Abstract: AIM: To evaluate the therapeutic effect of treatment with surgery and mifepristone in patients with endometriosis.METHODS: The medical records of 126 endometriosis patients undergoing surgical operation were analyzed retrospectively.There were 28 cases in stage Ⅰ or Ⅱ, 73 cases in stage Ⅲ, and 25 cases in stage Ⅳ. Conservative surgery was performed in 96 cases and semi-conservative surgery in 30 cases.Postoperation, 92 cases continued taking 10 mg·d^-1 of mifepristone for 6 months and 34 cases did not.All patients received 3 to 5 years follow up.RESULTS: The complete remission (CR) rate in mifepristone group was 77.2%, partial remission (PR) rate was22.8%, and recurrence rate was16.3%. The CR of controls was 52.9%, PR was 47.1%, and recurrence rate was 32.4%.There was significant differ-ence between two groups (P<0.05).The side effect of mifepristone occurred in 17.4% of all patients, but it eliminated the remained lesions in 89.1%of all patients. The levels of estradiol, progestin and CA125 in serum from pretreatment or recurrent patients were significantly higher than the patientswith posttreatment of mifepristone (P<0.05).CONCLUSION: Surgery is the principal method for treating endometriosis.Taking mifepristone can improve the prognosis, and decrease the recurrence rate, and maintain the serum markers at normal levels.

Key words: endometriosis, surgery, mifepristone, therapeutic effect