Abstract: Aim To compare the effects of different doses of simvastatin on decreasing blood-lipoids. Methods Forty-t hree patients were randomly divided into group A and B.In group A, the initial dose of simvastat in was 5 mg/d and was increased to 10mg/d if there was st ill a high level of blood-lipoids after 12 weeks thrapy.In group B, the ini tial dose of simvastat in was 10 mg/d and then the dose was increased to 20 mg/d if no good result was obtained.Results In group A, as compared with the previous level, the TC and LDL-C decreased 10.4% and 15.4% respectively.Only in 27.3% of the patients the TC decreased to normal, but none of themgot to the optimal result.The LDL-C in 9.1%o f the patients decreased to normal and in 4.5% to the optimal level.By increasing the dose to 10 mg/ d, the TC and LDL-C decreased 24.6% and 26.3% respectively and in 50% of the patients the TC level decreased to normal.The TC level in 36.4% and LDL-C level in 22.7% of the patients were optimal.In group B, the TC in 80.9% and LDL-C in 66.7% of the patients decreased to normal and TC in 76.2% and LDL-C in 80.9% of the reached a reasonable level.Conclusion Thereasonable do sage of simvastatin should be 20 mg/d, which could decrease the blood-lipoids in majority of the patients to optimal level.

Key words: simvastatin, blood-lipoids