Abstract: AIM: To study the effects of Ginseng fiber on hepatic fibrosis induced by CCl₄ in mice.METHODS: Forty PCR Mice were randomly divided into 4 the control group, the NS group, the colchicine group and the Ginseng fiber groups. Rats in control group were treated by daily oral gavage with vehicle. Rats in other three groups were given SC injection of 40 %CCl₄ 10 ml·kg^-1 and treated by either daily oral gavage with vehicle, or colchicine at 0. 1 ml·kg^-1, or Ginseng fiber at 10 g·kg^-1 for 42 d. The liver injury indexes were measured.RESULTS: Compared with control group, the serum enzymes of alanine aminotransferase (ALT), aspartic acid aminotransferase(AST)were markedly increased but serum albumin (Alb)and A/G were decreased distinctly in CCl₄ group whose liver slides also showed typical liver cirrhosis. Ginseng fiber markedly prevented CCl₄-induced increases in liverweight, serum ALT and TP. Ginseng fiber lightened the hepatic pathological necrosis resulting from CCl₄. The preventive effect of Ginseng fiber was identical to that of colchicine.CONCLUSION: Ginseng fiber can prevent hepatic fibrosis induced by CCl₄ in mice.

Key words: Ginseng fiber, hepatic fibrosis, colchicine, CCl₄, mice