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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2022, Vol. 27 ›› Issue (8): 886-891.doi: 10.12092/j.issn.1009-2501.2022.08.007

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Research progress on the role and mechanism of irisin in organ ischemia/reperfusion injury

HAN Xiaoxia1, LENG Yufang1,2, LV Xingjiao1, HOU Xiaoyu1, CAO Xuefen1, Janvier NIBARUTA1   

  1. 1First Medical College of Lanzhou University, Lanzhou 730000, Gansu, China; 2Department of Anesthesiology, First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China
  • Received:2022-03-25 Revised:2022-05-17 Online:2022-08-26 Published:2022-09-13

Abstract: Irisin is an endogenous secreted muscle factor, which not only plays a certain clinical application value in a variety of metabolic diseases, cardiovascular and cerebrovascular diseases, neurological diseases, tumors and other diseases, but also affects the occurrence and development of organ ischemia/reperfusion injury. In this paper, the role and mechanism of irisin in organ ischemia/reperfusion injury were summarized, aiming to provide new ideas for prevention and treatment of organ ischemia/reperfusion injury.

Key words: irisin, organ ischemia/reperfusion, function, mechanism

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