Abstract:

AIM: To investigate the effects of mifepristone on sex hormones and cytokines in patients undergoing laparoscopic endometriosis. METHODS: Ninety patients who underwent laparoscopic endometriosis in our hospital from Feb. 2015 to Apr. 2017 were divided into observation group (45 cases) and control group (45 cases) according to the random number table method.The control group was treated with simple surgery, while the observation group was treated with surgery and oral mifepristone tablets. The changes of sex hormones and cytokines in the two groups before treatment and 6 months after treatment were observed. RESULTS: Six months after treatment, the curative effects were markedly effective in 29 cases, effective in 12 cases, ineffective in 4 cases in the observation group; the total effective rate was 91.1%. While the curative effects were markedly effective in 18 cases, effective in 15 cases, ineffective in 12 cases; the total effective rate was 73.3%. The total effective rate of the observation group was significantly higher than the control group (P<0.05). Six months after treatment, the levels of estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the two groups were significantly lower than those before treatment (P<0.05), and the decrease degree of the observation group was more obvious (P<0.05). Six months after treatment, the levels of hepatocyte growth factor (HGF) in two groups were significantly decreased, and the reduction of the observation group was more obvious (P<0.05). The serum adiponectin levels of two groups were significantly increased (P<0.05), and the elevation of the observation group was more obvious (P<0.05). CONCLUSION: Mifepristone combined with laparoscopic surgery in the treatment of endometriosis patients is better than the simple application of laparoscopic surgery, it can effectively improve the levels of patients' sex hormone, HGF,serum adiponectin, and clinical efficacy, and it has a positive guiding significance for clinical treatment.

Key words: mifepristone, laparoscopic, endometriosis, hepatocyte growth factor