，加深睡眠深度	降低内侧前额叶皮层与其他大脑区域的功能连接，缩短入睡时间、延长睡眠时间	改变脑电图节律，增强睡眠时的慢波活动	血浆褪黑素含量增加，睡眠质量明显提升
不良反应	电磁干扰、夜间多梦等	心率减慢、耳鸣等	暂时性头痛、电极下皮肤瘙痒等	皮肤烧灼感、过敏反应等

[1]	翟菲菲, 黄颜. 睡眠相关过度运动性癫痫诊疗进展[J]. 中国临床药理学与治疗学, 2026, 31(2): 168-174.
[2]	严婧, 罗爱林, 李世勇. 阻塞性睡眠呼吸暂停患者上气道手术围手术期管理研究进展[J]. 中国临床药理学与治疗学, 2026, 31(2): 265-271.
[3]	李庆云, 黄珂. 日间过度思睡病因及诊疗现状[J]. 中国临床药理学与治疗学, 2025, 30(12): 1587-1595.
[4]	王赞, 王瑞琦, 张亚男, 蔡李佳, 孙晴晴. 前沿探索：觉醒调控机制新进展及其对新药开发的启示[J]. 中国临床药理学与治疗学, 2025, 30(12): 1596-1605.
[5]	吴惠涓, 赵忠新. 促觉醒药物的研发：过去、现在与未来[J]. 中国临床药理学与治疗学, 2025, 30(12): 1606-1614.
[6]	欧琼, 周若菡, 蔡洧丹. 促觉醒药物用于阻塞性睡眠呼吸暂停残余日间过度思睡的进展[J]. 中国临床药理学与治疗学, 2025, 30(12): 1625-1631.
[7]	张斌, 辛倩倩, 黄豪康. 多巴胺去甲肾上腺素再摄取抑制剂治疗日间过度思睡研究进展[J]. 中国临床药理学与治疗学, 2025, 30(12): 1632-1639.
[8]	何超, 罗心为, 于清崧, 李亚东. 食欲素调控睡眠-觉醒周期的神经环路机制[J]. 中国临床药理学与治疗学, 2025, 30(11): 1443-1452.
[9]	寇梁, 夏昀, 王涛. 失眠障碍的发生机制和药物干预策略[J]. 中国临床药理学与治疗学, 2025, 30(11): 1479-1490.
[10]	孙静梓, 刘维英, 胡澳燕, 鲍八虎, 叶育才, 陈国荣. 阿片类药物对阻塞性睡眠呼吸暂停的影响研究进展[J]. 中国临床药理学与治疗学, 2025, 30(1): 125-130.
[11]	陈思蕊, 李军强, 党小利, 王天成. 吡仑帕奈在癫痫共病治疗中的研究进展[J]. 中国临床药理学与治疗学, 2024, 29(3): 354-360.
[12]	武兴东, 岳红梅, 朱浩斌, 刘苗苗, 李雅亭, 许金回. 药物治疗阻塞性睡眠呼吸暂停的研究进展[J]. 中国临床药理学与治疗学, 2024, 29(2): 215-229.
[13]	许金回, 岳红梅, 李雅亭, 刘苗苗, 武兴东, 朱浩斌. 间充质干细胞对OSAHS病理生理调节机制的研究进展[J]. 中国临床药理学与治疗学, 2024, 29(1): 114-120.
[14]	王娟, 刘维英, 叶育才, 付文丽, 张莎, 李乐萍. 去甲肾上腺素再摄取抑制剂联合抗毒蕈碱剂治疗阻塞性睡眠呼吸暂停的研究进展[J]. 中国临床药理学与治疗学, 2023, 28(6): 714-720.
[15]	顾芸菲, 陈苏衡, 于恺华, 鲍振星, 李玉兰. 丘脑室旁核在全身麻醉和睡眠觉醒神经通路中的作用[J]. 中国临床药理学与治疗学, 2023, 28(12): 1436-1440.

骨科手术患者术后睡眠障碍的研究进展

Research progress on postoperative sleep disorders in orthopedic surgery patients

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 2

参考文献 47

相关文章 15

编辑推荐

Metrics

本文评价