Protection of atorvastatin on cardiac function following ischemia-reperfusion injury in rabbits

Abstract

Abstract: AIM: To observe the effect of atorvastatin (ATV) on myocardial ischemia-reperfusion injury and the role of inducible nitric oxide synthase (iNOS). METHODS: The rabbits were randomly divided into control group, ATV group, ATV+S-Methylisothiourea sulfate (SMT) group, SMT group.All rabbits were subjected to 40 min ischemia and 240 min reperfusion.The hemodynamic variables, CK-MB, LDH-1 and nitric oxide synthase were detected after reperfusion. RESULTS: LVDP and+dp/dt_max decreased by 24.6% and 35.3%respectively following ischemia-reperfusion.Pre-treated by ATV (10 mg·kg^-1·d^-1) for three days, LVDP and+dp/dt_max decreased by 21.7% and 41.3%, CK-MB and LDH-1 by 31.4% and 19.1% and iNOS increased to 102.6%.The reduction of LVDP and+dp/dt_max, CKMB, LDH-1 and iNOS in ATV+SMT group was no statistically significant with those in control group. CONCLUSION: ATV pretreatment protected myocardial ischemia-reperfusion injury by upregulating iNOS.

Key words: atorvastatin, rabbit, myocardium, ischemia-reperfusion, nitric oxide synthase

CLC Number:

R965.2

ZHOU Yi, CHEN Man-hua, LIU Jin-hua, ZHANG Li-yun. Protection of atorvastatin on cardiac function following ischemia-reperfusion injury in rabbits[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(7): 786-789.

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