Inhibition of resveratral on lipid peroxidativereaction and reactive oxygen species of early experimental rat spinal cordinjury

Abstract

Abstract: AIM: To study the effects of resveratral on lipid peroxidativereaction and reactive oxygen species (ROS) in experimental spinal cordinjury rats.METHODS: The weight-dropping method was used to produce the experimental spinal cordinjury (SCI) in adultrats. Resveratrol (Res) and methylprednisolone (MPSS) were given intraperitoneally by the bolus injections of 50, 100mg·kg^-1 and 100 mg·kg^-1, respectively, immediately after induction of SCI.And then the effects of Res were observed at 1, 24, 48 h after SCI compared with MPSS.RESULTS: Res could obvious prevented reduction of superoxide dismutase (SOD) activity and reduce malondialdehyde (MDA) production andinhibit the ROS level in the injured spinal cord tissue in comparison with the SCI model at the dose of 50 mg·kg^-1 and 100 mg·kg^-1, which the mostremarkable effects was at 48 h with the inhibition rate over 40 %.The effects of Res were the sameas or even greater than those of MPSS.CONCLUSION: Res may effectively protect the spinal cord from lipid peroxidativereaction and ROS damage in SCI.

Key words: resveratrol, spinal cordinjury(SCI), superoxide dismutase(SOD), malondialdehyde(MDA), reactive oxygen species(ROS)

CLC Number:

R962
R453.9

CAO Cheng-Xi, HE You-Zhao, ZHOU Shu-Lin, QIAN Yi-Tai. Inhibition of resveratral on lipid peroxidativereaction and reactive oxygen species of early experimental rat spinal cordinjury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2002, 7(3): 193-196.

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