Abstract: AIM: To investigate the anticancer effects and toxicity of cisplatin and cyclophosphamide used alone and in combination in treatment of the mice models with sarcoma 180 (S₁₈₀).METHODS: The anticancer effects and toxicity were evaluated by the inhibition rate, the indexes of thymus and spleen.The growth of tumor was observed by mice models of transplant tumor.RESULTS: The inhibition rate of co-treatment of cisplatin(5.0mg·kg^-1) and cyclophosphamide (7.5 mg·kg^-1) increased 13.6 % -29.6 %, and 33.5 % -34.3 % in comparison with cisplatin and cyclophosphamide, respectively.The inhibition rate in the groups of co-treated was higher than that of in the group of cisplatin and cyclophosphoamide(7.5mg·kg^-1) (P<0.01-0.001).CONCLUSION: Co-treatment of cisplatin in lower dose with cyclophosphamide shows a synergetic anticancer effect in mice models.

Key words: cisplatin, cyclophosphamide, sarcoma 180, toxicity, mice