Abstract: Aim The antihypertensive effect of laminine was studied in renal hypertensive rat models.Methods The lef t kidney was wrapped by nylon fabrics and the right kidney was removed under anesthesia to set up the hy pe rtensive rat model.The systolic blood pressure was measured by the tail method.Laminine 150 and 300 mg/(kg·d)were given orally to hypertensive rats in low dose group and high dose group respectively for 20 days, and nifendipine 10 mg/kg·d as positive control, NS as negative control.The hypotensive effects were observed on the thi rd and seventh day after the administ ration of laminine.Results after 20 days, the systolic blood pressure of rats was lowered by 20.2% in low dose group 20.2% and by 26.4% in high dose group respectively, in comparison with negative control, there were significant differences (P<0.01).Conclusion Theresults showed that laminine had hypotensive effects.

Key words: laminine, renal hypertension, hypotensive effect, rat