Abstract: AIM: To compare the efficacy and side effects between stronger Neo-Minophagen C(SNMC) and caryophyllin. METHODS: 87 patients were randomly divided into two groups.44 patients as a treatment group orally received 250 ml 5% glucose and 100 ml SNMC orally once a day for 1 month.Then the dose of SNMC changed to 50mg, tid for 2months.43 patients as a control group were given caryophyllin 4ml·d ^-1 for 3 months. RESULTS: After completion of therapy, the clinical syndromes and the liver function of the treatment group were much better than that of control group.The general effective rate was 90.9% in treatment group and 55.8% in control group (P <0.05).Side effects were not found. CONCLUSION: SNMC is effective agent in treatment of patients with chronic hepatitis B.

Key words: pharmacodynamics, SNMC, caryophyllin, chronic hepatitis b, side effects