Abstract: AIM: To investigate the effects of new compounds on angiogenesis of chick chorioallantoic membranes (CAM) targeting on α7 receptor in endothelial cells.METHODS: The blood vessels of CAM were calculated to determine the antiangiogenic effects of 16 new compounds targeting on α7 receptor in endothelium.RESULTS AND CONCULSION: Compared with saline control, compound 13 and 14 between the concentrations 1 and 100 μmol·L^-1 had no effects on angiogenesis.They neither stimulated nor inhibited the angiogenesis.But at the concentration of 1 000 μmol·L^-1, both of them could stimulate angiogenesis significantly.Under the same experimental conditions, compound 5 at the concentrations of 100 and 1 000 μmol·L^-1 could inhibit angiogenesis.But it had no effect on angiogenesis at the concentrations of 1 and 10 μmol·L^-1.

Key words: new compound, endothelial cells, α₇nAChR ;, chick chorioallantoic membranes, angiogenesis