Abstract: AIM: To improve on the acute cumulative death rates method in animal by intravenous (iv) administration.METHODS: A mathematic model was established to simulate the pharmacodynamic and pharmacokinetic process by the program written by Visual Basic.net.This program evaluated the acute cumulative death rates (ACD method) for use of pharmacokinetics of traditional Chinese medicine (TCM).RESULTS: The ACD method related on its first dosage, and an unsuitable dosage could lead to a wrong results.It also had been proved that, by adjusting the 2nd dosage it was a more suitable to wider range of dosage.CONCLUSION: By suitable 2nd dosage and enough animal number, ACD method can be used in the pharmacokinetics of TCM.

Key words: traditional Chinese medicine, pharmacokinetics, acute cumulative death rates, computer simulator