Advance research of effect of Ligustrazine on cardiovascular system

Abstract

Abstract: Ligustrazine is an active alkaloidal monomer which is extracted from the Chinese traditional herb Chuanxiong (Ligusticum chuanxiong Hort. ). With the in-depth research of Ligustrazine, its clinical use is widen day by day, especially its remarkable efficiency to the Cardiovascular Disease. The chemical structure of Ligustrazine is tetramethyl pyrazine, its four methyl can show different efficiency, when they are replaced by different functional units. It is found that the effect of Ligustrazine in the cardiovascular system has different ways and mechanisms of action. The pharmacological development of Ligustrazine in the cardiovascular system is reviewed.

Key words: Ligustrazine, ischemia-reperfusion injury, myocardial protection

CLC Number:

R285

JIANG Hong, SHI Guang-fei, ZHU Zhu. Advance research of effect of Ligustrazine on cardiovascular system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(5): 484-487.

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