Natural antioxidants-new approaches for suppressing cancer metastasis

Abstract

Abstract: Metastasis is one of the major causes of mortality in cancer patients.The complicated multistep processes of cancer metastasis are involved, refer to gene, extracellular matrix (ECM), motility of cancer cells and angiogenesis.Reactive oxygen species (ROS) is related to each process of metastasis and can promote metastasis of tumour cells.Antioxidant represses the cancer metastasis through scavenging ROS.It is important to develop high performance, non-toxic natural drug from natural antioxidant to inhibit cancer metastasis.The exploration of compounds from polyphenols, flavonoids, terpene, and vitamins may lead to finding new drug for antimetastasis.

Key words: natural antioxidants, reactive oxygen species, cancer, metastasis

CLC Number:

R730.5

YANG Jing-ya, WU Hong-zhong, HU Yi, FENG Jun, LIU Jian-wen. Natural antioxidants-new approaches for suppressing cancer metastasis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(4): 366-370.

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