Muscarinic acetylcholine receptors-coupled M channels:a new drug target for neuropsychic diseases

Abstract

Abstract: The M-channel is a voltage-gated potassium channel , distributed in nervous system , playing a key role in controlling neuronal excitability.In brain , the transmitter acetylcholine increases neural activity by inhibiting M-channel via muscarinic acetylcholine receptors.This cholinergic excitation is important for alertness ,arousal , learning and memory.Mutations in M-channel genes result in epilepsy and deafness.M-channel activators are efficacious for treating epilepsy and neuropathic pain;conversely , its inhibitors are useful in improving symptoms of Alzheimer' s disease.Based on recent progress and findings , the M-channel has emerged as a promising drug target for treating neuropsychic diseases.

Key words: muscarinic acetylcholine receptors, Mchannel, KCNQ, neuron, excitability, drug targets

CLC Number:

R338
R964

SONG Ming-ke, HU Guo-yuan, CHEN Hong-zhuan. Muscarinic acetylcholine receptors-coupled M channels:a new drug target for neuropsychic diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(11): 1219-1224.

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